---
_id: '2681'
abstract:
- lang: eng
text: Left-right asymmetry of the brain has been studied mostly through psychological
examination and functional imaging in primates, leaving its molecular and synaptic
aspects largely unaddressed. Here, we show that hippocampal CA1 pyramidal cell
synapses differ in size, shape, and glutamate receptor expression depending on
the laterality of presynaptic origin. CA1 synapses receiving neuronal input from
the right CA3 pyramidal cells are larger and have more perforated PSD and a GluR1
expression level twice as high as those receiving input from the left CA3. The
synaptic density of GluR1 increases as the size of a synapse increases, whereas
that of NR2B decreases because of the relatively constant NR2B expression in CA1
regardless of synapse size. Densities of other major glutamate receptor subunits
show no correlation with synapse size, thus resulting in higher net expression
in synapses having right input. Our study demonstrates universal left-right asymmetry
of hippocampal synapses with a fundamental relationship between synaptic area
and the expression of glutamate receptor subunits.
author:
- first_name: Yoshiaki
full_name: Shinohara, Yoshiaki
last_name: Shinohara
- first_name: Hajime
full_name: Hirase, Hajime
last_name: Hirase
- first_name: Masahiko
full_name: Watanabe, Masahiko
last_name: Watanabe
- first_name: Makoto
full_name: Itakura, Makoto
last_name: Itakura
- first_name: Masami
full_name: Takahashi, Masami
last_name: Takahashi
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
citation:
ama: Shinohara Y, Hirase H, Watanabe M, Itakura M, Takahashi M, Shigemoto R. Left-right
asymmetry of the hippocampal synapses with differential subunit allocation of
glutamate receptors. PNAS. 2008;105(49):19498-19503. doi:10.1073/pnas.0807461105
apa: Shinohara, Y., Hirase, H., Watanabe, M., Itakura, M., Takahashi, M., &
Shigemoto, R. (2008). Left-right asymmetry of the hippocampal synapses with differential
subunit allocation of glutamate receptors. PNAS. National Academy of Sciences.
https://doi.org/10.1073/pnas.0807461105
chicago: Shinohara, Yoshiaki, Hajime Hirase, Masahiko Watanabe, Makoto Itakura,
Masami Takahashi, and Ryuichi Shigemoto. “Left-Right Asymmetry of the Hippocampal
Synapses with Differential Subunit Allocation of Glutamate Receptors.” PNAS.
National Academy of Sciences, 2008. https://doi.org/10.1073/pnas.0807461105.
ieee: Y. Shinohara, H. Hirase, M. Watanabe, M. Itakura, M. Takahashi, and R. Shigemoto,
“Left-right asymmetry of the hippocampal synapses with differential subunit allocation
of glutamate receptors,” PNAS, vol. 105, no. 49. National Academy of Sciences,
pp. 19498–19503, 2008.
ista: Shinohara Y, Hirase H, Watanabe M, Itakura M, Takahashi M, Shigemoto R. 2008.
Left-right asymmetry of the hippocampal synapses with differential subunit allocation
of glutamate receptors. PNAS. 105(49), 19498–19503.
mla: Shinohara, Yoshiaki, et al. “Left-Right Asymmetry of the Hippocampal Synapses
with Differential Subunit Allocation of Glutamate Receptors.” PNAS, vol.
105, no. 49, National Academy of Sciences, 2008, pp. 19498–503, doi:10.1073/pnas.0807461105.
short: Y. Shinohara, H. Hirase, M. Watanabe, M. Itakura, M. Takahashi, R. Shigemoto,
PNAS 105 (2008) 19498–19503.
date_created: 2018-12-11T11:59:02Z
date_published: 2008-12-09T00:00:00Z
date_updated: 2021-01-12T06:59:01Z
day: '09'
doi: 10.1073/pnas.0807461105
extern: 1
intvolume: ' 105'
issue: '49'
month: '12'
page: 19498 - 19503
publication: PNAS
publication_status: published
publisher: National Academy of Sciences
publist_id: '4217'
quality_controlled: 0
status: public
title: Left-right asymmetry of the hippocampal synapses with differential subunit
allocation of glutamate receptors
type: journal_article
volume: 105
year: '2008'
...