{"article_number":"1315","researchdata_availability":"upon request","doi":"10.1038/s42003-026-10581-6","file":[{"file_id":"23161","file_size":1819866,"content_type":"application/pdf","date_updated":"2026-10-19T06:19:39Z","file_name":"2026_CommunicationsBiology_Koshenov.pdf","checksum":"b90e60a625fcac8ef5d9ff968792d675","date_created":"2026-10-19T06:19:39Z","success":1,"creator":"dernst","relation":"main_file","access_level":"open_access"}],"volume":9,"oa":1,"day":"08","dataavailabilitystatement":"The data supporting the findings of this research can be obtained from the authors upon a reasonable request; please refer to the author’s contributions for details regarding specific datasets. Numerical source data underlying graphs in this article can be found in Supplementary data file. Supplementary Figs. and figure legends are included in the Supplementary file. The code used in this study is available from the authors on reasonable request.","publisher":"Springer Nature","department":[{"_id":"FISS"}],"month":"10","external_id":{"pmid":["42387039"]},"article_processing_charge":"Yes","has_accepted_license":"1","date_published":"2026-10-08T00:00:00Z","file_date_updated":"2026-10-19T06:19:39Z","das_tickbox":"1","fulldoi":"https://doi.org/10.1038/s42003-026-10581-6","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"ddc":["570"],"intvolume":"         9","publication_status":"published","year":"2026","quality_controlled":"1","pmid":1,"OA_type":"gold","OA_place":"publisher","language":[{"iso":"eng"}],"scopus_import":"1","publication":"Communications Biology","acknowledgement":"We appreciate the technical assistance from Anna Schreilechner. We are grateful for support by all members of the animal facility team at IMB, University of Graz, as well as K. Zierler for assistance with animal licenses.  F.M, T.E., T.M., T.P., and W.F.G. are grateful to the Austrian Science Fund (FWF) for the excellence cluster 10.55776/COE14 (MetAGE), which was additionally supported by Land Styria, Stadt Graz, University of Graz and Medical University of Graz. This research was further supported by the FWF via the DKplus program 10.55776/W1226 (DK-MCD) to F.M., T.M., R.B.G., and W.F.G., 10.55776/P28529, 10.55776/I3716 (to R.M.), 10.55776/P28854, 10.55776/I3792, 10.55776/DOC130 (to T.M.), and 10.55776/I4319 (to. M.S.R.); the Austrian Research Promotion Agency (FFG) grants 864690 and 870454; the Integrative Metabolism Research Center Graz; the Austrian Infrastructure Program 2016/2017 (to T.M.), and 10.55776/COE7, 10.55776/COE17, 10.55776/FG12 and 10.55776/F73 (to R.B.G.); the Styrian Government; the City of Graz; and BioTechMed-Graz (flagship project) (to T.M.); the MEFO Graz (to W.F.G.). F.E.O., J.G. and Z.K. were doctoral fellows in the doctoral program Metabolic and Cardiovascular Disease (MCD) (FWF, 10.55776/W 1226) at the Medical University of Graz. S.v.A. and A.S. are thesis students in the excellence cluster 10.55776/COE14 (MetAGE, W.F.G.). M.H. was a fellow of the Molecular Medicine (MolMed) doctoral program at the Medical University of Graz supported by MEFO Graz. The SIM equipment is part of the Nikon Center of Excellence, Graz, and is supported by the Austrian infrastructure program 2013/ 2014, Nikon Austria Inc., and BioTechMed (to W.F.G.). Our thanks go to Shimadzu Austria for supporting this research through instrument access given in the Metabolomics and Bioprocess Analytics laboratory (TU Wien) (R.B.G.). For open access purposes, the authors have applied a CC BY public copyright license to any author-accepted manuscript version arising from this submission.” We thank the Medical University of Graz for financial support.","publication_identifier":{"eissn":["2399-3642"]},"citation":{"ama":"Koshenov Z, Postic S, Schoiswohl G, et al. Presenilin-1 controls glycolysis and identity of pancreatic beta cells. <i>Communications Biology</i>. 2026;9. doi:<a href=\"https://doi.org/10.1038/s42003-026-10581-6\">10.1038/s42003-026-10581-6</a>","mla":"Koshenov, Zhanat, et al. “Presenilin-1 Controls Glycolysis and Identity of Pancreatic Beta Cells.” <i>Communications Biology</i>, vol. 9, 1315, Springer Nature, 2026, doi:<a href=\"https://doi.org/10.1038/s42003-026-10581-6\">10.1038/s42003-026-10581-6</a>.","short":"Z. Koshenov, S. Postic, G. Schoiswohl, S. Van Amsterdam, V. Hois-Zelinka, F.E. Oflaz, R. Rost, O. Tiapko, B. Gottschalk, M. Hirtl, O.G. Bachkoenig, A. Koshenova, Y.C. Erdogan, A. Sagintayev, A. Krnjic, J.U. Pfabe, S. Sarikas, B. Hochreiter, J. Gindlhuber, M. Schittmayer, J. Tadic, B. Ehall, F. Madeo, T. Madl, R. Malli, R. Birner-Gruenberger, T. Pieber, T. Eisenberg, M. Slak Rupnik, W.F. Graier, Communications Biology 9 (2026).","ista":"Koshenov Z, Postic S, Schoiswohl G, Van Amsterdam S, Hois-Zelinka V, Oflaz FE, Rost R, Tiapko O, Gottschalk B, Hirtl M, Bachkoenig OG, Koshenova A, Erdogan YC, Sagintayev A, Krnjic A, Pfabe JU, Sarikas S, Hochreiter B, Gindlhuber J, Schittmayer M, Tadic J, Ehall B, Madeo F, Madl T, Malli R, Birner-Gruenberger R, Pieber T, Eisenberg T, Slak Rupnik M, Graier WF. 2026. Presenilin-1 controls glycolysis and identity of pancreatic beta cells. Communications Biology. 9, 1315.","ieee":"Z. Koshenov <i>et al.</i>, “Presenilin-1 controls glycolysis and identity of pancreatic beta cells,” <i>Communications Biology</i>, vol. 9. Springer Nature, 2026.","chicago":"Koshenov, Zhanat, Sandra Postic, Gabriela Schoiswohl, Savina Van Amsterdam, Victoria Hois-Zelinka, Furkan E. Oflaz, Rene Rost, et al. “Presenilin-1 Controls Glycolysis and Identity of Pancreatic Beta Cells.” <i>Communications Biology</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1038/s42003-026-10581-6\">https://doi.org/10.1038/s42003-026-10581-6</a>.","apa":"Koshenov, Z., Postic, S., Schoiswohl, G., Van Amsterdam, S., Hois-Zelinka, V., Oflaz, F. E., … Graier, W. F. (2026). Presenilin-1 controls glycolysis and identity of pancreatic beta cells. <i>Communications Biology</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s42003-026-10581-6\">https://doi.org/10.1038/s42003-026-10581-6</a>"},"DOAJ_listed":"1","license":"https://creativecommons.org/licenses/by/4.0/","PlanS_conform":"1","date_updated":"2026-10-19T06:23:26Z","supplementarymaterial":"yes","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"full_name":"Koshenov, Zhanat","first_name":"Zhanat","last_name":"Koshenov"},{"full_name":"Postic, Sandra","last_name":"Postic","first_name":"Sandra"},{"first_name":"Gabriela","last_name":"Schoiswohl","full_name":"Schoiswohl, Gabriela"},{"full_name":"Van Amsterdam, Savina","last_name":"Van Amsterdam","first_name":"Savina"},{"full_name":"Hois-Zelinka, Victoria","last_name":"Hois-Zelinka","first_name":"Victoria"},{"full_name":"Oflaz, Furkan E.","last_name":"Oflaz","first_name":"Furkan E."},{"last_name":"Rost","first_name":"Rene","full_name":"Rost, Rene"},{"first_name":"Oleksandra","last_name":"Tiapko","full_name":"Tiapko, Oleksandra"},{"last_name":"Gottschalk","first_name":"Benjamin","full_name":"Gottschalk, Benjamin"},{"first_name":"Martin","last_name":"Hirtl","full_name":"Hirtl, Martin"},{"full_name":"Bachkoenig, Olaf G.","last_name":"Bachkoenig","first_name":"Olaf G."},{"full_name":"Koshenova, Aigerim","first_name":"Aigerim","last_name":"Koshenova"},{"last_name":"Erdogan","first_name":"Yusuf C.","full_name":"Erdogan, Yusuf C."},{"full_name":"Sagintayev, Adlet","last_name":"Sagintayev","first_name":"Adlet"},{"full_name":"Krnjic, Anita","last_name":"Krnjic","first_name":"Anita"},{"full_name":"Pfabe, Johannes U.","first_name":"Johannes U.","last_name":"Pfabe"},{"full_name":"Sarikas, Srdjan","last_name":"Sarikas","first_name":"Srdjan","id":"35F0286E-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Hochreiter, Bernhard","first_name":"Bernhard","last_name":"Hochreiter","id":"e6cab3de-17f6-11ed-9210-c1e42e045e9d"},{"full_name":"Gindlhuber, Juergen","last_name":"Gindlhuber","first_name":"Juergen"},{"full_name":"Schittmayer, Matthias","last_name":"Schittmayer","first_name":"Matthias"},{"full_name":"Tadic, Jelena","first_name":"Jelena","last_name":"Tadic"},{"first_name":"Barbara","last_name":"Ehall","full_name":"Ehall, Barbara"},{"last_name":"Madeo","first_name":"Frank","full_name":"Madeo, Frank"},{"first_name":"Tobias","last_name":"Madl","full_name":"Madl, Tobias"},{"first_name":"Roland","last_name":"Malli","full_name":"Malli, Roland"},{"full_name":"Birner-Gruenberger, Ruth","first_name":"Ruth","last_name":"Birner-Gruenberger"},{"full_name":"Pieber, Thomas","last_name":"Pieber","first_name":"Thomas"},{"last_name":"Eisenberg","first_name":"Tobias","full_name":"Eisenberg, Tobias"},{"last_name":"Slak Rupnik","first_name":"Marjan","full_name":"Slak Rupnik, Marjan"},{"full_name":"Graier, Wolfgang F.","last_name":"Graier","first_name":"Wolfgang F."}],"date_created":"2026-10-18T22:01:50Z","status":"public","title":"Presenilin-1 controls glycolysis and identity of pancreatic beta cells","_id":"23148","abstract":[{"text":"Presenilin-1 (PS1) is an endoplasmic reticulum protein, most known for its role in pathogenesis of familial Alzheimer’s Disease (AD). PS1 has been attributed roles in intracellular calcium homeostasis in the brain, as well as in the pancreatic beta cells, where it has been shown to be fundamental for the initial phase of glucose-induced insulin secretion. To gain mechanistic insight into beta cell autonomous function of PS1, we have examined various beta cell models and found that PS1 controls glycolytic flux of pancreatic beta cells by regulating sub-mitochondrial Ca2+ homeostasis. Transient knock down of PS1 yielded a glycolytic bottleneck at the step catalyzed by glyceraldehyde-3-phosphate dehydrogenase, resulting in defective glucose responsiveness. Moreover, we show that PS1 is needed for the preservation of beta cell identity, likely due to its role in glycolysis. Finally, we show that mouse islets from an in vivo model of AD mimic the defective glucose responsiveness seen in beta cells with transient PS1 knock down, while the identity loss and whole-body glucose homeostasis are not severely impacted, suggesting an adaptive response. Thus, the current work highlights beta cell autonomous role of PS1 and adds a layer of complexity in its impact on whole body metabolism.","lang":"eng"}],"oa_version":"Published Version","type":"journal_article","article_type":"original"}