---
res:
  bibo_abstract:
  - Tumor growth is caused by the acquisition of driver mutations, which enhance the
    net reproductive rate of cells. Driver mutations may increase cell division, reduce
    cell death, or allow cells to overcome density-limiting effects. We study the
    dynamics of tumor growth as one additional driver mutation is acquired. Our models
    are based on two-type branching processes that terminate in either tumor disappearance
    or tumor detection. In our first model, both cell types grow exponentially, with
    a faster rate for cells carrying the additional driver. We find that the additional
    driver mutation does not affect the survival probability of the lesion, but can
    substantially reduce the time to reach the detectable size if the lesion is slow
    growing. In our second model, cells lacking the additional driver cannot exceed
    a fixed carrying capacity, due to density limitations. In this case, the time
    to detection depends strongly on this carrying capacity. Our model provides a
    quantitative framework for studying tumor dynamics during different stages of
    progression. We observe that early, small lesions need additional drivers, while
    late stage metastases are only marginally affected by them. These results help
    to explain why additional driver mutations are typically not detected in fast-growing
    metastases.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Johannes
      foaf_name: Reiter, Johannes
      foaf_surname: Reiter
      foaf_workInfoHomepage: http://www.librecat.org/personId=4A918E98-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-0170-7353
  - foaf_Person:
      foaf_givenName: Ivana
      foaf_name: Božić, Ivana
      foaf_surname: Božić
  - foaf_Person:
      foaf_givenName: Benjamin
      foaf_name: Allen, Benjamin
      foaf_surname: Allen
      foaf_workInfoHomepage: http://www.librecat.org/personId=135B5B70-E9D2-11E9-BD74-BB415DA2B523
  - foaf_Person:
      foaf_givenName: Krishnendu
      foaf_name: Chatterjee, Krishnendu
      foaf_surname: Chatterjee
      foaf_workInfoHomepage: http://www.librecat.org/personId=2E5DCA20-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-4561-241X
  - foaf_Person:
      foaf_givenName: Martin
      foaf_name: Nowak, Martin
      foaf_surname: Nowak
  bibo_doi: 10.1111/eva.12020
  bibo_issue: '1'
  bibo_volume: 6
  dct_date: 2013^xs_gYear
  dct_identifier:
  - UT:000313878800004
  dct_language: eng
  dct_publisher: Wiley-Blackwell@
  dct_title: The effect of one additional driver mutation on tumor progression@
...