article published yes Jerome Kelleher author Nicholas H Barton author 4880FE40-F248-11E8-B48F-1D18A9856A870000-0002-8548-5240 Alison Etheridge author NiBa department Limits to selection in biology and in evolutionary computation project Coalescent simulation has become an indispensable tool in population genetics and many complex evolutionary scenarios have been incorporated into the basic algorithm. Despite many years of intense interest in spatial structure, however, there are no available methods to simulate the ancestry of a sample of genes that occupy a spatial continuum. This is mainly due to the severe technical problems encountered by the classical model of isolation by distance. A recently introduced model solves these technical problems and provides a solid theoretical basis for the study of populations evolving in continuous space. We present a detailed algorithm to simulate the coalescent process in this model, and provide an efficient implementation of a generalised version of this algorithm as a freely available Python module. https://research-explorer.ista.ac.at/download/2910/5189/IST-2016-556-v1+1_bioinformatics-2013.pdf application/pdfno Oxford University Press2013 eng 00031669570002010.1093/bioinformatics/btt067 297955 - 956 Kelleher, J., Barton, N. H., &#38; Etheridge, A. (2013). Coalescent simulation in continuous space. <i>Bioinformatics</i>. Oxford University Press. <a href="https://doi.org/10.1093/bioinformatics/btt067">https://doi.org/10.1093/bioinformatics/btt067</a> J. Kelleher, N.H. Barton, A. Etheridge, Bioinformatics 29 (2013) 955–956. Kelleher, Jerome, et al. “Coalescent Simulation in Continuous Space.” <i>Bioinformatics</i>, vol. 29, no. 7, Oxford University Press, 2013, pp. 955–56, doi:<a href="https://doi.org/10.1093/bioinformatics/btt067">10.1093/bioinformatics/btt067</a>. Kelleher J, Barton NH, Etheridge A. Coalescent simulation in continuous space. <i>Bioinformatics</i>. 2013;29(7):955-956. doi:<a href="https://doi.org/10.1093/bioinformatics/btt067">10.1093/bioinformatics/btt067</a> Kelleher, Jerome, Nicholas H Barton, and Alison Etheridge. “Coalescent Simulation in Continuous Space.” <i>Bioinformatics</i>. Oxford University Press, 2013. <a href="https://doi.org/10.1093/bioinformatics/btt067">https://doi.org/10.1093/bioinformatics/btt067</a>. Kelleher J, Barton NH, Etheridge A. 2013. Coalescent simulation in continuous space. Bioinformatics. 29(7), 955–956. J. Kelleher, N. H. Barton, and A. Etheridge, “Coalescent simulation in continuous space,” <i>Bioinformatics</i>, vol. 29, no. 7. Oxford University Press, pp. 955–956, 2013. 29102018-12-11T12:00:17Z2025-09-29T13:30:36Z