---
res:
  bibo_abstract:
  - Directional guidance of cells via gradients of chemokines is considered crucial
    for embryonic development, cancer dissemination, and immune responses. Nevertheless,
    the concept still lacks direct experimental confirmation in vivo. Here, we identify
    endogenous gradients of the chemokine CCL21 within mouse skin and show that they
    guide dendritic cells toward lymphatic vessels. Quantitative imaging reveals depots
    of CCL21 within lymphatic endothelial cells and steeply decaying gradients within
    the perilymphatic interstitium. These gradients match the migratory patterns of
    the dendritic cells, which directionally approach vessels from a distance of up
    to 90-micrometers. Interstitial CCL21 is immobilized to heparan sulfates, and
    its experimental delocalization or swamping the endogenous gradients abolishes
    directed migration. These findings functionally establish the concept of haptotaxis,
    directed migration along immobilized gradients, in tissues.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Michele
      foaf_name: Weber, Michele
      foaf_surname: Weber
      foaf_workInfoHomepage: http://www.librecat.org/personId=3A3FC708-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Robert
      foaf_name: Hauschild, Robert
      foaf_surname: Hauschild
      foaf_workInfoHomepage: http://www.librecat.org/personId=4E01D6B4-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-9843-3522
  - foaf_Person:
      foaf_givenName: Jan
      foaf_name: Schwarz, Jan
      foaf_surname: Schwarz
      foaf_workInfoHomepage: http://www.librecat.org/personId=346C1EC6-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Christine
      foaf_name: Moussion, Christine
      foaf_surname: Moussion
      foaf_workInfoHomepage: http://www.librecat.org/personId=3356F664-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Ingrid
      foaf_name: De Vries, Ingrid
      foaf_surname: De Vries
      foaf_workInfoHomepage: http://www.librecat.org/personId=4C7D837E-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Daniel
      foaf_name: Legler, Daniel
      foaf_surname: Legler
  - foaf_Person:
      foaf_givenName: Sanjiv
      foaf_name: Luther, Sanjiv
      foaf_surname: Luther
  - foaf_Person:
      foaf_givenName: Mark Tobias
      foaf_name: Bollenbach, Mark Tobias
      foaf_surname: Bollenbach
      foaf_workInfoHomepage: http://www.librecat.org/personId=3E6DB97A-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-4398-476X
  - foaf_Person:
      foaf_givenName: Michael K
      foaf_name: Sixt, Michael K
      foaf_surname: Sixt
      foaf_workInfoHomepage: http://www.librecat.org/personId=41E9FBEA-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-6620-9179
  bibo_doi: 10.1126/science.1228456
  bibo_issue: '6117'
  bibo_volume: 339
  dct_date: 2013^xs_gYear
  dct_identifier:
  - UT:000313622000047
  dct_language: eng
  dct_publisher: American Association for the Advancement of Science@
  dct_title: Interstitial dendritic cell guidance by haptotactic chemokine gradients@
...