--- _id: '2681' abstract: - lang: eng text: Left-right asymmetry of the brain has been studied mostly through psychological examination and functional imaging in primates, leaving its molecular and synaptic aspects largely unaddressed. Here, we show that hippocampal CA1 pyramidal cell synapses differ in size, shape, and glutamate receptor expression depending on the laterality of presynaptic origin. CA1 synapses receiving neuronal input from the right CA3 pyramidal cells are larger and have more perforated PSD and a GluR1 expression level twice as high as those receiving input from the left CA3. The synaptic density of GluR1 increases as the size of a synapse increases, whereas that of NR2B decreases because of the relatively constant NR2B expression in CA1 regardless of synapse size. Densities of other major glutamate receptor subunits show no correlation with synapse size, thus resulting in higher net expression in synapses having right input. Our study demonstrates universal left-right asymmetry of hippocampal synapses with a fundamental relationship between synaptic area and the expression of glutamate receptor subunits. author: - first_name: Yoshiaki full_name: Shinohara, Yoshiaki last_name: Shinohara - first_name: Hajime full_name: Hirase, Hajime last_name: Hirase - first_name: Masahiko full_name: Watanabe, Masahiko last_name: Watanabe - first_name: Makoto full_name: Itakura, Makoto last_name: Itakura - first_name: Masami full_name: Takahashi, Masami last_name: Takahashi - first_name: Ryuichi full_name: Ryuichi Shigemoto id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 citation: ama: Shinohara Y, Hirase H, Watanabe M, Itakura M, Takahashi M, Shigemoto R. Left-right asymmetry of the hippocampal synapses with differential subunit allocation of glutamate receptors. PNAS. 2008;105(49):19498-19503. doi:10.1073/pnas.0807461105 apa: Shinohara, Y., Hirase, H., Watanabe, M., Itakura, M., Takahashi, M., & Shigemoto, R. (2008). Left-right asymmetry of the hippocampal synapses with differential subunit allocation of glutamate receptors. PNAS. National Academy of Sciences. https://doi.org/10.1073/pnas.0807461105 chicago: Shinohara, Yoshiaki, Hajime Hirase, Masahiko Watanabe, Makoto Itakura, Masami Takahashi, and Ryuichi Shigemoto. “Left-Right Asymmetry of the Hippocampal Synapses with Differential Subunit Allocation of Glutamate Receptors.” PNAS. National Academy of Sciences, 2008. https://doi.org/10.1073/pnas.0807461105. ieee: Y. Shinohara, H. Hirase, M. Watanabe, M. Itakura, M. Takahashi, and R. Shigemoto, “Left-right asymmetry of the hippocampal synapses with differential subunit allocation of glutamate receptors,” PNAS, vol. 105, no. 49. National Academy of Sciences, pp. 19498–19503, 2008. ista: Shinohara Y, Hirase H, Watanabe M, Itakura M, Takahashi M, Shigemoto R. 2008. Left-right asymmetry of the hippocampal synapses with differential subunit allocation of glutamate receptors. PNAS. 105(49), 19498–19503. mla: Shinohara, Yoshiaki, et al. “Left-Right Asymmetry of the Hippocampal Synapses with Differential Subunit Allocation of Glutamate Receptors.” PNAS, vol. 105, no. 49, National Academy of Sciences, 2008, pp. 19498–503, doi:10.1073/pnas.0807461105. short: Y. Shinohara, H. Hirase, M. Watanabe, M. Itakura, M. Takahashi, R. Shigemoto, PNAS 105 (2008) 19498–19503. date_created: 2018-12-11T11:59:02Z date_published: 2008-12-09T00:00:00Z date_updated: 2021-01-12T06:59:01Z day: '09' doi: 10.1073/pnas.0807461105 extern: 1 intvolume: ' 105' issue: '49' month: '12' page: 19498 - 19503 publication: PNAS publication_status: published publisher: National Academy of Sciences publist_id: '4217' quality_controlled: 0 status: public title: Left-right asymmetry of the hippocampal synapses with differential subunit allocation of glutamate receptors type: journal_article volume: 105 year: '2008' ...