---
_id: '2309'
abstract:
- lang: eng
  text: The importance of chloride ions in cell physiology has not been fully recognized
    until recently, in spite of the fact that chloride (Cl-), together with bicarbonate,
    is the most abundant free anion in animal cells, and performs or determines fundamental
    biological functions in all tissues. For many years it was thought that Cl- was
    distributed in thermodynamic equilibrium across the plasma membrane of most cells.
    Research carried out during the last couple of decades has led to a dramatic change
    in this simplistic view. We now know that most animal cells, neurons included,
    exhibit a non-equilibrium distribution of Cl- across their plasma membranes. Over
    the last 10 to 15 years, with the growth of molecular biology and the advent of
    new optical methods, an enormous amount of exciting new information has become
    available on the molecular structure and function of Cl- channels and carriers.
    In nerve cells, Cl- channels and carriers play key functional roles in GABA- and
    glycine-mediated synaptic inhibition, neuronal growth and development, extracellular
    potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume
    control. Disruption of Cl- homeostasis in neurons underlies pathological conditions
    such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic
    inflammation. This book is about how chloride ions are regulated and how they
    cross the plasma membrane of neurons. It spans from molecular structure and function
    of carriers and channels involved in Cl- transport to their role in various diseases.
    * The first comprehensive book on the structure, molecular biology, cell physiology,
    and role in diseases of chloride transporters / channels in the nervous system
    in almost 20 years * Chloride is the most abundant free anion in animal cells.
    THis book summarizes and integrates for the first time the important research
    of the past two decades that has shown that Cl- channels and carriers play key
    functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth
    and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter
    uptake and cell volume control. * The first book that systematically discusses
    the result of disruption of Cl- homeostasis in neurons which underlies pathological
    conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain
    and neurogenic inflammation. * Spanning topics from molecular structure and function
    of carriers and channels involved in Cl- transport to their role in various diseases.
    * Involves all of the leading researchers in the field. * INcludes an extensive
    introductory section that covers basic thermodynamic and kinetics aspects of Cl-
    transport, as well as current methods for studying Cl- regulation, spanning from
    fluorescent dyes in single cells to knock-out models to make the book available
    for a growing population of graduate students and postdocs entering the field.
author:
- first_name: Tobias
  full_name: Stauber, Tobias
  last_name: Stauber
- first_name: Gaia
  full_name: Gaia Novarino
  id: 3E57A680-F248-11E8-B48F-1D18A9856A87
  last_name: Novarino
  orcid: 0000-0002-7673-7178
- first_name: Thomas
  full_name: Jentsch, Thomas J
  last_name: Jentsch
citation:
  ama: 'Stauber T, Novarino G, Jentsch T. The CLC family of chloride channels and
    transporters. In: <i>Physiology and Pathology of Chloride Transporters and Channels
    in the Nervous System</i>. Elsevier; 2010:209-231. doi:<a href="https://doi.org/10.1016/B978-0-12-374373-2.00012-1">10.1016/B978-0-12-374373-2.00012-1</a>'
  apa: Stauber, T., Novarino, G., &#38; Jentsch, T. (2010). The CLC family of chloride
    channels and transporters. In <i>Physiology and Pathology of chloride transporters
    and channels in the nervous system</i> (pp. 209–231). Elsevier. <a href="https://doi.org/10.1016/B978-0-12-374373-2.00012-1">https://doi.org/10.1016/B978-0-12-374373-2.00012-1</a>
  chicago: Stauber, Tobias, Gaia Novarino, and Thomas Jentsch. “The CLC Family of
    Chloride Channels and Transporters.” In <i>Physiology and Pathology of Chloride
    Transporters and Channels in the Nervous System</i>, 209–31. Elsevier, 2010. <a
    href="https://doi.org/10.1016/B978-0-12-374373-2.00012-1">https://doi.org/10.1016/B978-0-12-374373-2.00012-1</a>.
  ieee: T. Stauber, G. Novarino, and T. Jentsch, “The CLC family of chloride channels
    and transporters,” in <i>Physiology and Pathology of chloride transporters and
    channels in the nervous system</i>, Elsevier, 2010, pp. 209–231.
  ista: 'Stauber T, Novarino G, Jentsch T. 2010.The CLC family of chloride channels
    and transporters. In: Physiology and Pathology of chloride transporters and channels
    in the nervous system. , 209–231.'
  mla: Stauber, Tobias, et al. “The CLC Family of Chloride Channels and Transporters.”
    <i>Physiology and Pathology of Chloride Transporters and Channels in the Nervous
    System</i>, Elsevier, 2010, pp. 209–31, doi:<a href="https://doi.org/10.1016/B978-0-12-374373-2.00012-1">10.1016/B978-0-12-374373-2.00012-1</a>.
  short: T. Stauber, G. Novarino, T. Jentsch, in:, Physiology and Pathology of Chloride
    Transporters and Channels in the Nervous System, Elsevier, 2010, pp. 209–231.
date_created: 2018-12-11T11:56:54Z
date_published: 2010-01-01T00:00:00Z
date_updated: 2021-01-12T06:56:41Z
day: '01'
doi: 10.1016/B978-0-12-374373-2.00012-1
extern: 1
month: '01'
page: 209 - 231
publication: Physiology and Pathology of chloride transporters and channels in the
  nervous system
publication_status: published
publisher: Elsevier
publist_id: '4616'
quality_controlled: 0
status: public
title: The CLC family of chloride channels and transporters
type: book_chapter
year: '2010'
...