{"date_updated":"2021-01-12T06:58:53Z","quality_controlled":0,"abstract":[{"lang":"eng","text":"Pavlovian fear conditioning, a simple form of associative learning, is thought to involve the induction of associative, NMDA receptor-dependent long-term potentiation (LTP) in the lateral amygdala. Using a combined genetic and electrophysiological approach, we show here that lack of a specific GABAB receptor subtype, GABAB(1a,2), unmasks a nonassociative, NMDA receptor-independent form of presynaptic LTP at cortico-amygdala afferents. Moreover, the level of presynaptic GABA B(1a,2) receptor activation, and hence the balance between associative and nonassociative forms of LTP, can be dynamically modulated by local inhibitory activity. At the behavioral level, genetic loss of GABA B(1a) results in a generalization of conditioned fear to nonconditioned stimuli. Our findings indicate that presynaptic inhibition through GABAB(1a,2) receptors serves as an activity-dependent constraint on the induction of homosynaptic plasticity, which may be important to prevent the generalization of conditioned fear."}],"_id":"2660","publication":"Nature Neuroscience","issue":"8","doi":"10.1038/nn1732","publist_id":"4236","author":[{"first_name":"Hamdy","full_name":"Shaban, Hamdy","last_name":"Shaban"},{"full_name":"Humeau, Yann","last_name":"Humeau","first_name":"Yann"},{"last_name":"Herry","full_name":"Herry, Cyril","first_name":"Cyril"},{"first_name":"Guillaume","last_name":"Cassasus","full_name":"Cassasus, Guillaume"},{"first_name":"Ryuichi","orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Ryuichi Shigemoto","last_name":"Shigemoto"},{"first_name":"Stéphane","last_name":"Ciocchi","full_name":"Ciocchi, Stéphane"},{"last_name":"Barbieri","full_name":"Barbieri, Samuel","first_name":"Samuel"},{"first_name":"Herman","full_name":"Van Der Putten, Herman V","last_name":"Van Der Putten"},{"full_name":"Kaupmann, Klemens","last_name":"Kaupmann","first_name":"Klemens"},{"first_name":"Bernhard","last_name":"Bettler","full_name":"Bettler, Bernhard"},{"last_name":"Lüthi","full_name":"Lüthi, Andreas","first_name":"Andreas"}],"citation":{"ieee":"H. Shaban <i>et al.</i>, “Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition,” <i>Nature Neuroscience</i>, vol. 9, no. 8. Nature Publishing Group, pp. 1028–1035, 2006.","mla":"Shaban, Hamdy, et al. “Generalization of Amygdala LTP and Conditioned Fear in the Absence of Presynaptic Inhibition.” <i>Nature Neuroscience</i>, vol. 9, no. 8, Nature Publishing Group, 2006, pp. 1028–35, doi:<a href=\"https://doi.org/10.1038/nn1732\">10.1038/nn1732</a>.","apa":"Shaban, H., Humeau, Y., Herry, C., Cassasus, G., Shigemoto, R., Ciocchi, S., … Lüthi, A. (2006). Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition. <i>Nature Neuroscience</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/nn1732\">https://doi.org/10.1038/nn1732</a>","chicago":"Shaban, Hamdy, Yann Humeau, Cyril Herry, Guillaume Cassasus, Ryuichi Shigemoto, Stéphane Ciocchi, Samuel Barbieri, et al. “Generalization of Amygdala LTP and Conditioned Fear in the Absence of Presynaptic Inhibition.” <i>Nature Neuroscience</i>. Nature Publishing Group, 2006. <a href=\"https://doi.org/10.1038/nn1732\">https://doi.org/10.1038/nn1732</a>.","short":"H. Shaban, Y. Humeau, C. Herry, G. Cassasus, R. Shigemoto, S. Ciocchi, S. Barbieri, H. Van Der Putten, K. Kaupmann, B. Bettler, A. Lüthi, Nature Neuroscience 9 (2006) 1028–1035.","ama":"Shaban H, Humeau Y, Herry C, et al. Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition. <i>Nature Neuroscience</i>. 2006;9(8):1028-1035. doi:<a href=\"https://doi.org/10.1038/nn1732\">10.1038/nn1732</a>","ista":"Shaban H, Humeau Y, Herry C, Cassasus G, Shigemoto R, Ciocchi S, Barbieri S, Van Der Putten H, Kaupmann K, Bettler B, Lüthi A. 2006. Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition. Nature Neuroscience. 9(8), 1028–1035."},"intvolume":"         9","page":"1028 - 1035","status":"public","extern":1,"publication_status":"published","title":"Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition","volume":9,"type":"journal_article","year":"2006","publisher":"Nature Publishing Group","day":"01","month":"08","date_created":"2018-12-11T11:58:55Z","date_published":"2006-08-01T00:00:00Z"}