---
_id: '27'
abstract:
- lang: eng
  text: The cerebral cortex is composed of a large variety of distinct cell-types
    including projection neurons, interneurons and glial cells which emerge from distinct
    neural stem cell (NSC) lineages. The vast majority of cortical projection neurons
    and certain classes of glial cells are generated by radial glial progenitor cells
    (RGPs) in a highly orchestrated manner. Recent studies employing single cell analysis
    and clonal lineage tracing suggest that NSC and RGP lineage progression are regulated
    in a profound deterministic manner. In this review we focus on recent advances
    based mainly on correlative phenotypic data emerging from functional genetic studies
    in mice. We establish hypotheses to test in future research and outline a conceptual
    framework how epigenetic cues modulate the generation of cell-type diversity during
    cortical development. This article is protected by copyright. All rights reserved.
acknowledgement: " This work was supported by IST Austria institutional funds; NÖ
  Forschung und Bildung \r\nn[f+b]   (C13-002)   to   SH;   a   program   grant   from
  \  the   Human   Frontiers   Science   Program (RGP0053/2014)  to SH;  the  People
  \ Programme  (Marie  Curie  Actions)  of  the  European  Union’s Seventh Framework
  Programme (FP7/2007-2013) under REA grant agreement No 618444 to SH, and the  European
  \ Research  Council  (ERC)  under  the  European  Union’s  Horizon  2020  research
  \ and innovation programme (grant agreement No 725780 LinPro)to SH.\r\n"
article_processing_charge: Yes (via OA deal)
article_type: review
author:
- first_name: Nicole
  full_name: Amberg, Nicole
  id: 4CD6AAC6-F248-11E8-B48F-1D18A9856A87
  last_name: Amberg
  orcid: 0000-0002-3183-8207
- first_name: Susanne
  full_name: Laukoter, Susanne
  id: 2D6B7A9A-F248-11E8-B48F-1D18A9856A87
  last_name: Laukoter
  orcid: 0000-0002-7903-3010
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
citation:
  ama: Amberg N, Laukoter S, Hippenmeyer S. Epigenetic cues modulating the generation
    of cell type diversity in the cerebral cortex. <i>Journal of Neurochemistry</i>.
    2019;149(1):12-26. doi:<a href="https://doi.org/10.1111/jnc.14601">10.1111/jnc.14601</a>
  apa: Amberg, N., Laukoter, S., &#38; Hippenmeyer, S. (2019). Epigenetic cues modulating
    the generation of cell type diversity in the cerebral cortex. <i>Journal of Neurochemistry</i>.
    Wiley. <a href="https://doi.org/10.1111/jnc.14601">https://doi.org/10.1111/jnc.14601</a>
  chicago: Amberg, Nicole, Susanne Laukoter, and Simon Hippenmeyer. “Epigenetic Cues
    Modulating the Generation of Cell Type Diversity in the Cerebral Cortex.” <i>Journal
    of Neurochemistry</i>. Wiley, 2019. <a href="https://doi.org/10.1111/jnc.14601">https://doi.org/10.1111/jnc.14601</a>.
  ieee: N. Amberg, S. Laukoter, and S. Hippenmeyer, “Epigenetic cues modulating the
    generation of cell type diversity in the cerebral cortex,” <i>Journal of Neurochemistry</i>,
    vol. 149, no. 1. Wiley, pp. 12–26, 2019.
  ista: Amberg N, Laukoter S, Hippenmeyer S. 2019. Epigenetic cues modulating the
    generation of cell type diversity in the cerebral cortex. Journal of Neurochemistry.
    149(1), 12–26.
  mla: Amberg, Nicole, et al. “Epigenetic Cues Modulating the Generation of Cell Type
    Diversity in the Cerebral Cortex.” <i>Journal of Neurochemistry</i>, vol. 149,
    no. 1, Wiley, 2019, pp. 12–26, doi:<a href="https://doi.org/10.1111/jnc.14601">10.1111/jnc.14601</a>.
  short: N. Amberg, S. Laukoter, S. Hippenmeyer, Journal of Neurochemistry 149 (2019)
    12–26.
corr_author: '1'
date_created: 2018-12-11T11:44:14Z
date_published: 2019-04-01T00:00:00Z
date_updated: 2025-04-14T07:43:05Z
day: '01'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1111/jnc.14601
ec_funded: 1
external_id:
  isi:
  - '000462680200002'
file:
- access_level: open_access
  checksum: db027721a95d36f5de36aadcd0bdf7e6
  content_type: application/pdf
  creator: kschuh
  date_created: 2020-01-07T13:35:52Z
  date_updated: 2020-07-14T12:45:45Z
  file_id: '7239'
  file_name: 2019_Wiley_Amberg.pdf
  file_size: 889709
  relation: main_file
file_date_updated: 2020-07-14T12:45:45Z
has_accepted_license: '1'
intvolume: '       149'
isi: 1
issue: '1'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 12-26
project:
- _id: 25D92700-B435-11E9-9278-68D0E5697425
  grant_number: LS13-002
  name: Mapping Cell-Type Specificity of the Genomic Imprintome in the Brain
- _id: 25D7962E-B435-11E9-9278-68D0E5697425
  grant_number: RGP0053/2014
  name: Quantitative Structure-Function Analysis of Cerebral Cortex Assembly at Clonal
    Level
- _id: 25D61E48-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '618444'
  name: Molecular Mechanisms of Cerebral Cortex Development
- _id: 260018B0-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '725780'
  name: Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development
publication: Journal of Neurochemistry
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Epigenetic cues modulating the generation of cell type diversity in the cerebral
  cortex
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 149
year: '2019'
...