{"author":[{"last_name":"Li","full_name":"Li, Jin","first_name":"Jin"},{"last_name":"Wang","full_name":"Wang, Dan","first_name":"Dan"},{"first_name":"Takeshi","full_name":"Kaneko, Takeshi","last_name":"Kaneko"},{"full_name":"Shigemoto, Ryuichi","last_name":"Shigemoto","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444"},{"full_name":"Nomura, Sakashi","last_name":"Nomura","first_name":"Sakashi"},{"full_name":"Mizuno, Noboru","last_name":"Mizuno","first_name":"Noboru"}],"language":[{"iso":"eng"}],"date_updated":"2023-05-03T10:47:06Z","date_created":"2018-12-11T11:58:36Z","pmid":1,"title":"The relationship between neurokinin-1 receptor and substance P in the medullary dorsal horn: A light and electron microscopic immunohistochemical study in the rat","article_type":"original","date_published":"2000-04-01T00:00:00Z","oa_version":"None","scopus_import":"1","issue":"4","extern":"1","publication_identifier":{"issn":["0168-0102"]},"citation":{"chicago":"Li, Jin, Dan Wang, Takeshi Kaneko, Ryuichi Shigemoto, Sakashi Nomura, and Noboru Mizuno. “The Relationship between Neurokinin-1 Receptor and Substance P in the Medullary Dorsal Horn: A Light and Electron Microscopic Immunohistochemical Study in the Rat.” <i>Neuroscience Research</i>. Elsevier, 2000. <a href=\"https://doi.org/10.1016/S0168-0102(00)00095-X\">https://doi.org/10.1016/S0168-0102(00)00095-X</a>.","apa":"Li, J., Wang, D., Kaneko, T., Shigemoto, R., Nomura, S., &#38; Mizuno, N. (2000). The relationship between neurokinin-1 receptor and substance P in the medullary dorsal horn: A light and electron microscopic immunohistochemical study in the rat. <i>Neuroscience Research</i>. Elsevier. <a href=\"https://doi.org/10.1016/S0168-0102(00)00095-X\">https://doi.org/10.1016/S0168-0102(00)00095-X</a>","mla":"Li, Jin, et al. “The Relationship between Neurokinin-1 Receptor and Substance P in the Medullary Dorsal Horn: A Light and Electron Microscopic Immunohistochemical Study in the Rat.” <i>Neuroscience Research</i>, vol. 36, no. 4, Elsevier, 2000, pp. 327–34, doi:<a href=\"https://doi.org/10.1016/S0168-0102(00)00095-X\">10.1016/S0168-0102(00)00095-X</a>.","ieee":"J. Li, D. Wang, T. Kaneko, R. Shigemoto, S. Nomura, and N. Mizuno, “The relationship between neurokinin-1 receptor and substance P in the medullary dorsal horn: A light and electron microscopic immunohistochemical study in the rat,” <i>Neuroscience Research</i>, vol. 36, no. 4. Elsevier, pp. 327–334, 2000.","short":"J. Li, D. Wang, T. Kaneko, R. Shigemoto, S. Nomura, N. Mizuno, Neuroscience Research 36 (2000) 327–334.","ama":"Li J, Wang D, Kaneko T, Shigemoto R, Nomura S, Mizuno N. The relationship between neurokinin-1 receptor and substance P in the medullary dorsal horn: A light and electron microscopic immunohistochemical study in the rat. <i>Neuroscience Research</i>. 2000;36(4):327-334. doi:<a href=\"https://doi.org/10.1016/S0168-0102(00)00095-X\">10.1016/S0168-0102(00)00095-X</a>","ista":"Li J, Wang D, Kaneko T, Shigemoto R, Nomura S, Mizuno N. 2000. The relationship between neurokinin-1 receptor and substance P in the medullary dorsal horn: A light and electron microscopic immunohistochemical study in the rat. Neuroscience Research. 36(4), 327–334."},"abstract":[{"text":"The synaptic relationship between substance P (SP) and its receptor, i.e. neurokinin-1 receptor (NK1R), was examined in the superficial laminae of the caudal subnucleus of the spinal trigeminal nucleus (medullary dorsal horn; MDH) of the rat. For confocal laser-scanning microscopy, double-immunofluorescence histochemistry for NK1 and SP was performed. In electron microscopic double-immunolabeling study, immunoreactivity for NK1R was detected with the silver-intensified gold method, while immunoreactivity for SP was detected with peroxidase immunohistochemistry. SP-immunoreactive axon terminals were observed to be in synaptic (mostly asymmetric) contact with NK1R-immunoreactive neuronal profiles in lamina I and lamina IIo. Although some SP-immunoreactive axon terminals were in synaptic contact with NK1R-immunoreactive sites of plasma membranes, NK1R-immunoreactivity was observed at both synaptic and non-synaptic sites of plasma membrane. Thus, SP released from axon terminals might not only act on NK1Rs facing the SP-containing axon terminals, but also diffuse in the extracellular fluid for distances larger than the synaptic cleft to act on NK1Rs at some distances from the synaptic sites. ","lang":"eng"}],"publication":"Neuroscience Research","_id":"2600","page":"327 - 334","type":"journal_article","article_processing_charge":"No","doi":"10.1016/S0168-0102(00)00095-X","quality_controlled":"1","intvolume":"        36","volume":36,"publication_status":"published","status":"public","month":"04","day":"01","year":"2000","publist_id":"4298","publisher":"Elsevier","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","external_id":{"pmid":["10771111"]}}