article published yes Akinori Nomura author Ryuichi Shigemoto author 499F3ABC-F248-11E8-B48F-1D18A9856A870000-0001-8761-9444 Yasuhisa Nakamura author Naoyuki Okamoto author Noboru Mizuno author Shigetada Nakanishi author The retinal bipolar cell receiving glutamate transmission from photoreceptors mediates a key process in segregating visual signals into ON center and OFF center pathways. This transmission involves a G protein- coupled metabotropic glutamate receptor (mGluR). Immunocytochemical and immunoelectron microscopic studies indicate the restricted localization of a specific mGluR subtype, mGluR6, at the postsynaptic site of the rat rod bipolar cell. This specialization is developmentally regulated: mGluR6 is initially distributed in both the soma and dendrites and is finally concentrated on the postsynaptic site. The mGluR6 localization is reversed when photoreceptors degenerate in the mutant rat with retinal dystrophy. Evidence is thus presented indicating specialized, developmentally regulated receptor distribution in the central nervous system and the crucial role of mGluR6 in photoreceptor-bipolar cell synaptic transmission. Cell Press1994 eng 0092-8674 818105610.1016/0092-8674(94)90151-1 773361 - 369 yes A. Nomura, R. Shigemoto, Y. Nakamura, N. Okamoto, N. Mizuno, and S. Nakanishi, “Developmentally regulated postsynaptic localization of a metabotropic glutamate receptor in rat rod bipolar cells,” <i>Cell</i>, vol. 77, no. 3. Cell Press, pp. 361–369, 1994. Nomura, Akinori, et al. “Developmentally Regulated Postsynaptic Localization of a Metabotropic Glutamate Receptor in Rat Rod Bipolar Cells.” <i>Cell</i>, vol. 77, no. 3, Cell Press, 1994, pp. 361–69, doi:<a href="https://doi.org/10.1016/0092-8674(94)90151-1">10.1016/0092-8674(94)90151-1</a>. A. Nomura, R. Shigemoto, Y. Nakamura, N. Okamoto, N. Mizuno, S. Nakanishi, Cell 77 (1994) 361–369. Nomura, Akinori, Ryuichi Shigemoto, Yasuhisa Nakamura, Naoyuki Okamoto, Noboru Mizuno, and Shigetada Nakanishi. “Developmentally Regulated Postsynaptic Localization of a Metabotropic Glutamate Receptor in Rat Rod Bipolar Cells.” <i>Cell</i>. Cell Press, 1994. <a href="https://doi.org/10.1016/0092-8674(94)90151-1">https://doi.org/10.1016/0092-8674(94)90151-1</a>. Nomura A, Shigemoto R, Nakamura Y, Okamoto N, Mizuno N, Nakanishi S. 1994. Developmentally regulated postsynaptic localization of a metabotropic glutamate receptor in rat rod bipolar cells. Cell. 77(3), 361–369. Nomura A, Shigemoto R, Nakamura Y, Okamoto N, Mizuno N, Nakanishi S. Developmentally regulated postsynaptic localization of a metabotropic glutamate receptor in rat rod bipolar cells. <i>Cell</i>. 1994;77(3):361-369. doi:<a href="https://doi.org/10.1016/0092-8674(94)90151-1">10.1016/0092-8674(94)90151-1</a> Nomura, A., Shigemoto, R., Nakamura, Y., Okamoto, N., Mizuno, N., &#38; Nakanishi, S. (1994). Developmentally regulated postsynaptic localization of a metabotropic glutamate receptor in rat rod bipolar cells. <i>Cell</i>. Cell Press. <a href="https://doi.org/10.1016/0092-8674(94)90151-1">https://doi.org/10.1016/0092-8674(94)90151-1</a> 25542018-12-11T11:58:21Z2022-06-07T14:28:33Z