{"status":"public","article_processing_charge":"No","author":[{"first_name":"Andrea","last_name":"Lörincz","full_name":"Lörincz, Andrea"},{"first_name":"Takuya","full_name":"Notomi, Takuya","last_name":"Notomi"},{"first_name":"Gábor","full_name":"Tamás, Gábor","last_name":"Tamás"},{"first_name":"Ryuichi","last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444"},{"first_name":"Zoltán","last_name":"Nusser","full_name":"Nusser, Zoltán"}],"year":"2002","type":"journal_article","citation":{"ista":"Lörincz A, Notomi T, Tamás G, Shigemoto R, Nusser Z. 2002. Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites. Nature Neuroscience. 5(11), 1185–1193.","chicago":"Lörincz, Andrea, Takuya Notomi, Gábor Tamás, Ryuichi Shigemoto, and Zoltán Nusser. “Polarized and Compartment-Dependent Distribution of HCN1 in Pyramidal Cell Dendrites.” <i>Nature Neuroscience</i>. Nature Publishing Group, 2002. <a href=\"https://doi.org/10.1038/nn962\">https://doi.org/10.1038/nn962</a>.","short":"A. Lörincz, T. Notomi, G. Tamás, R. Shigemoto, Z. Nusser, Nature Neuroscience 5 (2002) 1185–1193.","apa":"Lörincz, A., Notomi, T., Tamás, G., Shigemoto, R., &#38; Nusser, Z. (2002). Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites. <i>Nature Neuroscience</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/nn962\">https://doi.org/10.1038/nn962</a>","ieee":"A. Lörincz, T. Notomi, G. Tamás, R. Shigemoto, and Z. Nusser, “Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites,” <i>Nature Neuroscience</i>, vol. 5, no. 11. Nature Publishing Group, pp. 1185–1193, 2002.","ama":"Lörincz A, Notomi T, Tamás G, Shigemoto R, Nusser Z. Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites. <i>Nature Neuroscience</i>. 2002;5(11):1185-1193. doi:<a href=\"https://doi.org/10.1038/nn962\">10.1038/nn962</a>","mla":"Lörincz, Andrea, et al. “Polarized and Compartment-Dependent Distribution of HCN1 in Pyramidal Cell Dendrites.” <i>Nature Neuroscience</i>, vol. 5, no. 11, Nature Publishing Group, 2002, pp. 1185–93, doi:<a href=\"https://doi.org/10.1038/nn962\">10.1038/nn962</a>."},"extern":"1","date_created":"2018-12-11T11:58:43Z","publist_id":"4278","intvolume":"         5","acknowledgement":"Z.N. received grants from the Hungarian Science Foundation (T032309), the Howard Hughes Medical Institute, the James S. McDonnell Foundation, the Wellcome Trust and the Boehringer Ingelheim Fund. Z.N. and R.S. received grants from CREST—Japan Science and Technology Corporation. G.T. is funded by the Wellcome Trust.","scopus_import":"1","date_updated":"2023-07-25T09:02:48Z","publisher":"Nature Publishing Group","oa_version":"None","volume":5,"day":"01","publication_status":"published","month":"11","abstract":[{"lang":"eng","text":"An ion channel's function depends largely on its location and density on neurons. Here we used high-resolution immunolocalization to determine the subcellular distribution of the hyperpolarization-activated and cyclic-nucleotide-gated channel subunit 1 (HCN1) in rat brain. Light microscopy revealed graded HCN1 immunoreactivity in apical dendrites of hippocampal, subicular and neocortical layer-5 pyramidal cells. Quantitative comparison of immunogold densities showed a 60-fold increase from somatic to distal apical dendritic membranes. Distal dendritic shafts had 16 times more HCN1 labeling than proximal dendrites of similar diameters. At the same distance from the soma, the density of HCN1 was significantly higher in dendritic shafts than in spines. Our results reveal the complex cell surface distribution of voltage-gated ion-channels, and predict its role in increasing the computational power of single neurons via subcellular domain and input-specific mechanisms."}],"date_published":"2002-11-01T00:00:00Z","page":"1185 - 1193","language":[{"iso":"eng"}],"publication_identifier":{"issn":["1097-6256"]},"_id":"2620","pmid":1,"doi":"10.1038/nn962","publication":"Nature Neuroscience","quality_controlled":"1","external_id":{"pmid":["12389030"]},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","title":"Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites","issue":"11","article_type":"original"}