---
res:
  bibo_abstract:
  - Distribution of putative glutamatergic neurons in the lower brainstem and cerebellum
    of the rat was examined immunocytochemically by using a monoclonal antibody against
    phosphate-activated glutaminase, which has been proposed to be a major synthetic
    enzyme of transmitter glutamate and so may serve as a marker for glutamatergic
    neurons in the central nervous system. Intensely-immunolabeled neuronal cell bodies
    were densely distributed in the main precerebellar nuclei sending mossy fibers
    to the cerebellum; in the pontine nuclei, pontine tegmental reticular nucleus
    of Bechterew, external cuneate nucleus, and lateral reticular nucleus of the medulla
    oblongata. Phosphate-activated glutaminase-immunoreactive granular deposits were
    densely seen in the brachium pontis and restiform body, suggesting the immunolabeling
    of mossy fibers of passage. In the cerebellum, neuropil within the granule cell
    layer of the cerebellar cortex displayed intense phosphate-activated glutaminase-immunoreactivity,
    and that within the deep cerebellar nuclei showed moderate immunoreactivity. These
    results indicate that many mossy fiber terminals originate from phosphate-activated
    glutaminase-containing neurons and utilize phosphate-activated glutaminase for
    the synthesis of transmitter glutamate. Intensely-immunostained neuronal cell
    bodies were further observed in other regions which have been reported to contain
    neurons sending mossy fibers to the cerebellum; in the dorsal part of the principal
    sensory trigeminal nucleus, dorsomedial part of the oral subnucleus of the spinal
    trigeminal nucleus, interpolar subnucleus of the spinal trigeminal nucleus, paratrigeminal
    nucleus, supragenual nucleus, regions dorsal to the abducens nucleus and genu
    of the facial nerve, superior and medial vestibular nuclei, cell groups f, x and
    y, hypoglossal prepositus nucleus, intercalated nucleus, nucleus of Roller, reticular
    regions intercalated between the motor trigeminal and principal sensory trigeminal
    nuclei, linear nucleus, and gigantocellular and paramedian reticular formation.
    Neuronal cell bodies with intense phosphate-activated glutaminase-immunoreactivity
    were also found in other brainstem regions, such as the paracochlear glial substance,
    posterior ventral cochlear nucleus, and cell group e. Although it is still controversial
    whether all glutamatergic neurons use phosphate-activated glutaminase in a transmitter-related
    process and whether phosphate-activated glutaminase is involved in other metabolism-related
    processes, the neurons showing intense phosphate-activated glutaminase-immuno-reactivity
    in the present study were suggested to be putative glutamatergic neurons.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Takeshi
      foaf_name: Kaneko, Takeshi
      foaf_surname: Kaneko
  - foaf_Person:
      foaf_givenName: Kazuo
      foaf_name: Itoh, Kazuo
      foaf_surname: Itoh
  - foaf_Person:
      foaf_givenName: Ryuichi
      foaf_name: Shigemoto, Ryuichi
      foaf_surname: Shigemoto
      foaf_workInfoHomepage: http://www.librecat.org/personId=499F3ABC-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-8761-9444
  - foaf_Person:
      foaf_givenName: Noboru
      foaf_name: Mizuno, Noboru
      foaf_surname: Mizuno
  bibo_doi: 10.1016/0306-4522(89)90109-7
  bibo_issue: '1'
  bibo_volume: 32
  dct_date: 1989^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0306-4522
  - http://id.crossref.org/issn/1873-7544
  dct_language: eng
  dct_publisher: Elsevier@
  dct_title: Glutaminase-like immunoreactivity in the lower brainstem and cerebellum
    of the adult rat@
  fabio_hasPubmedId: '2586753'
...