---
_id: '2472'
abstract:
- lang: eng
  text: Plant-specific PIN-formed (PIN) efflux transporters for the plant hormone
    auxin are required for tissue-specific directional auxin transport and cellular
    auxin homeostasis. The Arabidopsis PIN protein family has been shown to play important
    roles in developmental processes such as embryogenesis, organogenesis, vascular
    tissue differentiation, root meristem patterning and tropic growth. Here we analyzed
    roles of the less characterised Arabidopsis PIN6 auxin transporter. PIN6 is auxin-inducible
    and is expressed during multiple auxin-regulated developmental processes. Loss
    of pin6 function interfered with primary root growth and lateral root development.
    Misexpression of PIN6 affected auxin transport and interfered with auxin homeostasis
    in other growth processes such as shoot apical dominance, lateral root primordia
    development, adventitious root formation, root hair outgrowth and root waving.
    These changes in auxin-regulated growth correlated with a reduction in total auxin
    transport as well as with an altered activity of DR5-GUS auxin response reporter.
    Overall, the data indicate that PIN6 regulates auxin homeostasis during plant
    development.
article_number: e70069
article_processing_charge: No
author:
- first_name: Christopher
  full_name: Cazzonelli, Christopher
  last_name: Cazzonelli
- first_name: Marleen
  full_name: Vanstraelen, Marleen
  last_name: Vanstraelen
- first_name: Sibu
  full_name: Simon, Sibu
  id: 4542EF9A-F248-11E8-B48F-1D18A9856A87
  last_name: Simon
  orcid: 0000-0002-1998-6741
- first_name: Kuide
  full_name: Yin, Kuide
  last_name: Yin
- first_name: Ashley
  full_name: Carron Arthur, Ashley
  last_name: Carron Arthur
- first_name: Nazia
  full_name: Nisar, Nazia
  last_name: Nisar
- first_name: Gauri
  full_name: Tarle, Gauri
  last_name: Tarle
- first_name: Abby
  full_name: Cuttriss, Abby
  last_name: Cuttriss
- first_name: Iain
  full_name: Searle, Iain
  last_name: Searle
- first_name: Eva
  full_name: Benková, Eva
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
- first_name: Ulrike
  full_name: Mathesius, Ulrike
  last_name: Mathesius
- first_name: Josette
  full_name: Masle, Josette
  last_name: Masle
- first_name: Jirí
  full_name: Friml, Jirí
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
- first_name: Barry
  full_name: Pogson, Barry
  last_name: Pogson
citation:
  ama: Cazzonelli C, Vanstraelen M, Simon S, et al. Role of the Arabidopsis PIN6 auxin
    transporter in auxin homeostasis and auxin-mediated development. <i>PLoS One</i>.
    2013;8(7). doi:<a href="https://doi.org/10.1371/journal.pone.0070069">10.1371/journal.pone.0070069</a>
  apa: Cazzonelli, C., Vanstraelen, M., Simon, S., Yin, K., Carron Arthur, A., Nisar,
    N., … Pogson, B. (2013). Role of the Arabidopsis PIN6 auxin transporter in auxin
    homeostasis and auxin-mediated development. <i>PLoS One</i>. Public Library of
    Science. <a href="https://doi.org/10.1371/journal.pone.0070069">https://doi.org/10.1371/journal.pone.0070069</a>
  chicago: Cazzonelli, Christopher, Marleen Vanstraelen, Sibu Simon, Kuide Yin, Ashley
    Carron Arthur, Nazia Nisar, Gauri Tarle, et al. “Role of the Arabidopsis PIN6
    Auxin Transporter in Auxin Homeostasis and Auxin-Mediated Development.” <i>PLoS
    One</i>. Public Library of Science, 2013. <a href="https://doi.org/10.1371/journal.pone.0070069">https://doi.org/10.1371/journal.pone.0070069</a>.
  ieee: C. Cazzonelli <i>et al.</i>, “Role of the Arabidopsis PIN6 auxin transporter
    in auxin homeostasis and auxin-mediated development,” <i>PLoS One</i>, vol. 8,
    no. 7. Public Library of Science, 2013.
  ista: Cazzonelli C, Vanstraelen M, Simon S, Yin K, Carron Arthur A, Nisar N, Tarle
    G, Cuttriss A, Searle I, Benková E, Mathesius U, Masle J, Friml J, Pogson B. 2013.
    Role of the Arabidopsis PIN6 auxin transporter in auxin homeostasis and auxin-mediated
    development. PLoS One. 8(7), e70069.
  mla: Cazzonelli, Christopher, et al. “Role of the Arabidopsis PIN6 Auxin Transporter
    in Auxin Homeostasis and Auxin-Mediated Development.” <i>PLoS One</i>, vol. 8,
    no. 7, e70069, Public Library of Science, 2013, doi:<a href="https://doi.org/10.1371/journal.pone.0070069">10.1371/journal.pone.0070069</a>.
  short: C. Cazzonelli, M. Vanstraelen, S. Simon, K. Yin, A. Carron Arthur, N. Nisar,
    G. Tarle, A. Cuttriss, I. Searle, E. Benková, U. Mathesius, J. Masle, J. Friml,
    B. Pogson, PLoS One 8 (2013).
date_created: 2018-12-11T11:57:52Z
date_published: 2013-07-29T00:00:00Z
date_updated: 2025-09-29T14:11:25Z
day: '29'
ddc:
- '580'
- '570'
department:
- _id: JiFr
- _id: EvBe
doi: 10.1371/journal.pone.0070069
ec_funded: 1
external_id:
  isi:
  - '000323369700128'
file:
- access_level: open_access
  checksum: 3be71828b6c2ba9c90eb7056e3f7f57a
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:16:34Z
  date_updated: 2020-07-14T12:45:41Z
  file_id: '5222'
  file_name: IST-2015-393-v1+1_journal.pone.0070069.pdf
  file_size: 9003465
  relation: main_file
file_date_updated: 2020-07-14T12:45:41Z
has_accepted_license: '1'
intvolume: '         8'
isi: 1
issue: '7'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
project:
- _id: 253FCA6A-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '207362'
  name: Hormonal cross-talk in plant organogenesis
- _id: 25716A02-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '282300'
  name: Polarity and subcellular dynamics in plants
publication: PLoS One
publication_status: published
publisher: Public Library of Science
publist_id: '4431'
pubrep_id: '393'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Role of the Arabidopsis PIN6 auxin transporter in auxin homeostasis and auxin-mediated
  development
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 8
year: '2013'
...