{"issue":"6582","author":[{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","full_name":"Shigemoto, Ryuichi","last_name":"Shigemoto"},{"full_name":"Kulik, Ákos","first_name":"Ákos","last_name":"Kulik"},{"last_name":"Roberts","full_name":"Roberts, John","first_name":"John"},{"last_name":"Ohishi","first_name":"Hitoshi","full_name":"Ohishi, Hitoshi"},{"last_name":"Nusser","full_name":"Nusser, Zoltán","first_name":"Zoltán"},{"first_name":"Takeshi","full_name":"Kaneko, Takeshi","last_name":"Kaneko"},{"last_name":"Somogyi","first_name":"Péter","full_name":"Somogyi, Péter"}],"article_processing_charge":"No","intvolume":"       381","oa_version":"None","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","doi":"10.1038/381523a0","date_updated":"2022-08-11T14:45:35Z","publication_identifier":{"issn":["0028-0836"]},"abstract":[{"text":"The probability of synaptic neurotransmitter release from nerve terminals is regulated by presynaptic receptors responding to transmitters released from the same nerve terminal or from terminals of other neurons. The release of glutamate, the major excitatory neurotransmitter, is suppressed by presynaptic auto receptors. Here we show that a metabotropic glutamate receptor (mGluR7) in the rat hippocampus is restricted to the presynaptic grid, the site of synaptic vesicle fusion. Pyramidal cell terminals presynaptic to mGluR1α-expressing interneurons have at least a ten-fold higher level of presynaptic mGluR7 than terminals making synapses with pyramidal cells and other types of interneuron. Distinct levels of mGluR7 are found at different synapses made by individual pyramidal axons or even single boutons. These results raise the possibility that presynaptic neurons could regulate the probability of transmitter release at individual synapses according to the postsynaptic target","lang":"eng"}],"date_published":"1996-06-06T00:00:00Z","_id":"2570","publication":"Nature","external_id":{"pmid":["8632825 "]},"status":"public","article_type":"original","volume":381,"day":"06","scopus_import":"1","type":"journal_article","publisher":"Nature Publishing Group","publist_id":"4328","publication_status":"published","language":[{"iso":"eng"}],"month":"06","acknowledgement":"We thank E. Molnar for help in immunoblotting; A. D. Smith for comments on the manuscript; D. Latawiec fortechnical assistance; and P. Jays and F. Kennedy for photographic assistance. This work was partly supported by the Ministry of Education, Science and Culture of Japan. AK. is supported by the MHB MagyarTudomanyert Foundation and the OTKA Foundation of the Hungarian Government. ","quality_controlled":"1","title":"Target-cell-specific concentration of a metabotropic glutamate receptor in the presynaptic active zone","page":"523 - 525","date_created":"2018-12-11T11:58:26Z","pmid":1,"year":"1996","extern":"1","citation":{"chicago":"Shigemoto, Ryuichi, Ákos Kulik, John Roberts, Hitoshi Ohishi, Zoltán Nusser, Takeshi Kaneko, and Péter Somogyi. “Target-Cell-Specific Concentration of a Metabotropic Glutamate Receptor in the Presynaptic Active Zone.” <i>Nature</i>. Nature Publishing Group, 1996. <a href=\"https://doi.org/10.1038/381523a0\">https://doi.org/10.1038/381523a0</a>.","ista":"Shigemoto R, Kulik Á, Roberts J, Ohishi H, Nusser Z, Kaneko T, Somogyi P. 1996. Target-cell-specific concentration of a metabotropic glutamate receptor in the presynaptic active zone. Nature. 381(6582), 523–525.","apa":"Shigemoto, R., Kulik, Á., Roberts, J., Ohishi, H., Nusser, Z., Kaneko, T., &#38; Somogyi, P. (1996). Target-cell-specific concentration of a metabotropic glutamate receptor in the presynaptic active zone. <i>Nature</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/381523a0\">https://doi.org/10.1038/381523a0</a>","ieee":"R. Shigemoto <i>et al.</i>, “Target-cell-specific concentration of a metabotropic glutamate receptor in the presynaptic active zone,” <i>Nature</i>, vol. 381, no. 6582. Nature Publishing Group, pp. 523–525, 1996.","mla":"Shigemoto, Ryuichi, et al. “Target-Cell-Specific Concentration of a Metabotropic Glutamate Receptor in the Presynaptic Active Zone.” <i>Nature</i>, vol. 381, no. 6582, Nature Publishing Group, 1996, pp. 523–25, doi:<a href=\"https://doi.org/10.1038/381523a0\">10.1038/381523a0</a>.","ama":"Shigemoto R, Kulik Á, Roberts J, et al. Target-cell-specific concentration of a metabotropic glutamate receptor in the presynaptic active zone. <i>Nature</i>. 1996;381(6582):523-525. doi:<a href=\"https://doi.org/10.1038/381523a0\">10.1038/381523a0</a>","short":"R. Shigemoto, Á. Kulik, J. Roberts, H. Ohishi, Z. Nusser, T. Kaneko, P. Somogyi, Nature 381 (1996) 523–525."}}