{"publisher":"American Association for the Advancement of Science","author":[{"first_name":"Taeko","full_name":"Ichise, Taeko","last_name":"Ichise"},{"full_name":"Kano, Masanobu","first_name":"Masanobu","last_name":"Kano"},{"full_name":"Hashimoto, Kouichi","first_name":"Kouichi","last_name":"Hashimoto"},{"full_name":"Yanagihara, Dai","first_name":"Dai","last_name":"Yanagihara"},{"last_name":"Nakao","full_name":"Nakao, Kazuki","first_name":"Kazuki"},{"last_name":"Shigemoto","orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi","first_name":"Ryuichi"},{"last_name":"Katsuki","first_name":"Motoya","full_name":"Katsuki, Motoya"},{"full_name":"Aiba, Atsu","first_name":"Atsu","last_name":"Aiba"}],"oa_version":"None","publication_identifier":{"issn":["0036-8075"]},"month":"06","date_published":"2000-06-09T00:00:00Z","article_processing_charge":"No","publication_status":"published","publication":"Science","_id":"2601","day":"09","status":"public","date_created":"2018-12-11T11:58:36Z","scopus_import":"1","external_id":{"pmid":["10846166 "]},"language":[{"iso":"eng"}],"page":"1832 - 1835","abstract":[{"text":"Targeted deletion of metabotropic glutamate receptor-subtype 1 (mGluR1) gene can cause defects in development and function in the cerebellum. We introduced the mGluR1α transgene into mGluR1-null mutant [mGluR1 (-/-)] mice with a Purkinje cell (PC)-specific promoter. mGluR1-rescue mice showed normal cerebellar long-term depression and regression of multiple climbing fiber innervation, events significantly impaired in mGluR1 (-/-) mice. The impaired motor coordination was rescued by this transgene, in a dose-dependent manner. We propose that mGluR1 in PCs is a key molecule for normal synapse formation, synaptic plasticity, and motor control in the cerebellum.","lang":"eng"}],"quality_controlled":"1","issue":"5472","year":"2000","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","volume":288,"date_updated":"2023-05-03T09:53:38Z","publist_id":"4297","pmid":1,"article_type":"original","extern":"1","intvolume":"       288","type":"journal_article","title":"mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination","doi":"10.1126/science.288.5472.1832","citation":{"mla":"Ichise, Taeko, et al. “MGluR1 in Cerebellar Purkinje Cells Essential for Long-Term Depression, Synapse Elimination, and Motor Coordination.” <i>Science</i>, vol. 288, no. 5472, American Association for the Advancement of Science, 2000, pp. 1832–35, doi:<a href=\"https://doi.org/10.1126/science.288.5472.1832\">10.1126/science.288.5472.1832</a>.","chicago":"Ichise, Taeko, Masanobu Kano, Kouichi Hashimoto, Dai Yanagihara, Kazuki Nakao, Ryuichi Shigemoto, Motoya Katsuki, and Atsu Aiba. “MGluR1 in Cerebellar Purkinje Cells Essential for Long-Term Depression, Synapse Elimination, and Motor Coordination.” <i>Science</i>. American Association for the Advancement of Science, 2000. <a href=\"https://doi.org/10.1126/science.288.5472.1832\">https://doi.org/10.1126/science.288.5472.1832</a>.","short":"T. Ichise, M. Kano, K. Hashimoto, D. Yanagihara, K. Nakao, R. Shigemoto, M. Katsuki, A. Aiba, Science 288 (2000) 1832–1835.","ista":"Ichise T, Kano M, Hashimoto K, Yanagihara D, Nakao K, Shigemoto R, Katsuki M, Aiba A. 2000. mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination. Science. 288(5472), 1832–1835.","ieee":"T. Ichise <i>et al.</i>, “mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination,” <i>Science</i>, vol. 288, no. 5472. American Association for the Advancement of Science, pp. 1832–1835, 2000.","ama":"Ichise T, Kano M, Hashimoto K, et al. mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination. <i>Science</i>. 2000;288(5472):1832-1835. doi:<a href=\"https://doi.org/10.1126/science.288.5472.1832\">10.1126/science.288.5472.1832</a>","apa":"Ichise, T., Kano, M., Hashimoto, K., Yanagihara, D., Nakao, K., Shigemoto, R., … Aiba, A. (2000). mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.288.5472.1832\">https://doi.org/10.1126/science.288.5472.1832</a>"}}