---
res:
  bibo_abstract:
  - 'The metabotropic glutamate receptors are coupled to intracellular signal transduction
    via G-proteins and consist of a family of at least five different subtypes, termed
    mGluR1-mGluR5. We studied the signal transduction mechanism and pharmacological
    characteristics of the rat mGluR3 and mGluR4 subtypes in Chinese hamster ovary
    cells permanently expressing the cloned receptors. Both mGluR3 and mGluR4 inhibit
    the forskolin-stimulated accumulation of intracellular cAMP formation in response
    to agonist interaction. Consistent with the high degree of sequence similarity
    to mGluR2, mGluR3 closely resembles mGluR2 in its agonist selectivity; the potency
    rank order of agonists is L-glutamate > trans-1-aminocyclopentane- 1,3-dicarboxylate
    > ibotenate > quisqualate. mGluR4 is totally different in its agonist specificity
    from any other member of the metabotropic receptors. This receptor potently reacts
    with L-2-amino-4-phosphonobutyrate(L-AP4) in a stereo-selective manner and moderately
    responds to L-serine-O-phosphate. mGluR4 thus corresponds well to the putative
    L-AP4 receptor characterized from brain preparations. Blot and in situ hybridization
    analyses indicated that both mRNAs are widely distributed in the rat brain. mGluR3
    mRNA is highly expressed in neuronal cells of the cerebral cortex and the caudate-
    putamen, and in granule cells of the hippocampal dentate gyrus. The expression
    pattern of mGluR4 mRNA is more restricted, and this expression is prominent in
    the cerebellum, olfactory bulb, and thalamus. Furthermore, the mGluR3 mRNA, unlike
    the other mRNAs for the metabotropic receptors, is highly expressed in glial cells
    throughout the brain regions. The metabotropic glutamate receptor subtypes can
    thus be classified into three subgroups according to the similarity in their amino
    acid sequences, signal transduction, and agonist selectivity: mGluR1/mGluR5, mGluR2/mGluR3,
    and mGluR4. The mRNAs for the individual receptor subtypes, however, show overlapping
    but distinct patterns of expression in the rat CNS.@eng'
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Yasuto
      foaf_name: Tanabe, Yasuto
      foaf_surname: Tanabe
  - foaf_Person:
      foaf_givenName: Akinori
      foaf_name: Nomura, Akinori
      foaf_surname: Nomura
  - foaf_Person:
      foaf_givenName: Masayuki
      foaf_name: Masu, Masayuki
      foaf_surname: Masu
  - foaf_Person:
      foaf_givenName: Ryuichi
      foaf_name: Shigemoto, Ryuichi
      foaf_surname: Shigemoto
      foaf_workInfoHomepage: http://www.librecat.org/personId=499F3ABC-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-8761-9444
  - foaf_Person:
      foaf_givenName: Noboru
      foaf_name: Mizuno, Noboru
      foaf_surname: Mizuno
  - foaf_Person:
      foaf_givenName: Shigetada
      foaf_name: Nakanishi, Shigetada
      foaf_surname: Nakanishi
  bibo_doi: 10.1523/JNEUROSCI.13-04-01372.1993
  bibo_issue: '4'
  bibo_volume: 13
  dct_date: 1993^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0270-6474
  dct_language: eng
  dct_publisher: Society for Neuroscience@
  dct_title: Signal transduction, pharmacological properties, and expression patterns
    of two rat metabotropic glutamate receptors, mGluR3 and mGluR4@
  fabio_hasPubmedId: '8463825'
...