Cajal-Retzius cells in early postnatal mouse cortex selectively express functional metabotropic glutamate receptors Martínez, Galán López Bendito, Guillermina Luján, Rafael Shigemoto, Ryuichi ; https://orcid.org/0000-0001-8761-9444 Fairén, Alfonso Valdeolmillos, Miguel Glutamate receptors have been linked to the regulation of several developmental events in the CNS. By using cortical slices of early postnatal mice, we show that in layer I cells, glutamate produces intracellular calcium ([Ca2+]i) elevations mediated by ionotropic and metabotropic glutamate receptors (mGluRs). The contribution of mGluRs to these responses was demonstrated by application of tACPD, an agonist to groups I and II mGluRs, which evoked [Ca2+]i increases that could be reversibly blocked by MCPG, an antagonist to groups I and II mGluRs. In the absence of extracellular Ca2+, repetitive applications of tACPD or quisqualate, an agonist to group I mGluRs, elicited decreasing [Ca2+]i responses that were restored by refilling a thapsigargin-sensitive Ca2+ store. The use of specific group I mGluR agonists CHPG and DHPG indicated that the functional mGluR in layer I was of the mGluR1 subtype. Subtype specific antibodies confirmed the presence of mGlur1α, but not mGluR5, in Cajal-Retzius (Reelin-immunoreactive) neurons. Wiley-Blackwell 2001 info:eu-repo/semantics/article doc-type:article text http://purl.org/coar/resource_type/c_2df8fbb1 https://research-explorer.ista.ac.at/record/2606 Martínez G, López Bendito G, Luján R, Shigemoto R, Fairén A, Valdeolmillos M. Cajal-Retzius cells in early postnatal mouse cortex selectively express functional metabotropic glutamate receptors. <i>European Journal of Neuroscience</i>. 2001;13(6):1147-1154. doi:<a href="https://doi.org/10.1046/j.0953-816X.2001.01494.x">10.1046/j.0953-816X.2001.01494.x</a> eng info:eu-repo/semantics/altIdentifier/doi/10.1046/j.0953-816X.2001.01494.x info:eu-repo/semantics/altIdentifier/issn/0953-816X info:eu-repo/semantics/altIdentifier/pmid/11285012 info:eu-repo/semantics/closedAccess