---
res:
  bibo_abstract:
  - 'Knowledge of the rate and fitness effects of mutations is essential for understanding
    the process of evolution. Mutations are inherently difficult to study because
    they are rare and are frequently eliminated by natural selection. In the ciliate
    Tetrahymena thermophila, mutations can accumulate in the germline genome without
    being exposed to selection. We have conducted a mutation accumulation (MA) experiment
    in this species. Assuming that all mutations are deleterious and have the same
    effect, we estimate that the deleterious mutation rate per haploid germline genome
    per generation is U = 0.0047 (95% credible interval: 0.0015, 0.0125), and that
    germline mutations decrease fitness by s = 11% when expressed in a homozygous
    state (95% CI: 4.4%, 27%). We also estimate that deleterious mutations are partially
    recessive on average (h = 0.26; 95% CI: –0.022, 0.62) and that the rate of lethal
    mutations is <10% of the deleterious mutation rate. Comparisons between the
    observed evolutionary responses in the germline and somatic genomes and the results
    from individual-based simulations of MA suggest that the two genomes have similar
    mutational parameters. These are the first estimates of the deleterious mutation
    rate and fitness effects from the eukaryotic supergroup Chromalveolata and are
    within the range of those of other eukaryotes.@eng'
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Hongan
      foaf_name: Long, Hongan
      foaf_surname: Long
  - foaf_Person:
      foaf_givenName: Tiago
      foaf_name: Paixao, Tiago
      foaf_surname: Paixao
      foaf_workInfoHomepage: http://www.librecat.org/personId=2C5658E6-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-2361-3953
  - foaf_Person:
      foaf_givenName: Ricardo
      foaf_name: Azevedo, Ricardo
      foaf_surname: Azevedo
  - foaf_Person:
      foaf_givenName: Rebecca
      foaf_name: Zufall, Rebecca
      foaf_surname: Zufall
  bibo_doi: 10.1534/genetics.113.153536
  bibo_issue: '2'
  bibo_volume: 195
  dct_date: 2013^xs_gYear
  dct_identifier:
  - UT:000325286200020
  dct_language: eng
  dct_publisher: Genetics Society of America@
  dct_title: Accumulation of spontaneous mutations in the ciliate Tetrahymena thermophila@
  fabio_hasPubmedId: '23934880'
...