---
_id: '2629'
abstract:
- lang: eng
text: The release of neurotransmitters is modulated by presynaptic metabotropic
glutamate receptors (mGluRs), which show a highly selective expression and subcellular
location in glutamatergic terminals in the hippocampus. Using immunocytochemistry,
we investigated whether one of the receptors, mGluR7, whose level of expression
is governed by the postsynaptic target, was present in GABAergic terminals and
whether such terminals targeted particular cells. A total of 165 interneuron dendritic
profiles receiving 466 synapses (82% mGluR7a-positive) were analysed. The presynaptic
active zones of most GAD-(77%) or GABA-positive (94%) synaptic boutons on interneurons
innervated by mGluR7a-enriched glutamatergic terminals (mGluR7a-decorated) were
immunopositive for mGluR7a. GABAergic terminals on pyramidal cells and most other
interneurons in str. oriens were mGluR7a-immunonegative. The mGluR7a-decorated
cells were mostly somatostatin- and mGluR1α-immunopositive neurons in str. oriens
and the alveus. Their GABAergic input mainly originated from VIP-positive terminals,
90% of which expressed high levels of mGluR7a in the presynaptic active zone.
Parvalbumin-positive synaptic terminals were rare on mGluR7a-decorated cells,
but on these neurons 73% of them were mGluR7a-immunopositive. Some type II synapses
innervating interneurons were immunopositive for mGluR7b, as were some type I
synapses. Because not all target cells of VIP-positive neurons are known it has
not been possible to determine whether mGluR7 is expressed in a target-cell-specific
manner in the terminals of single GABAergic cells. The activation of mGluR7 may
decrease GABA release to mGluR7-decorated cells at times of high pyramidal cell
activity, which elevates extracellular glutamate levels. Alternatively, the presynaptic
receptor may be activated by as yet unidentified endogenous ligands released by
the GABAergic terminals or the postsynaptic dendrites.
author:
- first_name: Péter
full_name: Somogyi, Péter
last_name: Somogyi
- first_name: Yannis
full_name: Dalezios, Yannis
last_name: Dalezios
- first_name: Rafael
full_name: Luján, Rafael
last_name: Luján
- first_name: John
full_name: Roberts, John D
last_name: Roberts
- first_name: Masahiko
full_name: Watanabe, Masahiko
last_name: Watanabe
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
citation:
ama: Somogyi P, Dalezios Y, Luján R, Roberts J, Watanabe M, Shigemoto R. High level
of mGluR7 in the presynaptic active zones of select populations of GABAergic terminals
innervating interneurons in the rat hippocampus. European Journal of Neuroscience.
2003;17(12):2503-2520. doi:10.1046/j.1460-9568.2003.02697.x
apa: Somogyi, P., Dalezios, Y., Luján, R., Roberts, J., Watanabe, M., & Shigemoto,
R. (2003). High level of mGluR7 in the presynaptic active zones of select populations
of GABAergic terminals innervating interneurons in the rat hippocampus. European
Journal of Neuroscience. Wiley-Blackwell. https://doi.org/10.1046/j.1460-9568.2003.02697.x
chicago: Somogyi, Péter, Yannis Dalezios, Rafael Luján, John Roberts, Masahiko Watanabe,
and Ryuichi Shigemoto. “High Level of MGluR7 in the Presynaptic Active Zones of
Select Populations of GABAergic Terminals Innervating Interneurons in the Rat
Hippocampus.” European Journal of Neuroscience. Wiley-Blackwell, 2003.
https://doi.org/10.1046/j.1460-9568.2003.02697.x.
ieee: P. Somogyi, Y. Dalezios, R. Luján, J. Roberts, M. Watanabe, and R. Shigemoto,
“High level of mGluR7 in the presynaptic active zones of select populations of
GABAergic terminals innervating interneurons in the rat hippocampus,” European
Journal of Neuroscience, vol. 17, no. 12. Wiley-Blackwell, pp. 2503–2520,
2003.
ista: Somogyi P, Dalezios Y, Luján R, Roberts J, Watanabe M, Shigemoto R. 2003.
High level of mGluR7 in the presynaptic active zones of select populations of
GABAergic terminals innervating interneurons in the rat hippocampus. European
Journal of Neuroscience. 17(12), 2503–2520.
mla: Somogyi, Péter, et al. “High Level of MGluR7 in the Presynaptic Active Zones
of Select Populations of GABAergic Terminals Innervating Interneurons in the Rat
Hippocampus.” European Journal of Neuroscience, vol. 17, no. 12, Wiley-Blackwell,
2003, pp. 2503–20, doi:10.1046/j.1460-9568.2003.02697.x.
short: P. Somogyi, Y. Dalezios, R. Luján, J. Roberts, M. Watanabe, R. Shigemoto,
European Journal of Neuroscience 17 (2003) 2503–2520.
date_created: 2018-12-11T11:58:46Z
date_published: 2003-06-01T00:00:00Z
date_updated: 2021-01-12T06:58:41Z
day: '01'
doi: 10.1046/j.1460-9568.2003.02697.x
extern: 1
intvolume: ' 17'
issue: '12'
month: '06'
page: 2503 - 2520
publication: European Journal of Neuroscience
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4269'
quality_controlled: 0
status: public
title: High level of mGluR7 in the presynaptic active zones of select populations
of GABAergic terminals innervating interneurons in the rat hippocampus
type: journal_article
volume: 17
year: '2003'
...