--- res: bibo_abstract: - Conduction velocity (CV) of myelinated axons has been shown to be regulated by oligodendrocytes even after myelination has been completed. However, how myelinating oligodendrocytes regulate CV, and what the significance of this regulation is for normal brain function remain unknown. To address these questions, we analyzed a transgenic mouse line harboring extra copies of the myelin proteolipid protein 1 (plp1) gene (plp1tg/- mice) at 2 months of age. At this stage, the plp1tg/- mice have an unaffected myelin structure with a normally appearing ion channel distribution, but the CV in all axonal tracts tested in the CNS is greatly reduced. We also found decreased axonal diameters and slightly abnormal paranodal structures, both of which can be a cause for the reduced CV. Interestingly the plp1tg/- mice showed altered anxiety-like behaviors, reduced prepulse inhibitions, spatial learning deficits and working memory deficit, all of which are schizophrenia-related behaviors. Our results implicate that abnormalities in the neuron-glia interactions at the paranodal junctions can result in reduced CV in the CNS, which then induces behavioral abnormalities related to schizophrenia.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Hisataka foaf_name: Tanaka, Hisataka foaf_surname: Tanaka - foaf_Person: foaf_givenName: Jianmei foaf_name: Ma, Jianmei foaf_surname: Ma - foaf_Person: foaf_givenName: Kenji foaf_name: Tanaka, Kenji F foaf_surname: Tanaka - foaf_Person: foaf_givenName: Keizo foaf_name: Takao, Keizo foaf_surname: Takao - foaf_Person: foaf_givenName: Munekazu foaf_name: Komada, Munekazu foaf_surname: Komada - foaf_Person: foaf_givenName: Koichi foaf_name: Tanda, Koichi foaf_surname: Tanda - foaf_Person: foaf_givenName: Ayaka foaf_name: Suzuki, Ayaka foaf_surname: Suzuki - foaf_Person: foaf_givenName: Tomoko foaf_name: Ishibashi, Tomoko foaf_surname: Ishibashi - foaf_Person: foaf_givenName: Hiroko foaf_name: Baba, Hiroko foaf_surname: Baba - foaf_Person: foaf_givenName: Tadashi foaf_name: Isa, Tadashi foaf_surname: Isa - foaf_Person: foaf_givenName: Ryuichi foaf_name: Ryuichi Shigemoto foaf_surname: Shigemoto foaf_workInfoHomepage: http://www.librecat.org/personId=499F3ABC-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0001-8761-9444 - foaf_Person: foaf_givenName: Katsuhiko foaf_name: Ono, Katsuhiko foaf_surname: Ono - foaf_Person: foaf_givenName: Tsuyoshi foaf_name: Miyakawa, Tsuyoshi foaf_surname: Miyakawa - foaf_Person: foaf_givenName: Kazuhiro foaf_name: Ikenaka, Kazuhiro foaf_surname: Ikenaka bibo_doi: 10.1523/JNEUROSCI.3216-08.2009 bibo_issue: '26' bibo_volume: 29 dct_date: 2009^xs_gYear dct_publisher: Society for Neuroscience@ dct_title: Mice with altered myelin proteolipid protein gene expression display cognitive deficits accompanied by abnormal neuron-glia interactions and decreased conduction velocities@ ...