---
res:
  bibo_abstract:
  - Targeted deletion of metabotropic glutamate receptor-subtype 1 (mGluR1) gene can
    cause defects in development and function in the cerebellum. We introduced the
    mGluR1α transgene into mGluR1-null mutant [mGluR1 (-/-)] mice with a Purkinje
    cell (PC)-specific promoter. mGluR1-rescue mice showed normal cerebellar long-term
    depression and regression of multiple climbing fiber innervation, events significantly
    impaired in mGluR1 (-/-) mice. The impaired motor coordination was rescued by
    this transgene, in a dose-dependent manner. We propose that mGluR1 in PCs is a
    key molecule for normal synapse formation, synaptic plasticity, and motor control
    in the cerebellum.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Taeko
      foaf_name: Ichise, Taeko
      foaf_surname: Ichise
  - foaf_Person:
      foaf_givenName: Masanobu
      foaf_name: Kano, Masanobu
      foaf_surname: Kano
  - foaf_Person:
      foaf_givenName: Kouichi
      foaf_name: Hashimoto, Kouichi
      foaf_surname: Hashimoto
  - foaf_Person:
      foaf_givenName: Dai
      foaf_name: Yanagihara, Dai
      foaf_surname: Yanagihara
  - foaf_Person:
      foaf_givenName: Kazuki
      foaf_name: Nakao, Kazuki
      foaf_surname: Nakao
  - foaf_Person:
      foaf_givenName: Ryuichi
      foaf_name: Shigemoto, Ryuichi
      foaf_surname: Shigemoto
      foaf_workInfoHomepage: http://www.librecat.org/personId=499F3ABC-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-8761-9444
  - foaf_Person:
      foaf_givenName: Motoya
      foaf_name: Katsuki, Motoya
      foaf_surname: Katsuki
  - foaf_Person:
      foaf_givenName: Atsu
      foaf_name: Aiba, Atsu
      foaf_surname: Aiba
  bibo_doi: 10.1126/science.288.5472.1832
  bibo_issue: '5472'
  bibo_volume: 288
  dct_date: 2000^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0036-8075
  dct_language: eng
  dct_publisher: American Association for the Advancement of Science@
  dct_title: mGluR1 in cerebellar Purkinje cells essential for long-term depression,
    synapse elimination, and motor coordination@
  fabio_hasPubmedId: '10846166 '
...