---
res:
  bibo_abstract:
  - Although presynaptic localization of mGluR7 is well established, the mechanism
    by which the receptor may control Ca2+ channels in neurons is still unknown. We
    show here that cultured cerebellar granule cells express native metabotropic glutamate
    receptor type 7 (mGluR7) in neuritic processes, whereas transfected mGluR7 was
    also expressed in cell bodies. This allowed us to study the effect of the transfected
    receptor on somatic Ca2+ channels. In transfected neurons, mGuR7 selectively inhibited
    P/Q-type Ca2+ channels. The effect was mimicked by GTPγS and blocked by pertussis
    toxin (PTX) or a selective antibody raised against the G-protein αo subunit, indicating
    the involvement of a G(o)-like protein. The mGuR7 effect did not display the characteristics
    of a direct interaction between G-protein βγ subunits and the α1A Ca2+ channel
    subunit, but was abolished by quenching βγ subunits with specific intracellular
    peptides. Intracellular dialysis of G-protein βγ subunits did not mimic the action
    of mGluR7, suggesting that both G-protein βγ and αo subunits were required to
    mediate the effect. Inhibition of phospholipase C (PLC) blocked the inhibitory
    action of mGluR7, suggesting that a coincident activation of PLC by the G-protein
    βγ with αo subunits was required. The Ca2+ chelator BAPTA, as well as inhibition
    of either the inositol trisphosphate (IP3) receptor or protein kinase C (PKC)
    abolished the mGluR7 effect. Moreover, activation of native mGluR7 induced a PTX-dependent
    IP3 formation. These results indicated that IP3-mediated intracellular Ca2+ release
    was required for PKC-dependent inhibition of the Ca2+ channels. Possible control
    of synaptic transmission by the present mechanisms is discussed.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Julie
      foaf_name: Perroy, Julie
      foaf_surname: Perroy
  - foaf_Person:
      foaf_givenName: Laurent
      foaf_name: Prezèau, Laurent
      foaf_surname: Prezèau
  - foaf_Person:
      foaf_givenName: Michel
      foaf_name: De Waard, Michel
      foaf_surname: De Waard
  - foaf_Person:
      foaf_givenName: Ryuichi
      foaf_name: Shigemoto, Ryuichi
      foaf_surname: Shigemoto
      foaf_workInfoHomepage: http://www.librecat.org/personId=499F3ABC-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-8761-9444
  - foaf_Person:
      foaf_givenName: Joël
      foaf_name: Bockaërt, Joël
      foaf_surname: Bockaërt
  - foaf_Person:
      foaf_givenName: Laurent
      foaf_name: Fagni, Laurent
      foaf_surname: Fagni
  bibo_doi: 10.1523/JNEUROSCI.20-21-07896.2000
  bibo_issue: '21'
  bibo_volume: 20
  dct_date: 2000^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0270-6474
  dct_language: eng
  dct_publisher: Society for Neuroscience@
  dct_title: Selective blockade of P/Q-type calcium channels by the metabotropic glutamate
    receptor type 7 involves a phospholipase C pathway in neurons@
  fabio_hasPubmedId: '11050109'
...