---
res:
  bibo_abstract:
  - MicroRNAs (miRNAs) are small noncoding RNAs that function in literally all cellular
    processes. miRNAs interact with Argonaute (Ago) proteins and guide them to specific
    target sites located in the 3′-untranslated region (3′-UTR) of target mRNAs leading
    to translational repression and deadenylation-induced mRNA degradation. Most miRNAs
    are processed from hairpin-structured precursors by the consecutive action of
    the RNase III enzymes Drosha and Dicer. However, processing of miR-451 is Dicer
    independent and cleavage is mediated by the endonuclease Ago2. Here we have characterized
    miR-451 sequence and structure requirements for processing as well as sorting
    of miRNAs into different Ago proteins. Pre-miR-451 appears to be optimized for
    Ago2 cleavage and changes result in reduced processing. In addition, we show that
    the mature miR-451 only associates with Ago2 suggesting that mature miRNAs are
    not exchanged between different members of the Ago protein family. Based on cloning
    and deep sequencing of endogenous miRNAs associated with Ago1-3, we do not find
    evidence for miRNA sorting in human cells. However, Ago identity appears to influence
    the length of some miRNAs, while others remain unaffected.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Anne
      foaf_name: Dueck, Anne
      foaf_surname: Dueck
  - foaf_Person:
      foaf_givenName: Christian
      foaf_name: Ziegler, Christian
      foaf_surname: Ziegler
  - foaf_Person:
      foaf_givenName: Alexander
      foaf_name: Eichner, Alexander
      foaf_surname: Eichner
      foaf_workInfoHomepage: http://www.librecat.org/personId=4DFA52AE-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Eugène
      foaf_name: Berezikov, Eugène
      foaf_surname: Berezikov
  - foaf_Person:
      foaf_givenName: Gunter
      foaf_name: Meister, Gunter
      foaf_surname: Meister
  bibo_doi: 10.1093/nar/gks705
  bibo_issue: '19'
  bibo_volume: 40
  dct_date: 2012^xs_gYear
  dct_identifier:
  - UT:000310377200046
  dct_language: eng
  dct_publisher: Oxford University Press@
  dct_title: MicroRNAs associated with the different human Argonaute proteins@
...