conference paper published Tomoo Hirano author Keizo Kasono author Ryuichi Shigemoto author 499F3ABC-F248-11E8-B48F-1D18A9856A870000-0001-8761-9444 Shigetada Nakanishi author Unknown (0388-6107) The induction mechanism of cerebellar long term depression (LTD) has been analysed in a cerebellar culture. Using nitr-5, a photolabile Ca chelator, we demonstrated that an increase in postsynaptic Ca together with glutamate application is sufficient to induce the LTD of glutamate responsiveness in Purkinje cells. It has also been shown that one subtype of genetically defined metabotropic glutamate receptor, mGluR1, is involved in the LTD induction. We raised antibodies which specifically recognized mGluR1 and inactivated its function. The antibodies suppressed the LTD induction in the cultured Purkinje cells. Biomedical Research Foundation1994 15SUPPL. 179 - 81 yes Hirano, Tomoo, Keizo Kasono, Ryuichi Shigemoto, and Shigetada Nakanishi. “Induction Mechanism of Long Term Depression in Cultured Purkinje Neurons,” 15:79–81. Biomedical Research Foundation, 1994. Hirano T, Kasono K, Shigemoto R, Nakanishi S. Induction mechanism of long term depression in cultured Purkinje neurons. In: Vol 15. Biomedical Research Foundation; 1994:79-81. T. Hirano, K. Kasono, R. Shigemoto, and S. Nakanishi, “Induction mechanism of long term depression in cultured Purkinje neurons,” presented at the Unknown (0388-6107), 1994, vol. 15, no. SUPPL. 1, pp. 79–81. Hirano, Tomoo, et al. <i>Induction Mechanism of Long Term Depression in Cultured Purkinje Neurons</i>. Vol. 15, no. SUPPL. 1, Biomedical Research Foundation, 1994, pp. 79–81. Hirano T, Kasono K, Shigemoto R, Nakanishi S. 1994. Induction mechanism of long term depression in cultured Purkinje neurons. Unknown (0388-6107), Biomedical Research, vol. 15, 79–81. Hirano, T., Kasono, K., Shigemoto, R., &#38; Nakanishi, S. (1994). Induction mechanism of long term depression in cultured Purkinje neurons (Vol. 15, pp. 79–81). Presented at the Unknown (0388-6107), Biomedical Research Foundation. T. Hirano, K. Kasono, R. Shigemoto, S. Nakanishi, in:, Biomedical Research Foundation, 1994, pp. 79–81. 25482018-12-11T11:58:19Z2021-01-12T06:58:10Z