--- res: bibo_abstract: - Taking advantage of the restricted expression of metabotropic glutamate receptor subtype 6 (mGIuR6) in retinal ON bipolar cells, we generated knockout mice lacking mGIuR6 expression. The homozygous mutant mice showed a loss of ON responses but unchanged OFF responses to light. The mutant mice displayed no obvious changes in retinal cell organization nor in the projection of optic fibers to the brain. Furthermore, the mGIuR6-deficient mice showed visual behavioral responses to light stimulation as examined by shuttle box avoidance behavior experiments using light exposure as a conditioned stimulus. The results demonstrate that mGIuR6 is essential in synaptic transmission to the ON bipolar cell and that the OFF response provides an important means for transmitting visual information.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Masayuki foaf_name: Masu, Masayuki foaf_surname: Masu - foaf_Person: foaf_givenName: Hideki foaf_name: Iwakabe, Hideki foaf_surname: Iwakabe - foaf_Person: foaf_givenName: Yoshiaki foaf_name: Tagawa, Yoshiaki foaf_surname: Tagawa - foaf_Person: foaf_givenName: Tomomitsu foaf_name: Miyoshi, Tomomitsu foaf_surname: Miyoshi - foaf_Person: foaf_givenName: Masayuki foaf_name: Yamashita, Masayuki foaf_surname: Yamashita - foaf_Person: foaf_givenName: Yutaka foaf_name: Fukuda, Yutaka foaf_surname: Fukuda - foaf_Person: foaf_givenName: Hitoshi foaf_name: Sasaki, Hitoshi foaf_surname: Sasaki - foaf_Person: foaf_givenName: Kano foaf_name: Hiroi, Kano foaf_surname: Hiroi - foaf_Person: foaf_givenName: Yasuhisa foaf_name: Nakamura, Yasuhisa foaf_surname: Nakamura - foaf_Person: foaf_givenName: Ryuichi foaf_name: Shigemoto, Ryuichi foaf_surname: Shigemoto foaf_workInfoHomepage: http://www.librecat.org/personId=499F3ABC-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0001-8761-9444 - foaf_Person: foaf_givenName: Masahiko foaf_name: Takada, Masahiko foaf_surname: Takada - foaf_Person: foaf_givenName: Kenji foaf_name: Nakamura, Kenji foaf_surname: Nakamura - foaf_Person: foaf_givenName: Kazuki foaf_name: Nakao, Kazuki foaf_surname: Nakao - foaf_Person: foaf_givenName: Motoya foaf_name: Katsuki, Motoya foaf_surname: Katsuki - foaf_Person: foaf_givenName: Shigetada foaf_name: Nakanishi, Shigetada foaf_surname: Nakanishi bibo_doi: 10.1016/0092-8674(95)90354-2 bibo_issue: '5' bibo_volume: 80 dct_date: 1995^xs_gYear dct_isPartOf: - http://id.crossref.org/issn/0092-8674 dct_language: eng dct_publisher: Cell Press@ dct_title: Specific deficit of the ON response in visual transmission by targeted disruption of the mGIuR6 gene@ fabio_hasPubmedId: '7889569' ...