---
_id: '2593'
abstract:
- lang: eng
  text: In cat and monkey, lamina I cells can be classified into three basic morphological
    types (fusiform, pyramidal, and multipolar), and recent intracellular labeling
    evidence in the cat indicates that fusiform and multipolar lamina I cells are
    two different types of nociceptive cells, whereas pyramidal cells are innocuous
    thermoreceptive-specific. Because earlier observations indicated that only nociceptive
    dorsal horn neurons respond to substance P (SP), we examined which morphological
    types of lamina I neurons express receptors for SP (NK-1r). We categorized NK-1r-
    immunoreactive (IR) lamina I neurons in serial horizontal sections from the cervical
    and lumbar enlargements of four monkeys. Consistent results were obtained by two
    independent teams of observers. Nearly all NK-1r-IR cells were fusiform (42%)
    or multipolar (43%), but only 6% were pyramidal (with 9% unclassified). We obtained
    similar findings in three monkeys in which we used double-labeling immunocytochemistry
    to identify NK-1r-IR and spinothalamic lamina I neurons retrogradely labeled with
    cholera toxin subunit b from the thalamus; most NK-1r-IR lamina I spinothalamic
    neurons were fusiform (48%) or multipolar (33%), and only 10% were pyramidal.
    In contrast, most (~75%) pyramidal and some (~25%) fusiform and multipolar lamina
    I spinothalamic neurons did not display NK-1r immunoreactivity. These data indicate
    that most fusiform and multipolar lamina I neurons in the monkey can express NK-1r,
    consistent with the idea that both types are nociceptive, whereas only a small
    proportion of lamina I pyramidal cells express this receptor, consistent with
    the previous finding that they are nonnociceptive. However, these findings also
    indicate that not all nociceptive lamina I neurons express receptors for SP.
acknowledgement: This study was supported by National Institute of Health Grants NS
  34022 to Y.D.K. and NS 25616 to A.D.C., by Canadian Medical Research Council (MRC)
  Grants MT 12942 to Y.D.K. and MT 12170 to A.R.S., and by the Barrow Neurological
  Foundation. Y.D.K. is a Scholar of the Canadian MRC. We thank A. Constantin and
  A. Forster for expert technical assistance and Dr. M. Wikstrom for generously supplying
  monoclonal antibodies against CTb.
article_processing_charge: No
article_type: original
author:
- first_name: Xiao
  full_name: Yu, Xiao
  last_name: Yu
- first_name: En
  full_name: Zhang, En
  last_name: Zhang
- first_name: Arthur
  full_name: Craig, Arthur
  last_name: Craig
- first_name: Ryuichi
  full_name: Shigemoto, Ryuichi
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
- first_name: Alfredo
  full_name: Ribeiro Da Silva, Alfredo
  last_name: Ribeiro Da Silva
- first_name: Yves
  full_name: De Koninck, Yves
  last_name: De Koninck
citation:
  ama: Yu X, Zhang E, Craig A, Shigemoto R, Ribeiro Da Silva A, De Koninck Y. NK-1
    receptor immunoreactivity in distinct morphological types of lamina I neurons
    of the primate spinal cord. <i>Journal of Neuroscience</i>. 1999;19(9):3545-3555.
    doi:<a href="https://doi.org/10.1523/JNEUROSCI.19-09-03545.1999">10.1523/JNEUROSCI.19-09-03545.1999</a>
  apa: Yu, X., Zhang, E., Craig, A., Shigemoto, R., Ribeiro Da Silva, A., &#38; De
    Koninck, Y. (1999). NK-1 receptor immunoreactivity in distinct morphological types
    of lamina I neurons of the primate spinal cord. <i>Journal of Neuroscience</i>.
    Society for Neuroscience. <a href="https://doi.org/10.1523/JNEUROSCI.19-09-03545.1999">https://doi.org/10.1523/JNEUROSCI.19-09-03545.1999</a>
  chicago: Yu, Xiao, En Zhang, Arthur Craig, Ryuichi Shigemoto, Alfredo Ribeiro Da
    Silva, and Yves De Koninck. “NK-1 Receptor Immunoreactivity in Distinct Morphological
    Types of Lamina I Neurons of the Primate Spinal Cord.” <i>Journal of Neuroscience</i>.
    Society for Neuroscience, 1999. <a href="https://doi.org/10.1523/JNEUROSCI.19-09-03545.1999">https://doi.org/10.1523/JNEUROSCI.19-09-03545.1999</a>.
  ieee: X. Yu, E. Zhang, A. Craig, R. Shigemoto, A. Ribeiro Da Silva, and Y. De Koninck,
    “NK-1 receptor immunoreactivity in distinct morphological types of lamina I neurons
    of the primate spinal cord,” <i>Journal of Neuroscience</i>, vol. 19, no. 9. Society
    for Neuroscience, pp. 3545–3555, 1999.
  ista: Yu X, Zhang E, Craig A, Shigemoto R, Ribeiro Da Silva A, De Koninck Y. 1999.
    NK-1 receptor immunoreactivity in distinct morphological types of lamina I neurons
    of the primate spinal cord. Journal of Neuroscience. 19(9), 3545–3555.
  mla: Yu, Xiao, et al. “NK-1 Receptor Immunoreactivity in Distinct Morphological
    Types of Lamina I Neurons of the Primate Spinal Cord.” <i>Journal of Neuroscience</i>,
    vol. 19, no. 9, Society for Neuroscience, 1999, pp. 3545–55, doi:<a href="https://doi.org/10.1523/JNEUROSCI.19-09-03545.1999">10.1523/JNEUROSCI.19-09-03545.1999</a>.
  short: X. Yu, E. Zhang, A. Craig, R. Shigemoto, A. Ribeiro Da Silva, Y. De Koninck,
    Journal of Neuroscience 19 (1999) 3545–3555.
date_created: 2018-12-11T11:58:34Z
date_published: 1999-05-01T00:00:00Z
date_updated: 2023-03-27T09:54:40Z
day: '01'
doi: 10.1523/JNEUROSCI.19-09-03545.1999
extern: '1'
external_id:
  pmid:
  - '10212314'
fulldoi: https://doi.org/10.1523/JNEUROSCI.19-09-03545.1999
intvolume: '        19'
issue: '9'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782224/
month: '05'
oa: 1
oa_version: None
page: 3545 - 3555
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
  issn:
  - 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '4305'
quality_controlled: '1'
scopus_import: '1'
status: public
title: NK-1 receptor immunoreactivity in distinct morphological types of lamina I
  neurons of the primate spinal cord
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...