article epub_ahead yes Benjamin Tatman author 71cda2f3-e604-11ee-a1df-da10587eda3f Paul Schanda author 7B541462-FAF6-11E9-A490-E8DFE56974250000-0002-9350-7606 PaSc department AlloSpace. The emergence and mechanisms of allostery project Far from being static structures, it is now well accepted that proteins are highly dynamic entities even in the solid state. Here, we review recent progress in application of magic-angle spinning (MAS) NMR for studying the site-specific dynamics of proteins, as assessed using spin-relaxation and measurement of anisotropic spin interactions. We focus on the types of experimental data that are available, and how best to access the information which is provided by these experimental measurements; in particular, we provide a retrospective on the field in light of recent advances in analytical methodologies, which have led to a slow paradigm shift in how we interpret relaxation rate constant measurements made in the solid state. https://creativecommons.org/licenses/by/4.0/ Elsevier2026 eng Solid-state NMRProtein dynamicsMagic-angle spinning 0079-6565 1873-330110.1016/j.pnmrs.2026.101615 156-157 Tatman, Benjamin, and Paul Schanda. “Quantifying Fast Protein Dynamics by Magic-Angle Spinning NMR: Progress in Experimental and Analytical Approaches.” <i>Progress in Nuclear Magnetic Resonance Spectroscopy</i>, vol. 156–157, 101615, Elsevier, 2026, doi:<a href="https://doi.org/10.1016/j.pnmrs.2026.101615">10.1016/j.pnmrs.2026.101615</a>. Tatman B, Schanda P. 2026. Quantifying fast protein dynamics by magic-angle spinning NMR: Progress in experimental and analytical approaches. Progress in Nuclear Magnetic Resonance Spectroscopy. 156–157, 101615. Tatman, B., &#38; Schanda, P. (2026). Quantifying fast protein dynamics by magic-angle spinning NMR: Progress in experimental and analytical approaches. <i>Progress in Nuclear Magnetic Resonance Spectroscopy</i>. Elsevier. <a href="https://doi.org/10.1016/j.pnmrs.2026.101615">https://doi.org/10.1016/j.pnmrs.2026.101615</a> B. Tatman, P. Schanda, Progress in Nuclear Magnetic Resonance Spectroscopy 156–157 (2026). Tatman, Benjamin, and Paul Schanda. “Quantifying Fast Protein Dynamics by Magic-Angle Spinning NMR: Progress in Experimental and Analytical Approaches.” <i>Progress in Nuclear Magnetic Resonance Spectroscopy</i>. Elsevier, 2026. <a href="https://doi.org/10.1016/j.pnmrs.2026.101615">https://doi.org/10.1016/j.pnmrs.2026.101615</a>. Tatman B, Schanda P. Quantifying fast protein dynamics by magic-angle spinning NMR: Progress in experimental and analytical approaches. <i>Progress in Nuclear Magnetic Resonance Spectroscopy</i>. 2026;156-157. doi:<a href="https://doi.org/10.1016/j.pnmrs.2026.101615">10.1016/j.pnmrs.2026.101615</a> B. Tatman and P. Schanda, “Quantifying fast protein dynamics by magic-angle spinning NMR: Progress in experimental and analytical approaches,” <i>Progress in Nuclear Magnetic Resonance Spectroscopy</i>, vol. 156–157. Elsevier, 2026. 229742026-09-22T05:44:22Z2026-10-06T13:00:47Z