---
res:
  bibo_abstract:
  - "## Rationale:\r\nDifferentiation trajectories to generate specialized cellular
    features rely on sets of transcription factors (TFs) whose temporal dynamics and
    coexistence underlie morphological and neurochemical divergence among neurons
    and neuroendocrine cells. Even though transcriptional programs were extensively
    studied in the developing nervous system, the coupling of TFs to effector gene
    networks that time and shape the morphogenesis of these polarized cells is less
    known.\r\n\r\n## Results:\r\nHere, we make the curious observation that evolutionarily
    conserved Onecut3, a subordinate in the Onecut TF family known to control fate
    selection in progenitors, is instead expressed in fate-restricted neuroblasts
    in the vertebrate hypothalamus. In particular, a pool of Ascl1-containing progenitors
    in the midgestational mouse hypothalamus gives rise to both GABA and glutamate
    neurons destined to the periventricular and lateral hypothalamus, respectively,
    which uniformly upregulate Onecut3 only when exiting the proliferative zone of
    the 3rd ventricle. By combining single-cell RNA-seq, genetic Onecut3 reporters,
    gain-of-function models in vitro, and loss-of-function analysis in early-developing
    mice and C. elegans, we identify that Onecut3 instructs neuronal differentiation
    and maturation, through a Navigator-2 pathway to modulate neuritogenesis and leading
    process motility.\r\n\r\n\r\n## Conclusion:\r\nOnecut3 executes an unexpected
    function by inducing cytoskeletal modifications of key importance for neuronal
    maturation and network integration during the morphogenesis of many neuronal phenotypes
    in the vertebrate hypothalamus.@eng"
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Maja
      foaf_name: Zupancic, Maja
      foaf_surname: Zupancic
  - foaf_Person:
      foaf_givenName: Erik
      foaf_name: Keimpema, Erik
      foaf_surname: Keimpema
  - foaf_Person:
      foaf_givenName: Evgenii
      foaf_name: Tretiakov, Evgenii
      foaf_surname: Tretiakov
  - foaf_Person:
      foaf_givenName: Pradeep
      foaf_name: Bhandari, Pradeep
      foaf_surname: Bhandari
  - foaf_Person:
      foaf_givenName: Stephanie
      foaf_name: Eder, Stephanie
      foaf_surname: Eder
  - foaf_Person:
      foaf_givenName: Itamar
      foaf_name: Lev, Itamar
      foaf_surname: Lev
  - foaf_Person:
      foaf_givenName: Wolfgang
      foaf_name: Härtig, Wolfgang
      foaf_surname: Härtig
  - foaf_Person:
      foaf_givenName: Manuel
      foaf_name: Zimmer, Manuel
      foaf_surname: Zimmer
  - foaf_Person:
      foaf_givenName: Frederic
      foaf_name: Clotman, Frederic
      foaf_surname: Clotman
  - foaf_Person:
      foaf_givenName: Tibor
      foaf_name: Harkany, Tibor
      foaf_surname: Harkany
  bibo_doi: 10.6084/m9.figshare.22680433
  dct_date: 2023^xs_gYear
  dct_publisher: Repository@
  dct_title: Glutamate and GABA neurons share cascading Onecut3/NAV2-driven differentiation
    trajectories in the developing hypothalamus@
...