---
res:
  bibo_abstract:
  - 'Although cells respond specifically to environments, how environmental identity
    is encoded intracellularly is not understood. Here, we study this organization
    of information in budding yeast by estimating the mutual information between environmental
    transitions and the dynamics of nuclear translocation for 10 transcription factors.
    Our method of estimation is general, scalable, and based on decoding from single
    cells. The dynamics of the transcription factors are necessary to encode the highest
    amounts of extracellular information, and we show that information is transduced
    through two channels: Generalists (Msn2/4, Tod6 and Dot6, Maf1, and Sfp1) can
    encode the nature of multiple stresses, but only if stress is high; specialists
    (Hog1, Yap1, and Mig1/2) encode one particular stress, but do so more quickly
    and for a wider range of magnitudes. In particular, Dot6 encodes almost as much
    information as Msn2, the master regulator of the environmental stress response.
    Each transcription factor reports differently, and it is only their collective
    behavior that distinguishes between multiple environmental states. Changes in
    the dynamics of the localization of transcription factors thus constitute a precise,
    distributed internal representation of extracellular change. We predict that such
    multidimensional representations are common in cellular decision-making.@eng'
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Alejandro
      foaf_name: Granados, Alejandro
      foaf_surname: Granados
  - foaf_Person:
      foaf_givenName: Julian
      foaf_name: Pietsch, Julian
      foaf_surname: Pietsch
  - foaf_Person:
      foaf_givenName: Sarah A
      foaf_name: Cepeda Humerez, Sarah A
      foaf_surname: Cepeda Humerez
      foaf_workInfoHomepage: http://www.librecat.org/personId=3DEE19A4-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Isebail
      foaf_name: Farquhar, Isebail
      foaf_surname: Farquhar
  - foaf_Person:
      foaf_givenName: Gasper
      foaf_name: Tkacik, Gasper
      foaf_surname: Tkacik
      foaf_workInfoHomepage: http://www.librecat.org/personId=3D494DCA-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-6699-1455
  - foaf_Person:
      foaf_givenName: Peter
      foaf_name: Swain, Peter
      foaf_surname: Swain
  bibo_doi: 10.1073/pnas.1716659115
  bibo_issue: '23'
  bibo_volume: 115
  dct_date: 2018^xs_gYear
  dct_identifier:
  - UT:000434114900071
  dct_language: eng
  dct_publisher: National Academy of Sciences@
  dct_title: Distributed and dynamic intracellular organization of extracellular information@
  fabio_hasPubmedId: '29784812'
...