---
res:
  bibo_abstract:
  - Presenilin-1 (PS1) is an endoplasmic reticulum protein, most known for its role
    in pathogenesis of familial Alzheimer’s Disease (AD). PS1 has been attributed
    roles in intracellular calcium homeostasis in the brain, as well as in the pancreatic
    beta cells, where it has been shown to be fundamental for the initial phase of
    glucose-induced insulin secretion. To gain mechanistic insight into beta cell
    autonomous function of PS1, we have examined various beta cell models and found
    that PS1 controls glycolytic flux of pancreatic beta cells by regulating sub-mitochondrial
    Ca2+ homeostasis. Transient knock down of PS1 yielded a glycolytic bottleneck
    at the step catalyzed by glyceraldehyde-3-phosphate dehydrogenase, resulting in
    defective glucose responsiveness. Moreover, we show that PS1 is needed for the
    preservation of beta cell identity, likely due to its role in glycolysis. Finally,
    we show that mouse islets from an in vivo model of AD mimic the defective glucose
    responsiveness seen in beta cells with transient PS1 knock down, while the identity
    loss and whole-body glucose homeostasis are not severely impacted, suggesting
    an adaptive response. Thus, the current work highlights beta cell autonomous role
    of PS1 and adds a layer of complexity in its impact on whole body metabolism.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Zhanat
      foaf_name: Koshenov, Zhanat
      foaf_surname: Koshenov
  - foaf_Person:
      foaf_givenName: Sandra
      foaf_name: Postic, Sandra
      foaf_surname: Postic
  - foaf_Person:
      foaf_givenName: Gabriela
      foaf_name: Schoiswohl, Gabriela
      foaf_surname: Schoiswohl
  - foaf_Person:
      foaf_givenName: Savina
      foaf_name: Van Amsterdam, Savina
      foaf_surname: Van Amsterdam
  - foaf_Person:
      foaf_givenName: Victoria
      foaf_name: Hois-Zelinka, Victoria
      foaf_surname: Hois-Zelinka
  - foaf_Person:
      foaf_givenName: Furkan E.
      foaf_name: Oflaz, Furkan E.
      foaf_surname: Oflaz
  - foaf_Person:
      foaf_givenName: Rene
      foaf_name: Rost, Rene
      foaf_surname: Rost
  - foaf_Person:
      foaf_givenName: Oleksandra
      foaf_name: Tiapko, Oleksandra
      foaf_surname: Tiapko
  - foaf_Person:
      foaf_givenName: Benjamin
      foaf_name: Gottschalk, Benjamin
      foaf_surname: Gottschalk
  - foaf_Person:
      foaf_givenName: Martin
      foaf_name: Hirtl, Martin
      foaf_surname: Hirtl
  - foaf_Person:
      foaf_givenName: Olaf G.
      foaf_name: Bachkoenig, Olaf G.
      foaf_surname: Bachkoenig
  - foaf_Person:
      foaf_givenName: Aigerim
      foaf_name: Koshenova, Aigerim
      foaf_surname: Koshenova
  - foaf_Person:
      foaf_givenName: Yusuf C.
      foaf_name: Erdogan, Yusuf C.
      foaf_surname: Erdogan
  - foaf_Person:
      foaf_givenName: Adlet
      foaf_name: Sagintayev, Adlet
      foaf_surname: Sagintayev
  - foaf_Person:
      foaf_givenName: Anita
      foaf_name: Krnjic, Anita
      foaf_surname: Krnjic
  - foaf_Person:
      foaf_givenName: Johannes U.
      foaf_name: Pfabe, Johannes U.
      foaf_surname: Pfabe
  - foaf_Person:
      foaf_givenName: Srdjan
      foaf_name: Sarikas, Srdjan
      foaf_surname: Sarikas
      foaf_workInfoHomepage: http://www.librecat.org/personId=35F0286E-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Bernhard
      foaf_name: Hochreiter, Bernhard
      foaf_surname: Hochreiter
      foaf_workInfoHomepage: http://www.librecat.org/personId=e6cab3de-17f6-11ed-9210-c1e42e045e9d
  - foaf_Person:
      foaf_givenName: Juergen
      foaf_name: Gindlhuber, Juergen
      foaf_surname: Gindlhuber
  - foaf_Person:
      foaf_givenName: Matthias
      foaf_name: Schittmayer, Matthias
      foaf_surname: Schittmayer
  - foaf_Person:
      foaf_givenName: Jelena
      foaf_name: Tadic, Jelena
      foaf_surname: Tadic
  - foaf_Person:
      foaf_givenName: Barbara
      foaf_name: Ehall, Barbara
      foaf_surname: Ehall
  - foaf_Person:
      foaf_givenName: Frank
      foaf_name: Madeo, Frank
      foaf_surname: Madeo
  - foaf_Person:
      foaf_givenName: Tobias
      foaf_name: Madl, Tobias
      foaf_surname: Madl
  - foaf_Person:
      foaf_givenName: Roland
      foaf_name: Malli, Roland
      foaf_surname: Malli
  - foaf_Person:
      foaf_givenName: Ruth
      foaf_name: Birner-Gruenberger, Ruth
      foaf_surname: Birner-Gruenberger
  - foaf_Person:
      foaf_givenName: Thomas
      foaf_name: Pieber, Thomas
      foaf_surname: Pieber
  - foaf_Person:
      foaf_givenName: Tobias
      foaf_name: Eisenberg, Tobias
      foaf_surname: Eisenberg
  - foaf_Person:
      foaf_givenName: Marjan
      foaf_name: Slak Rupnik, Marjan
      foaf_surname: Slak Rupnik
  - foaf_Person:
      foaf_givenName: Wolfgang F.
      foaf_name: Graier, Wolfgang F.
      foaf_surname: Graier
  bibo_doi: 10.1038/s42003-026-10581-6
  bibo_volume: 9
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/2399-3642
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_title: Presenilin-1 controls glycolysis and identity of pancreatic beta cells@
  fabio_hasPubmedId: '42387039'
...