article published yes Nicole Amberg author 4CD6AAC6-F248-11E8-B48F-1D18A9856A870000-0002-3183-8207 Susanne Laukoter author 2D6B7A9A-F248-11E8-B48F-1D18A9856A870000-0002-7903-3010 Simon Hippenmeyer author 37B36620-F248-11E8-B48F-1D18A9856A870000-0003-2279-1061 SiHi department Mapping Cell-Type Specificity of the Genomic Imprintome in the Brain project Quantitative Structure-Function Analysis of Cerebral Cortex Assembly at Clonal Level project Molecular Mechanisms of Cerebral Cortex Development project Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development project The cerebral cortex is composed of a large variety of distinct cell-types including projection neurons, interneurons and glial cells which emerge from distinct neural stem cell (NSC) lineages. The vast majority of cortical projection neurons and certain classes of glial cells are generated by radial glial progenitor cells (RGPs) in a highly orchestrated manner. Recent studies employing single cell analysis and clonal lineage tracing suggest that NSC and RGP lineage progression are regulated in a profound deterministic manner. In this review we focus on recent advances based mainly on correlative phenotypic data emerging from functional genetic studies in mice. We establish hypotheses to test in future research and outline a conceptual framework how epigenetic cues modulate the generation of cell-type diversity during cortical development. This article is protected by copyright. All rights reserved. https://research-explorer.ista.ac.at/download/27/7239/2019_Wiley_Amberg.pdf application/pdfno Wiley2019 eng 00046268020000210.1111/jnc.14601 149112-26 N. Amberg, S. Laukoter, S. Hippenmeyer, Journal of Neurochemistry 149 (2019) 12–26. N. Amberg, S. Laukoter, and S. Hippenmeyer, “Epigenetic cues modulating the generation of cell type diversity in the cerebral cortex,” <i>Journal of Neurochemistry</i>, vol. 149, no. 1. Wiley, pp. 12–26, 2019. Amberg N, Laukoter S, Hippenmeyer S. Epigenetic cues modulating the generation of cell type diversity in the cerebral cortex. <i>Journal of Neurochemistry</i>. 2019;149(1):12-26. doi:<a href="https://doi.org/10.1111/jnc.14601">10.1111/jnc.14601</a> Amberg, N., Laukoter, S., &#38; Hippenmeyer, S. (2019). Epigenetic cues modulating the generation of cell type diversity in the cerebral cortex. <i>Journal of Neurochemistry</i>. Wiley. <a href="https://doi.org/10.1111/jnc.14601">https://doi.org/10.1111/jnc.14601</a> Amberg, Nicole, Susanne Laukoter, and Simon Hippenmeyer. “Epigenetic Cues Modulating the Generation of Cell Type Diversity in the Cerebral Cortex.” <i>Journal of Neurochemistry</i>. Wiley, 2019. <a href="https://doi.org/10.1111/jnc.14601">https://doi.org/10.1111/jnc.14601</a>. Amberg N, Laukoter S, Hippenmeyer S. 2019. Epigenetic cues modulating the generation of cell type diversity in the cerebral cortex. Journal of Neurochemistry. 149(1), 12–26. Amberg, Nicole, et al. “Epigenetic Cues Modulating the Generation of Cell Type Diversity in the Cerebral Cortex.” <i>Journal of Neurochemistry</i>, vol. 149, no. 1, Wiley, 2019, pp. 12–26, doi:<a href="https://doi.org/10.1111/jnc.14601">10.1111/jnc.14601</a>. 272018-12-11T11:44:14Z2025-04-14T07:43:05Z