Hematologic complications and design challenges in cardiovascular devices

article Hematologic complications and design challenges in cardiovascular devices published yes Damiano Padovani author Nasima S Afsharimani author fe7df522-678a-11eb-9fb9-a37ecf42528e Andrea Cioncolini author Yu Ding author NanoFab department In this review, we provide an engineering assessment of prevalent blood-wetted cardiovascular devices, their hematologic complications, and their interconnections to identify key areas for future research. In fact, the incidence of cardiovascular diseases has promoted the development of various devices to treat these conditions, including mechanical circulatory supports (mechanical pumps that assist or replace failing hearts), artificial valves to replace faulty heart valves, stents to relieve obstructions in blood vessels, vascular grafts to repair/reconstruct damaged vessels, patches to reinforce or reconstruct cardiovascular tissues, and other implants. The hemocompatibility of these cardiovascular devices, namely their ability to interact with blood flow without causing adverse reactions, remains unsatisfactory, and recurrent complications include thrombosis, hemolysis, and bleeding. Therefore, the discussion provided herein will support readers approaching cardiovascular technologies in building a solid foundation and provide everyone with an up-to-date overview of ongoing research in this multidisciplinary field. https://research-explorer.ista.ac.at/download/23088/23108/2026_CommunicationsEngineering_Padovani.pdf application/pdfno Springer Nature2026 eng Communications Engineering 2731-3395 4281651310.1038/s44172-026-00771-9 5 Padovani D, Afsharimani NS, Cioncolini A, Ding Y. 2026. Hematologic complications and design challenges in cardiovascular devices. Communications Engineering. 5, 167. D. Padovani, N. S. Afsharimani, A. Cioncolini, and Y. Ding, “Hematologic complications and design challenges in cardiovascular devices,” Communications Engineering, vol. 5. Springer Nature, 2026. D. Padovani, N.S. Afsharimani, A. Cioncolini, Y. Ding, Communications Engineering 5 (2026). Padovani D, Afsharimani NS, Cioncolini A, Ding Y. Hematologic complications and design challenges in cardiovascular devices. Communications Engineering. 2026;5. doi:<a href="https://doi.org/10.1038/s44172-026-00771-9">10.1038/s44172-026-00771-9</a> Padovani, Damiano, et al. “Hematologic Complications and Design Challenges in Cardiovascular Devices.” Communications Engineering, vol. 5, 167, Springer Nature, 2026, doi:<a href="https://doi.org/10.1038/s44172-026-00771-9">10.1038/s44172-026-00771-9</a>. Padovani, D., Afsharimani, N. S., Cioncolini, A., & Ding, Y. (2026). Hematologic complications and design challenges in cardiovascular devices. Communications Engineering. Springer Nature. <a href="https://doi.org/10.1038/s44172-026-00771-9">https://doi.org/10.1038/s44172-026-00771-9</a> Padovani, Damiano, Nasima S Afsharimani, Andrea Cioncolini, and Yu Ding. “Hematologic Complications and Design Challenges in Cardiovascular Devices.” Communications Engineering. Springer Nature, 2026. <a href="https://doi.org/10.1038/s44172-026-00771-9">https://doi.org/10.1038/s44172-026-00771-9</a>. 230882026-10-11T22:02:04Z2026-10-12T11:34:48Z