article published yes Taeko Ichise author Masanobu Kano author Kouichi Hashimoto author Dai Yanagihara author Kazuki Nakao author Ryuichi Shigemoto author 499F3ABC-F248-11E8-B48F-1D18A9856A870000-0001-8761-9444 Motoya Katsuki author Atsu Aiba author Targeted deletion of metabotropic glutamate receptor-subtype 1 (mGluR1) gene can cause defects in development and function in the cerebellum. We introduced the mGluR1α transgene into mGluR1-null mutant [mGluR1 (-/-)] mice with a Purkinje cell (PC)-specific promoter. mGluR1-rescue mice showed normal cerebellar long-term depression and regression of multiple climbing fiber innervation, events significantly impaired in mGluR1 (-/-) mice. The impaired motor coordination was rescued by this transgene, in a dose-dependent manner. We propose that mGluR1 in PCs is a key molecule for normal synapse formation, synaptic plasticity, and motor control in the cerebellum. American Association for the Advancement of Science2000 eng 0036-8075 10846166 10.1126/science.288.5472.1832 28854721832 - 1835 yes Ichise, Taeko, Masanobu Kano, Kouichi Hashimoto, Dai Yanagihara, Kazuki Nakao, Ryuichi Shigemoto, Motoya Katsuki, and Atsu Aiba. “MGluR1 in Cerebellar Purkinje Cells Essential for Long-Term Depression, Synapse Elimination, and Motor Coordination.” <i>Science</i>. American Association for the Advancement of Science, 2000. <a href="https://doi.org/10.1126/science.288.5472.1832">https://doi.org/10.1126/science.288.5472.1832</a>. Ichise T, Kano M, Hashimoto K, Yanagihara D, Nakao K, Shigemoto R, Katsuki M, Aiba A. 2000. mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination. Science. 288(5472), 1832–1835. T. Ichise <i>et al.</i>, “mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination,” <i>Science</i>, vol. 288, no. 5472. American Association for the Advancement of Science, pp. 1832–1835, 2000. Ichise T, Kano M, Hashimoto K, et al. mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination. <i>Science</i>. 2000;288(5472):1832-1835. doi:<a href="https://doi.org/10.1126/science.288.5472.1832">10.1126/science.288.5472.1832</a> Ichise, T., Kano, M., Hashimoto, K., Yanagihara, D., Nakao, K., Shigemoto, R., … Aiba, A. (2000). mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination. <i>Science</i>. American Association for the Advancement of Science. <a href="https://doi.org/10.1126/science.288.5472.1832">https://doi.org/10.1126/science.288.5472.1832</a> T. Ichise, M. Kano, K. Hashimoto, D. Yanagihara, K. Nakao, R. Shigemoto, M. Katsuki, A. Aiba, Science 288 (2000) 1832–1835. Ichise, Taeko, et al. “MGluR1 in Cerebellar Purkinje Cells Essential for Long-Term Depression, Synapse Elimination, and Motor Coordination.” <i>Science</i>, vol. 288, no. 5472, American Association for the Advancement of Science, 2000, pp. 1832–35, doi:<a href="https://doi.org/10.1126/science.288.5472.1832">10.1126/science.288.5472.1832</a>. 26012018-12-11T11:58:36Z2023-05-03T09:53:38Z