---
_id: '2951'
abstract:
- lang: eng
  text: Differential cell adhesion and cortex tension are thought to drive cell sorting
    by controlling cell-cell contact formation. Here, we show that cell adhesion and
    cortex tension have different mechanical functions in controlling progenitor cell-cell
    contact formation and sorting during zebrafish gastrulation. Cortex tension controls
    cell-cell contact expansion by modulating interfacial tension at the contact.
    By contrast, adhesion has little direct function in contact expansion, but instead
    is needed to mechanically couple the cortices of adhering cells at their contacts,
    allowing cortex tension to control contact expansion. The coupling function of
    adhesion is mediated by E-cadherin and limited by the mechanical anchoring of
    E-cadherin to the cortex. Thus, cell adhesion provides the mechanical scaffold
    for cell cortex tension to drive cell sorting during gastrulation.
acknowledged_ssus:
- _id: SSU
article_processing_charge: No
author:
- first_name: Jean-Léon
  full_name: Maître, Jean-Léon
  id: 48F1E0D8-F248-11E8-B48F-1D18A9856A87
  last_name: Maître
  orcid: 0000-0002-3688-1474
- first_name: Hélène
  full_name: Berthoumieux, Hélène
  last_name: Berthoumieux
- first_name: Gabriel
  full_name: Krens, Gabriel
  id: 2B819732-F248-11E8-B48F-1D18A9856A87
  last_name: Krens
  orcid: 0000-0003-4761-5996
- first_name: Guillaume
  full_name: Salbreux, Guillaume
  last_name: Salbreux
- first_name: Frank
  full_name: Julicher, Frank
  last_name: Julicher
- first_name: Ewa
  full_name: Paluch, Ewa
  last_name: Paluch
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: Maître J-L, Berthoumieux H, Krens G, et al. Adhesion functions in cell sorting
    by mechanically coupling the cortices of adhering cells. <i>Science</i>. 2012;338(6104):253-256.
    doi:<a href="https://doi.org/10.1126/science.1225399">10.1126/science.1225399</a>
  apa: Maître, J.-L., Berthoumieux, H., Krens, G., Salbreux, G., Julicher, F., Paluch,
    E., &#38; Heisenberg, C.-P. J. (2012). Adhesion functions in cell sorting by mechanically
    coupling the cortices of adhering cells. <i>Science</i>. American Association
    for the Advancement of Science. <a href="https://doi.org/10.1126/science.1225399">https://doi.org/10.1126/science.1225399</a>
  chicago: Maître, Jean-Léon, Hélène Berthoumieux, Gabriel Krens, Guillaume Salbreux,
    Frank Julicher, Ewa Paluch, and Carl-Philipp J Heisenberg. “Adhesion Functions
    in Cell Sorting by Mechanically Coupling the Cortices of Adhering Cells.” <i>Science</i>.
    American Association for the Advancement of Science, 2012. <a href="https://doi.org/10.1126/science.1225399">https://doi.org/10.1126/science.1225399</a>.
  ieee: J.-L. Maître <i>et al.</i>, “Adhesion functions in cell sorting by mechanically
    coupling the cortices of adhering cells,” <i>Science</i>, vol. 338, no. 6104.
    American Association for the Advancement of Science, pp. 253–256, 2012.
  ista: Maître J-L, Berthoumieux H, Krens G, Salbreux G, Julicher F, Paluch E, Heisenberg
    C-PJ. 2012. Adhesion functions in cell sorting by mechanically coupling the cortices
    of adhering cells. Science. 338(6104), 253–256.
  mla: Maître, Jean-Léon, et al. “Adhesion Functions in Cell Sorting by Mechanically
    Coupling the Cortices of Adhering Cells.” <i>Science</i>, vol. 338, no. 6104,
    American Association for the Advancement of Science, 2012, pp. 253–56, doi:<a
    href="https://doi.org/10.1126/science.1225399">10.1126/science.1225399</a>.
  short: J.-L. Maître, H. Berthoumieux, G. Krens, G. Salbreux, F. Julicher, E. Paluch,
    C.-P.J. Heisenberg, Science 338 (2012) 253–256.
corr_author: '1'
date_created: 2018-12-11T12:00:31Z
date_published: 2012-10-12T00:00:00Z
date_updated: 2025-09-30T08:10:36Z
day: '12'
department:
- _id: CaHe
doi: 10.1126/science.1225399
external_id:
  isi:
  - '000309712300045'
intvolume: '       338'
isi: 1
issue: '6104'
language:
- iso: eng
month: '10'
oa_version: None
page: 253 - 256
publication: Science
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '3777'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Adhesion functions in cell sorting by mechanically coupling the cortices of
  adhering cells
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 338
year: '2012'
...