---
_id: '2910'
abstract:
- lang: eng
  text: "Coalescent simulation has become an indispensable tool in population genetics
    and many complex evolutionary scenarios have been incorporated into the basic
    algorithm. Despite many years of intense interest in spatial structure, however,
    there are no available methods to simulate the ancestry of a sample of genes that
    occupy a spatial continuum. This is mainly due to the severe technical problems
    encountered by the classical model of isolation\r\nby distance. A recently introduced
    model solves these technical problems and provides a solid theoretical basis for
    the study of populations evolving in continuous space. We present a detailed algorithm
    to simulate the coalescent process in this model, and provide an efficient implementation
    of a generalised version of this algorithm as a freely available Python module."
article_processing_charge: No
author:
- first_name: Jerome
  full_name: Kelleher, Jerome
  last_name: Kelleher
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
- first_name: Alison
  full_name: Etheridge, Alison
  last_name: Etheridge
citation:
  ama: Kelleher J, Barton NH, Etheridge A. Coalescent simulation in continuous space.
    <i>Bioinformatics</i>. 2013;29(7):955-956. doi:<a href="https://doi.org/10.1093/bioinformatics/btt067">10.1093/bioinformatics/btt067</a>
  apa: Kelleher, J., Barton, N. H., &#38; Etheridge, A. (2013). Coalescent simulation
    in continuous space. <i>Bioinformatics</i>. Oxford University Press. <a href="https://doi.org/10.1093/bioinformatics/btt067">https://doi.org/10.1093/bioinformatics/btt067</a>
  chicago: Kelleher, Jerome, Nicholas H Barton, and Alison Etheridge. “Coalescent
    Simulation in Continuous Space.” <i>Bioinformatics</i>. Oxford University Press,
    2013. <a href="https://doi.org/10.1093/bioinformatics/btt067">https://doi.org/10.1093/bioinformatics/btt067</a>.
  ieee: J. Kelleher, N. H. Barton, and A. Etheridge, “Coalescent simulation in continuous
    space,” <i>Bioinformatics</i>, vol. 29, no. 7. Oxford University Press, pp. 955–956,
    2013.
  ista: Kelleher J, Barton NH, Etheridge A. 2013. Coalescent simulation in continuous
    space. Bioinformatics. 29(7), 955–956.
  mla: Kelleher, Jerome, et al. “Coalescent Simulation in Continuous Space.” <i>Bioinformatics</i>,
    vol. 29, no. 7, Oxford University Press, 2013, pp. 955–56, doi:<a href="https://doi.org/10.1093/bioinformatics/btt067">10.1093/bioinformatics/btt067</a>.
  short: J. Kelleher, N.H. Barton, A. Etheridge, Bioinformatics 29 (2013) 955–956.
corr_author: '1'
date_created: 2018-12-11T12:00:17Z
date_published: 2013-02-07T00:00:00Z
date_updated: 2025-09-29T13:30:36Z
day: '07'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1093/bioinformatics/btt067
ec_funded: 1
external_id:
  isi:
  - '000316695700020'
file:
- access_level: open_access
  checksum: a3b54d7477fac923815ac082403d9bd0
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:16:04Z
  date_updated: 2020-07-14T12:45:52Z
  file_id: '5189'
  file_name: IST-2016-556-v1+1_bioinformatics-2013.pdf
  file_size: 170197
  relation: main_file
file_date_updated: 2020-07-14T12:45:52Z
has_accepted_license: '1'
intvolume: '        29'
isi: 1
issue: '7'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: 955 - 956
project:
- _id: 25B07788-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '250152'
  name: Limits to selection in biology and in evolutionary computation
publication: Bioinformatics
publication_status: published
publisher: Oxford University Press
publist_id: '3833'
pubrep_id: '556'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Coalescent simulation in continuous space
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 29
year: '2013'
...