---
res:
  bibo_abstract:
  - An ion channel's function depends largely on its location and density on neurons.
    Here we used high-resolution immunolocalization to determine the subcellular distribution
    of the hyperpolarization-activated and cyclic-nucleotide-gated channel subunit
    1 (HCN1) in rat brain. Light microscopy revealed graded HCN1 immunoreactivity
    in apical dendrites of hippocampal, subicular and neocortical layer-5 pyramidal
    cells. Quantitative comparison of immunogold densities showed a 60-fold increase
    from somatic to distal apical dendritic membranes. Distal dendritic shafts had
    16 times more HCN1 labeling than proximal dendrites of similar diameters. At the
    same distance from the soma, the density of HCN1 was significantly higher in dendritic
    shafts than in spines. Our results reveal the complex cell surface distribution
    of voltage-gated ion-channels, and predict its role in increasing the computational
    power of single neurons via subcellular domain and input-specific mechanisms.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Andrea
      foaf_name: Lörincz, Andrea
      foaf_surname: Lörincz
  - foaf_Person:
      foaf_givenName: Takuya
      foaf_name: Notomi, Takuya
      foaf_surname: Notomi
  - foaf_Person:
      foaf_givenName: Gábor
      foaf_name: Tamás, Gábor
      foaf_surname: Tamás
  - foaf_Person:
      foaf_givenName: Ryuichi
      foaf_name: Shigemoto, Ryuichi
      foaf_surname: Shigemoto
      foaf_workInfoHomepage: http://www.librecat.org/personId=499F3ABC-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-8761-9444
  - foaf_Person:
      foaf_givenName: Zoltán
      foaf_name: Nusser, Zoltán
      foaf_surname: Nusser
  bibo_doi: 10.1038/nn962
  bibo_issue: '11'
  bibo_volume: 5
  dct_date: 2002^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/1097-6256
  dct_language: eng
  dct_publisher: Nature Publishing Group@
  dct_title: Polarized and compartment-dependent distribution of HCN1 in pyramidal
    cell dendrites@
  fabio_hasPubmedId: '12389030'
...