---
_id: '2606'
abstract:
- lang: eng
  text: Glutamate receptors have been linked to the regulation of several developmental
    events in the CNS. By using cortical slices of early postnatal mice, we show that
    in layer I cells, glutamate produces intracellular calcium ([Ca2+]i) elevations
    mediated by ionotropic and metabotropic glutamate receptors (mGluRs). The contribution
    of mGluRs to these responses was demonstrated by application of tACPD, an agonist
    to groups I and II mGluRs, which evoked [Ca2+]i increases that could be reversibly
    blocked by MCPG, an antagonist to groups I and II mGluRs. In the absence of extracellular
    Ca2+, repetitive applications of tACPD or quisqualate, an agonist to group I mGluRs,
    elicited decreasing [Ca2+]i responses that were restored by refilling a thapsigargin-sensitive
    Ca2+ store. The use of specific group I mGluR agonists CHPG and DHPG indicated
    that the functional mGluR in layer I was of the mGluR1 subtype. Subtype specific
    antibodies confirmed the presence of mGlur1α, but not mGluR5, in Cajal-Retzius
    (Reelin-immunoreactive) neurons.
acknowledgement: MV  and  AF  are  senior  coauthors  of  this  work,  which  was  supported  by
  Ministerio de Educacion y Cultura, grants SAF97/0195 and SAF 2000-0152-C02-02 to
  M.V; PB94-0219-CO2-01 and PB97-0582-CO2-01 to A.F., Accio Especial  de  R+D  AE98-18  from  Generalitat  Valenciana,  and  a  Fellowship
  from Bancaixa-C.S.I.C. to J.R.M.-G. We wish to thank Andre M. Goffinet for his  G10  antireelin  antibody  and  Roberto  Gallego,  Juan  M.  Luque  and  Felix
  Viana for their constructive criticisms on previous versions of the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Galán
  full_name: Martínez, Galán
  last_name: Martínez
- first_name: Guillermina
  full_name: López Bendito, Guillermina
  last_name: López Bendito
- first_name: Rafael
  full_name: Luján, Rafael
  last_name: Luján
- first_name: Ryuichi
  full_name: Shigemoto, Ryuichi
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
- first_name: Alfonso
  full_name: Fairén, Alfonso
  last_name: Fairén
- first_name: Miguel
  full_name: Valdeolmillos, Miguel
  last_name: Valdeolmillos
citation:
  ama: Martínez G, López Bendito G, Luján R, Shigemoto R, Fairén A, Valdeolmillos
    M. Cajal-Retzius cells in early postnatal mouse cortex selectively express functional
    metabotropic glutamate receptors. <i>European Journal of Neuroscience</i>. 2001;13(6):1147-1154.
    doi:<a href="https://doi.org/10.1046/j.0953-816X.2001.01494.x">10.1046/j.0953-816X.2001.01494.x</a>
  apa: Martínez, G., López Bendito, G., Luján, R., Shigemoto, R., Fairén, A., &#38;
    Valdeolmillos, M. (2001). Cajal-Retzius cells in early postnatal mouse cortex
    selectively express functional metabotropic glutamate receptors. <i>European Journal
    of Neuroscience</i>. Wiley-Blackwell. <a href="https://doi.org/10.1046/j.0953-816X.2001.01494.x">https://doi.org/10.1046/j.0953-816X.2001.01494.x</a>
  chicago: Martínez, Galán, Guillermina López Bendito, Rafael Luján, Ryuichi Shigemoto,
    Alfonso Fairén, and Miguel Valdeolmillos. “Cajal-Retzius Cells in Early Postnatal
    Mouse Cortex Selectively Express Functional Metabotropic Glutamate Receptors.”
    <i>European Journal of Neuroscience</i>. Wiley-Blackwell, 2001. <a href="https://doi.org/10.1046/j.0953-816X.2001.01494.x">https://doi.org/10.1046/j.0953-816X.2001.01494.x</a>.
  ieee: G. Martínez, G. López Bendito, R. Luján, R. Shigemoto, A. Fairén, and M. Valdeolmillos,
    “Cajal-Retzius cells in early postnatal mouse cortex selectively express functional
    metabotropic glutamate receptors,” <i>European Journal of Neuroscience</i>, vol.
    13, no. 6. Wiley-Blackwell, pp. 1147–1154, 2001.
  ista: Martínez G, López Bendito G, Luján R, Shigemoto R, Fairén A, Valdeolmillos
    M. 2001. Cajal-Retzius cells in early postnatal mouse cortex selectively express
    functional metabotropic glutamate receptors. European Journal of Neuroscience.
    13(6), 1147–1154.
  mla: Martínez, Galán, et al. “Cajal-Retzius Cells in Early Postnatal Mouse Cortex
    Selectively Express Functional Metabotropic Glutamate Receptors.” <i>European
    Journal of Neuroscience</i>, vol. 13, no. 6, Wiley-Blackwell, 2001, pp. 1147–54,
    doi:<a href="https://doi.org/10.1046/j.0953-816X.2001.01494.x">10.1046/j.0953-816X.2001.01494.x</a>.
  short: G. Martínez, G. López Bendito, R. Luján, R. Shigemoto, A. Fairén, M. Valdeolmillos,
    European Journal of Neuroscience 13 (2001) 1147–1154.
date_created: 2018-12-11T11:58:38Z
date_published: 2001-03-01T00:00:00Z
date_updated: 2023-05-24T12:53:46Z
day: '01'
doi: 10.1046/j.0953-816X.2001.01494.x
extern: '1'
external_id:
  pmid:
  - '11285012'
intvolume: '        13'
issue: '6'
language:
- iso: eng
month: '03'
oa_version: None
page: 1147 - 1154
pmid: 1
publication: European Journal of Neuroscience
publication_identifier:
  issn:
  - 0953-816X
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4293'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cajal-Retzius cells in early postnatal mouse cortex selectively express functional
  metabotropic glutamate receptors
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 13
year: '2001'
...