---
_id: '2645'
abstract:
- lang: eng
  text: 'The globus pallidus (GP) is a critical component of the basal ganglia circuitry
    controlling motor behavior. Dysregulation of GP activity has been implicated in
    a number of psychomotor disorders, including Parkinson''s disease (PD), in which
    a cardinal feature of the pathophysiology is an alteration in the pattern and
    synchrony of discharge in GP neurons. Yet the determinants of this activity in
    GP neurons are poorly understood. To help fill this gap, electrophysiological,
    molecular, and computational approaches were used to identify and characterize
    GABAergic GP neurons in tissue slices from rodents. In vitro, GABAergic GP neurons
    generate a regular, autonomous, single-spike pacemaker activity. Hyperpolarization-activated,
    cyclic nucleotide-gated cation (HCN) channels make an important contribution to
    this process: their blockade with ZD7288 significantly slowed discharge rate and
    decreased its regularity. HCN currents evoked by somatic voltage clamp had fast
    and slow components. Single-cell RT-PCR and immunohistochemical approaches revealed
    robust expression of HCN2 subunits as well as significant levels of HCN1 subunits
    in GABAergic GP neurons. Transient activation of striatal GABAergic input to GP
    neurons led to a resetting of rhythmic discharge that was dependent on HCN currents.
    Simulations suggested that the ability of transient striatal GABAergic input to
    reset pacemaking was dependent on dendritic HCN2/HCN1 channels. Together, these
    studies show that HCN channels in GABAergic GP neurons are key determinants of
    the regularity and rate of pacemaking as well as striatal resetting of this activity,
    implicating HCN channels in the emergence of synchrony in PD.'
author:
- first_name: Savio
  full_name: Chan, Savio
  last_name: Chan
- first_name: Ryuichi
  full_name: Ryuichi Shigemoto
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
- first_name: Jeff
  full_name: Mercer, Jeff N
  last_name: Mercer
- first_name: James
  full_name: Surmeier, James D
  last_name: Surmeier
citation:
  ama: Chan S, Shigemoto R, Mercer J, Surmeier J. HCN2 and HCN1 channels govern the
    regularity of autonomous pacemaking and synaptic resetting in globus pallidus
    neurons. <i>Journal of Neuroscience</i>. 2004;24(44):9921-9932. doi:<a href="https://doi.org/10.1523/JNEUROSCI.2162-04.2004">10.1523/JNEUROSCI.2162-04.2004</a>
  apa: Chan, S., Shigemoto, R., Mercer, J., &#38; Surmeier, J. (2004). HCN2 and HCN1
    channels govern the regularity of autonomous pacemaking and synaptic resetting
    in globus pallidus neurons. <i>Journal of Neuroscience</i>. Society for Neuroscience.
    <a href="https://doi.org/10.1523/JNEUROSCI.2162-04.2004">https://doi.org/10.1523/JNEUROSCI.2162-04.2004</a>
  chicago: Chan, Savio, Ryuichi Shigemoto, Jeff Mercer, and James Surmeier. “HCN2
    and HCN1 Channels Govern the Regularity of Autonomous Pacemaking and Synaptic
    Resetting in Globus Pallidus Neurons.” <i>Journal of Neuroscience</i>. Society
    for Neuroscience, 2004. <a href="https://doi.org/10.1523/JNEUROSCI.2162-04.2004">https://doi.org/10.1523/JNEUROSCI.2162-04.2004</a>.
  ieee: S. Chan, R. Shigemoto, J. Mercer, and J. Surmeier, “HCN2 and HCN1 channels
    govern the regularity of autonomous pacemaking and synaptic resetting in globus
    pallidus neurons,” <i>Journal of Neuroscience</i>, vol. 24, no. 44. Society for
    Neuroscience, pp. 9921–9932, 2004.
  ista: Chan S, Shigemoto R, Mercer J, Surmeier J. 2004. HCN2 and HCN1 channels govern
    the regularity of autonomous pacemaking and synaptic resetting in globus pallidus
    neurons. Journal of Neuroscience. 24(44), 9921–9932.
  mla: Chan, Savio, et al. “HCN2 and HCN1 Channels Govern the Regularity of Autonomous
    Pacemaking and Synaptic Resetting in Globus Pallidus Neurons.” <i>Journal of Neuroscience</i>,
    vol. 24, no. 44, Society for Neuroscience, 2004, pp. 9921–32, doi:<a href="https://doi.org/10.1523/JNEUROSCI.2162-04.2004">10.1523/JNEUROSCI.2162-04.2004</a>.
  short: S. Chan, R. Shigemoto, J. Mercer, J. Surmeier, Journal of Neuroscience 24
    (2004) 9921–9932.
date_created: 2018-12-11T11:58:51Z
date_published: 2004-11-03T00:00:00Z
date_updated: 2021-01-12T06:58:47Z
day: '03'
doi: 10.1523/JNEUROSCI.2162-04.2004
extern: 1
intvolume: '        24'
issue: '44'
month: '11'
page: 9921 - 9932
publication: Journal of Neuroscience
publication_status: published
publisher: Society for Neuroscience
publist_id: '4252'
quality_controlled: 0
status: public
title: HCN2 and HCN1 channels govern the regularity of autonomous pacemaking and synaptic
  resetting in globus pallidus neurons
type: journal_article
volume: 24
year: '2004'
...