---
OA_place: repository
OA_type: green
_id: '23180'
abstract:
- lang: eng
  text: Defense against pathogens and parasites requires substantial investment of
    energy and resources on part of the host. This makes the host immune function
    dependent on availability and accessibility of resources. A resource deprived
    host is therefore expected to be more susceptible to infections, although empirical
    results do not always align with this prediction. Limiting host access to resources
    can additionally impact within-host pathogen numbers, either directly by altering
    the amount of resources available to the pathogens for proliferation or indirectly
    by altering the efficiency of the host immune system. We tested for the effects
    of host starvation (complete deprivation of resources) on susceptibility to bacterial
    pathogens, and within-host pathogen proliferation, in Drosophila melanogaster
    females. Our results show that starvation increases post-infection mortality of
    the host, but in a pathogen-specific manner. This increase in mortality is always
    accompanied by increased within-host pathogen proliferation. We therefore propose
    that starvation compromises host resistance to bacterial infections in Drosophila
    melanogaster females thereby increasing susceptibility to infections.
article_processing_charge: No
author:
- first_name: Aabeer
  full_name: Basu, Aabeer
  last_name: Basu
- first_name: Aparajita
  full_name: Singh, Aparajita
  last_name: Singh
- first_name: Suhaas
  full_name: Sehgal, Suhaas
  last_name: Sehgal
- first_name: Tanvi
  full_name: Madaan, Tanvi
  last_name: Madaan
- first_name: Nagaraj Guru
  full_name: Prasad, Nagaraj Guru
  last_name: Prasad
citation:
  ama: Basu A, Singh A, Sehgal S, Madaan T, Prasad NG. Starvation increases susceptibility
    to bacterial infection and promotes systemic pathogen proliferation in Drosophila
    melanogaster females. 2022. doi:<a href="https://doi.org/10.5061/dryad.pvmcvdnp8">10.5061/dryad.pvmcvdnp8</a>
  apa: Basu, A., Singh, A., Sehgal, S., Madaan, T., &#38; Prasad, N. G. (2022). Starvation
    increases susceptibility to bacterial infection and promotes systemic pathogen
    proliferation in Drosophila melanogaster females. Dryad. <a href="https://doi.org/10.5061/dryad.pvmcvdnp8">https://doi.org/10.5061/dryad.pvmcvdnp8</a>
  chicago: Basu, Aabeer, Aparajita Singh, Suhaas Sehgal, Tanvi Madaan, and Nagaraj
    Guru Prasad. “Starvation Increases Susceptibility to Bacterial Infection and Promotes
    Systemic Pathogen Proliferation in Drosophila Melanogaster Females.” Dryad, 2022.
    <a href="https://doi.org/10.5061/dryad.pvmcvdnp8">https://doi.org/10.5061/dryad.pvmcvdnp8</a>.
  ieee: A. Basu, A. Singh, S. Sehgal, T. Madaan, and N. G. Prasad, “Starvation increases
    susceptibility to bacterial infection and promotes systemic pathogen proliferation
    in Drosophila melanogaster females.” Dryad, 2022.
  ista: Basu A, Singh A, Sehgal S, Madaan T, Prasad NG. 2022. Starvation increases
    susceptibility to bacterial infection and promotes systemic pathogen proliferation
    in Drosophila melanogaster females, Dryad, <a href="https://doi.org/10.5061/dryad.pvmcvdnp8">10.5061/dryad.pvmcvdnp8</a>.
  mla: Basu, Aabeer, et al. <i>Starvation Increases Susceptibility to Bacterial Infection
    and Promotes Systemic Pathogen Proliferation in Drosophila Melanogaster Females</i>.
    Dryad, 2022, doi:<a href="https://doi.org/10.5061/dryad.pvmcvdnp8">10.5061/dryad.pvmcvdnp8</a>.
  short: A. Basu, A. Singh, S. Sehgal, T. Madaan, N.G. Prasad, (2022).
date_created: 2026-10-21T10:42:59Z
date_published: 2022-05-17T00:00:00Z
date_updated: 2026-10-21T10:43:22Z
day: '17'
department:
- _id: SyCr
doi: 10.5061/dryad.pvmcvdnp8
fulldoi: https://doi.org/10.5061/dryad.pvmcvdnp8
main_file_link:
- open_access: '1'
  url: https://doi.org/10.5061/dryad.pvmcvdnp8
month: '05'
oa: 1
oa_version: None
publisher: Dryad
related_material:
  record:
  - id: '18171'
    relation: used_in_publication
    status: public
status: public
title: Starvation increases susceptibility to bacterial infection and promotes systemic
  pathogen proliferation in Drosophila melanogaster females
type: research_data_reference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
year: '2022'
...