{"author":[{"full_name":"Inamura, Mihoko","first_name":"Mihoko","last_name":"Inamura"},{"full_name":"Itakura, Makoto","last_name":"Itakura","first_name":"Makoto"},{"full_name":"Okamoto, Hirotsugu","first_name":"Hirotsugu","last_name":"Okamoto"},{"last_name":"Hoka","first_name":"Sumio","full_name":"Hoka, Sumio"},{"full_name":"Mizoguchi, Akira","last_name":"Mizoguchi","first_name":"Akira"},{"last_name":"Fukazawa","first_name":"Yugo","full_name":"Fukazawa, Yugo"},{"full_name":"Ryuichi Shigemoto","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi"},{"full_name":"Yamamori, Saori","first_name":"Saori","last_name":"Yamamori"},{"first_name":"Masami","last_name":"Takahashi","full_name":"Takahashi, Masami"}],"date_created":"2018-12-11T11:58:55Z","date_updated":"2021-01-12T06:58:52Z","title":" Differential localization and regulation of stargazin-like protein, γ-8 and stargazin in the plasma membrane of hippocampal and cortical neurons","page":"45 - 53","issue":"1","year":"2006","day":"01","_id":"2659","doi":"10.1016/j.neures.2006.01.004","quality_controlled":0,"intvolume":"        55","type":"journal_article","publist_id":"4238","publication_status":"published","extern":1,"volume":55,"publication":"Neuroscience Research","month":"05","citation":{"ama":"Inamura M, Itakura M, Okamoto H, et al.  Differential localization and regulation of stargazin-like protein, γ-8 and stargazin in the plasma membrane of hippocampal and cortical neurons. <i>Neuroscience Research</i>. 2006;55(1):45-53. doi:<a href=\"https://doi.org/10.1016/j.neures.2006.01.004\">10.1016/j.neures.2006.01.004</a>","chicago":"Inamura, Mihoko, Makoto Itakura, Hirotsugu Okamoto, Sumio Hoka, Akira Mizoguchi, Yugo Fukazawa, Ryuichi Shigemoto, Saori Yamamori, and Masami Takahashi. “ Differential Localization and Regulation of Stargazin-like Protein, γ-8 and Stargazin in the Plasma Membrane of Hippocampal and Cortical Neurons.” <i>Neuroscience Research</i>. Elsevier, 2006. <a href=\"https://doi.org/10.1016/j.neures.2006.01.004\">https://doi.org/10.1016/j.neures.2006.01.004</a>.","apa":"Inamura, M., Itakura, M., Okamoto, H., Hoka, S., Mizoguchi, A., Fukazawa, Y., … Takahashi, M. (2006).  Differential localization and regulation of stargazin-like protein, γ-8 and stargazin in the plasma membrane of hippocampal and cortical neurons. <i>Neuroscience Research</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neures.2006.01.004\">https://doi.org/10.1016/j.neures.2006.01.004</a>","ieee":"M. Inamura <i>et al.</i>, “ Differential localization and regulation of stargazin-like protein, γ-8 and stargazin in the plasma membrane of hippocampal and cortical neurons,” <i>Neuroscience Research</i>, vol. 55, no. 1. Elsevier, pp. 45–53, 2006.","short":"M. Inamura, M. Itakura, H. Okamoto, S. Hoka, A. Mizoguchi, Y. Fukazawa, R. Shigemoto, S. Yamamori, M. Takahashi, Neuroscience Research 55 (2006) 45–53.","ista":"Inamura M, Itakura M, Okamoto H, Hoka S, Mizoguchi A, Fukazawa Y, Shigemoto R, Yamamori S, Takahashi M. 2006.  Differential localization and regulation of stargazin-like protein, γ-8 and stargazin in the plasma membrane of hippocampal and cortical neurons. Neuroscience Research. 55(1), 45–53.","mla":"Inamura, Mihoko, et al. “ Differential Localization and Regulation of Stargazin-like Protein, γ-8 and Stargazin in the Plasma Membrane of Hippocampal and Cortical Neurons.” <i>Neuroscience Research</i>, vol. 55, no. 1, Elsevier, 2006, pp. 45–53, doi:<a href=\"https://doi.org/10.1016/j.neures.2006.01.004\">10.1016/j.neures.2006.01.004</a>."},"publisher":"Elsevier","status":"public","abstract":[{"text":"Transmembrane AMPA receptor regulatory proteins (TARPs), including stargazin/γ-2, are associated with AMPA receptors and participate in their surface delivery and anchoring at the postsynaptic membrane. TARPs may also act as a positive modulator of the AMPA receptor ion channel function; however, little is known about other TARP members except for stargazin/γ-2. We examined the synaptic localization of stargazin/γ-2 and γ-8 by immunoelectron microscopy and biochemical analysis. The analysis of sodium dodecyl sulfate-digested freeze-fracture replica labeling revealed that stargazin/γ-2 was concentrated in the postsynaptic area, whereas γ-8 was distributed both in synaptic and extra-synaptic plasma membranes of the hippocampal neuron. When a synaptic plasma membrane-enriched brain fraction was treated with Triton X-100 and separated by sucrose density gradient ultracentrifugation, a large proportion of NMDA receptor and stargazin/γ-2 was accumulated in raft-enriched fractions, whereas AMPA receptor and γ-8 were distributed in both the raft-enriched fractions and other Triton-insoluble fractions. Phosphorylation of stargazin/γ-2 and γ-8 was regulated by different sets of kinases and phosphatases in cultured cortical neurons. These results suggested that stargazin/γ-2 and γ-8 have distinct roles in postsynaptic membranes under the regulation of different intracellular signaling pathways.","lang":"eng"}],"date_published":"2006-05-01T00:00:00Z"}