---
_id: '2510'
abstract:
- lang: eng
  text: Neurons in the laterocapsular division of the central nucleus of the amygdala
    (CeC), which is known as the "nociceptive amygdala," receive glutamatergic
    inputs from the parabrachial nucleus (PB) and the basolateral nucleus of amygdala
    (BLA), which convey nociceptive information from the dorsal horn of the spinal
    cord and polymodal information from the thalamus and cortex, respectively. Here,
    we examined the ultrastructural properties of PB- and BLA-CeC synapses identified
    with EGFP-expressing lentivirus in rats. In addition, the density of synaptic
    AMPA receptors (AMPARs) on CeC neurons was studied by using highly sensitive SDS-digested
    freeze-fracture replica labeling (SDS-FRL). Afferents from the PB made asymmetrical
    synapses mainly on dendritic shafts (88%), whereas those from the BLA were on
    dendritic spines (81%). PB-CeC synapses in dendritic shafts were significantly
    larger (median 0.072 μm 2) than BLA-CeC synapses in spines (median 0.058 μm 2;
    P = 0.02). The dendritic shafts that made synapses with PB fibers were also significantly
    larger than those that made synapses with BLA fibers, indicating that the PB fibers
    make synapses on more proximal parts of dendrites than the BLA fibers. SDS-FRL
    revealed that almost all excitatory postsynaptic sites have AMPARs in the CeC.
    The density of AMPAR-specific gold particles in individual synapses was significantly
    higher in spine synapses (median 510 particles/μm 2) than in shaft synapses (median
    427 particles/μm 2; P = 0.01). These results suggest that distinct synaptic impacts
    from PB- and BLA-CeC pathways contribute to the integration of nociceptive and
    polymodal information in the CeC.
author:
- first_name: Yu
  full_name: Dong, Yu-Lin
  last_name: Dong
- first_name: Yugo
  full_name: Fukazawa, Yugo
  last_name: Fukazawa
- first_name: Wen
  full_name: Wang, Wen
  last_name: Wang
- first_name: Naomi
  full_name: Kamasawa, Naomi
  last_name: Kamasawa
- first_name: Ryuichi
  full_name: Ryuichi Shigemoto
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
citation:
  ama: Dong Y, Fukazawa Y, Wang W, Kamasawa N, Shigemoto R. Differential postsynaptic
    compartments in the laterocapsular division of the central nucleus of amygdala
    for afferents from the parabrachial nucleus and the basolateral nucleus in the
    rat. <i>Journal of Comparative Neurology</i>. 2010;518(23):4771-4791. doi:<a href="https://doi.org/10.1002/cne.22487">10.1002/cne.22487</a>
  apa: Dong, Y., Fukazawa, Y., Wang, W., Kamasawa, N., &#38; Shigemoto, R. (2010).
    Differential postsynaptic compartments in the laterocapsular division of the central
    nucleus of amygdala for afferents from the parabrachial nucleus and the basolateral
    nucleus in the rat. <i>Journal of Comparative Neurology</i>. Wiley-Blackwell.
    <a href="https://doi.org/10.1002/cne.22487">https://doi.org/10.1002/cne.22487</a>
  chicago: Dong, Yu, Yugo Fukazawa, Wen Wang, Naomi Kamasawa, and Ryuichi Shigemoto.
    “Differential Postsynaptic Compartments in the Laterocapsular Division of the
    Central Nucleus of Amygdala for Afferents from the Parabrachial Nucleus and the
    Basolateral Nucleus in the Rat.” <i>Journal of Comparative Neurology</i>. Wiley-Blackwell,
    2010. <a href="https://doi.org/10.1002/cne.22487">https://doi.org/10.1002/cne.22487</a>.
  ieee: Y. Dong, Y. Fukazawa, W. Wang, N. Kamasawa, and R. Shigemoto, “Differential
    postsynaptic compartments in the laterocapsular division of the central nucleus
    of amygdala for afferents from the parabrachial nucleus and the basolateral nucleus
    in the rat,” <i>Journal of Comparative Neurology</i>, vol. 518, no. 23. Wiley-Blackwell,
    pp. 4771–4791, 2010.
  ista: Dong Y, Fukazawa Y, Wang W, Kamasawa N, Shigemoto R. 2010. Differential postsynaptic
    compartments in the laterocapsular division of the central nucleus of amygdala
    for afferents from the parabrachial nucleus and the basolateral nucleus in the
    rat. Journal of Comparative Neurology. 518(23), 4771–4791.
  mla: Dong, Yu, et al. “Differential Postsynaptic Compartments in the Laterocapsular
    Division of the Central Nucleus of Amygdala for Afferents from the Parabrachial
    Nucleus and the Basolateral Nucleus in the Rat.” <i>Journal of Comparative Neurology</i>,
    vol. 518, no. 23, Wiley-Blackwell, 2010, pp. 4771–91, doi:<a href="https://doi.org/10.1002/cne.22487">10.1002/cne.22487</a>.
  short: Y. Dong, Y. Fukazawa, W. Wang, N. Kamasawa, R. Shigemoto, Journal of Comparative
    Neurology 518 (2010) 4771–4791.
date_created: 2018-12-11T11:58:05Z
date_published: 2010-12-01T00:00:00Z
date_updated: 2021-01-12T06:57:55Z
day: '01'
doi: 10.1002/cne.22487
extern: 1
intvolume: '       518'
issue: '23'
month: '12'
page: 4771 - 4791
publication: Journal of Comparative Neurology
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4391'
quality_controlled: 0
status: public
title: Differential postsynaptic compartments in the laterocapsular division of the
  central nucleus of amygdala for afferents from the parabrachial nucleus and the
  basolateral nucleus in the rat
type: journal_article
volume: 518
year: '2010'
...