---
res:
  bibo_abstract:
  - In cat and monkey, lamina I cells can be classified into three basic morphological
    types (fusiform, pyramidal, and multipolar), and recent intracellular labeling
    evidence in the cat indicates that fusiform and multipolar lamina I cells are
    two different types of nociceptive cells, whereas pyramidal cells are innocuous
    thermoreceptive-specific. Because earlier observations indicated that only nociceptive
    dorsal horn neurons respond to substance P (SP), we examined which morphological
    types of lamina I neurons express receptors for SP (NK-1r). We categorized NK-1r-
    immunoreactive (IR) lamina I neurons in serial horizontal sections from the cervical
    and lumbar enlargements of four monkeys. Consistent results were obtained by two
    independent teams of observers. Nearly all NK-1r-IR cells were fusiform (42%)
    or multipolar (43%), but only 6% were pyramidal (with 9% unclassified). We obtained
    similar findings in three monkeys in which we used double-labeling immunocytochemistry
    to identify NK-1r-IR and spinothalamic lamina I neurons retrogradely labeled with
    cholera toxin subunit b from the thalamus; most NK-1r-IR lamina I spinothalamic
    neurons were fusiform (48%) or multipolar (33%), and only 10% were pyramidal.
    In contrast, most (~75%) pyramidal and some (~25%) fusiform and multipolar lamina
    I spinothalamic neurons did not display NK-1r immunoreactivity. These data indicate
    that most fusiform and multipolar lamina I neurons in the monkey can express NK-1r,
    consistent with the idea that both types are nociceptive, whereas only a small
    proportion of lamina I pyramidal cells express this receptor, consistent with
    the previous finding that they are nonnociceptive. However, these findings also
    indicate that not all nociceptive lamina I neurons express receptors for SP.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Xiao
      foaf_name: Yu, Xiao
      foaf_surname: Yu
  - foaf_Person:
      foaf_givenName: En
      foaf_name: Zhang, En
      foaf_surname: Zhang
  - foaf_Person:
      foaf_givenName: Arthur
      foaf_name: Craig, Arthur
      foaf_surname: Craig
  - foaf_Person:
      foaf_givenName: Ryuichi
      foaf_name: Shigemoto, Ryuichi
      foaf_surname: Shigemoto
      foaf_workInfoHomepage: http://www.librecat.org/personId=499F3ABC-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-8761-9444
  - foaf_Person:
      foaf_givenName: Alfredo
      foaf_name: Ribeiro Da Silva, Alfredo
      foaf_surname: Ribeiro Da Silva
  - foaf_Person:
      foaf_givenName: Yves
      foaf_name: De Koninck, Yves
      foaf_surname: De Koninck
  bibo_doi: 10.1523/JNEUROSCI.19-09-03545.1999
  bibo_issue: '9'
  bibo_volume: 19
  dct_date: 1999^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0270-6474
  dct_language: eng
  dct_publisher: Society for Neuroscience@
  dct_title: NK-1 receptor immunoreactivity in distinct morphological types of lamina
    I neurons of the primate spinal cord@
  fabio_hasPubmedId: '10212314'
...