---
_id: '2554'
abstract:
- lang: eng
  text: 'The retinal bipolar cell receiving glutamate transmission from photoreceptors
    mediates a key process in segregating visual signals into ON center and OFF center
    pathways. This transmission involves a G protein- coupled metabotropic glutamate
    receptor (mGluR). Immunocytochemical and immunoelectron microscopic studies indicate
    the restricted localization of a specific mGluR subtype, mGluR6, at the postsynaptic
    site of the rat rod bipolar cell. This specialization is developmentally regulated:
    mGluR6 is initially distributed in both the soma and dendrites and is finally
    concentrated on the postsynaptic site. The mGluR6 localization is reversed when
    photoreceptors degenerate in the mutant rat with retinal dystrophy. Evidence is
    thus presented indicating specialized, developmentally regulated receptor distribution
    in the central nervous system and the crucial role of mGluR6 in photoreceptor-bipolar
    cell synaptic transmission.'
acknowledgement: "We thank M. Tachibana for technical advice concerning dissociated
  bipolar cell preparation, Y. Honda for advice \r\nconcerning RCS rat experiments,
  and A. Uesugi for photographic assistance. This work is partly supported by research
  grants from the Ministry of Education, Science, and Culture of Japan and from the
  Ministry of Health and Welfare of\r\nJapan. "
article_processing_charge: No
article_type: original
author:
- first_name: Akinori
  full_name: Nomura, Akinori
  last_name: Nomura
- first_name: Ryuichi
  full_name: Shigemoto, Ryuichi
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
- first_name: Yasuhisa
  full_name: Nakamura, Yasuhisa
  last_name: Nakamura
- first_name: Naoyuki
  full_name: Okamoto, Naoyuki
  last_name: Okamoto
- first_name: Noboru
  full_name: Mizuno, Noboru
  last_name: Mizuno
- first_name: Shigetada
  full_name: Nakanishi, Shigetada
  last_name: Nakanishi
citation:
  ama: Nomura A, Shigemoto R, Nakamura Y, Okamoto N, Mizuno N, Nakanishi S. Developmentally
    regulated postsynaptic localization of a metabotropic glutamate receptor in rat
    rod bipolar cells. <i>Cell</i>. 1994;77(3):361-369. doi:<a href="https://doi.org/10.1016/0092-8674(94)90151-1">10.1016/0092-8674(94)90151-1</a>
  apa: Nomura, A., Shigemoto, R., Nakamura, Y., Okamoto, N., Mizuno, N., &#38; Nakanishi,
    S. (1994). Developmentally regulated postsynaptic localization of a metabotropic
    glutamate receptor in rat rod bipolar cells. <i>Cell</i>. Cell Press. <a href="https://doi.org/10.1016/0092-8674(94)90151-1">https://doi.org/10.1016/0092-8674(94)90151-1</a>
  chicago: Nomura, Akinori, Ryuichi Shigemoto, Yasuhisa Nakamura, Naoyuki Okamoto,
    Noboru Mizuno, and Shigetada Nakanishi. “Developmentally Regulated Postsynaptic
    Localization of a Metabotropic Glutamate Receptor in Rat Rod Bipolar Cells.” <i>Cell</i>.
    Cell Press, 1994. <a href="https://doi.org/10.1016/0092-8674(94)90151-1">https://doi.org/10.1016/0092-8674(94)90151-1</a>.
  ieee: A. Nomura, R. Shigemoto, Y. Nakamura, N. Okamoto, N. Mizuno, and S. Nakanishi,
    “Developmentally regulated postsynaptic localization of a metabotropic glutamate
    receptor in rat rod bipolar cells,” <i>Cell</i>, vol. 77, no. 3. Cell Press, pp.
    361–369, 1994.
  ista: Nomura A, Shigemoto R, Nakamura Y, Okamoto N, Mizuno N, Nakanishi S. 1994.
    Developmentally regulated postsynaptic localization of a metabotropic glutamate
    receptor in rat rod bipolar cells. Cell. 77(3), 361–369.
  mla: Nomura, Akinori, et al. “Developmentally Regulated Postsynaptic Localization
    of a Metabotropic Glutamate Receptor in Rat Rod Bipolar Cells.” <i>Cell</i>, vol.
    77, no. 3, Cell Press, 1994, pp. 361–69, doi:<a href="https://doi.org/10.1016/0092-8674(94)90151-1">10.1016/0092-8674(94)90151-1</a>.
  short: A. Nomura, R. Shigemoto, Y. Nakamura, N. Okamoto, N. Mizuno, S. Nakanishi,
    Cell 77 (1994) 361–369.
date_created: 2018-12-11T11:58:21Z
date_published: 1994-05-06T00:00:00Z
date_updated: 2022-06-07T14:28:33Z
day: '06'
doi: 10.1016/0092-8674(94)90151-1
extern: '1'
external_id:
  pmid:
  - '8181056'
intvolume: '        77'
issue: '3'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/0092867494901511?via%3Dihub
month: '05'
oa_version: None
page: 361 - 369
pmid: 1
publication: Cell
publication_identifier:
  issn:
  - 0092-8674
publication_status: published
publisher: Cell Press
publist_id: '4344'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Developmentally regulated postsynaptic localization of a metabotropic glutamate
  receptor in rat rod bipolar cells
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 77
year: '1994'
...