---
res:
  bibo_abstract:
  - 'Homologous recombination is ubiquitous across evolution, generating variation
    through genetic reshuffling. Although bacteria lack meiotic recombination, homologous
    recombination has been known to extensively shape their genomes. However, the
    mechanisms and ecological conditions sustaining frequent recombination in bacteria
    remain unclear. Using an Escherichia coli–P1 phage model system, we reveal how
    frequent recombination emerges from CRISPR-based herd immunity to a generalized
    transducing phage (DNA vector). Herd immunity maintains phage-susceptible donor
    bacteria, recipient immune bacteria, and transducing phage, which promotes chromosomal
    gene flow that exceeds spontaneous mutation by up to two orders of magnitude.
    Notably, recombination begins as bacterial cultures enter stationary phase, when
    canonical mutation supply through population growth and DNA replication is strongly
    reduced, and recombination can be reinitiated by brief fresh nutrient pulses.
    Genetic analysis showed that stationary-phase recombination requires recA, recB,
    and recG, connecting this process to a defined homologous recombination pathway,
    and suggests a plausible transcriptional regulatory link to transition to nutrient
    limitation. Bacterial herd immunity therefore has an unexpected evolutionary consequence:
    it can promote homologous recombination by turning phages into de facto pollinators.
    This mechanism can help explain how high rates of homologous recombination may
    be sustained across bacterial populations and suggests that bacterial immune systems
    can shape molecular evolution not only by blocking infection but also by regulating
    genetic exchange.@eng'
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Pavel
      foaf_name: Payne, Pavel
      foaf_surname: Payne
      foaf_workInfoHomepage: http://www.librecat.org/personId=35F78294-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-2711-9453
  - foaf_Person:
      foaf_givenName: Pavel
      foaf_name: Plevka, Pavel
      foaf_surname: Plevka
  - foaf_Person:
      foaf_givenName: Jonathan P
      foaf_name: Bollback, Jonathan P
      foaf_surname: Bollback
      foaf_workInfoHomepage: http://www.librecat.org/personId=2C6FA9CC-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-4624-4612
  - foaf_Person:
      foaf_givenName: Calin C
      foaf_name: Guet, Calin C
      foaf_surname: Guet
      foaf_workInfoHomepage: http://www.librecat.org/personId=47F8433E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-6220-2052
  bibo_doi: 10.1093/molbev/msag238
  bibo_issue: '10'
  bibo_volume: 43
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0737-4038
  - http://id.crossref.org/issn/1537-1719
  dct_language: eng
  dct_publisher: Oxford University Press@
  dct_subject:
  - homologous recombination
  - defense systems
  - CRISPR-Cas
  - herd immunity
  - stationary phase
  - bacterial evolution
  dct_title: Herd immunity underlies homologous recombination in stationary phase
    bacteria@
  fabio_hasPubmedId: '42827080'
...