---
res:
  bibo_abstract:
  - Spontaneous postsynaptic currents (PSCs) provide key information about the mechanisms
    of synaptic transmission and the activity modes of neuronal networks. However,
    detecting spontaneous PSCs in vitro and in vivo has been challenging, because
    of the small amplitude, the variable kinetics, and the undefined time of generation
    of these events. Here, we describe a, to our knowledge, new method for detecting
    spontaneous synaptic events by deconvolution, using a template that approximates
    the average time course of spontaneous PSCs. A recorded PSC trace is deconvolved
    from the template, resulting in a series of delta-like functions. The maxima of
    these delta-like events are reliably detected, revealing the precise onset times
    of the spontaneous PSCs. Among all detection methods, the deconvolution-based
    method has a unique temporal resolution, allowing the detection of individual
    events in high-frequency bursts. Furthermore, the deconvolution-based method has
    a high amplitude resolution, because deconvolution can substantially increase
    the signal/noise ratio. When tested against previously published methods using
    experimental data, the deconvolution-based method was superior for spontaneous
    PSCs recorded in vivo. Using the high-resolution deconvolution-based detection
    algorithm, we show that the frequency of spontaneous excitatory postsynaptic currents
    in dentate gyrus granule cells is 4.5 times higher in vivo than in vitro.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Alejandro
      foaf_name: Pernia-Andrade, Alejandro
      foaf_surname: Pernia-Andrade
      foaf_workInfoHomepage: http://www.librecat.org/personId=36963E98-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Sarit
      foaf_name: Goswami, Sarit
      foaf_surname: Goswami
      foaf_workInfoHomepage: http://www.librecat.org/personId=3A578F32-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Yvonne
      foaf_name: Stickler, Yvonne
      foaf_surname: Stickler
      foaf_workInfoHomepage: http://www.librecat.org/personId=63B76600-E9CC-11E9-9B5F-82450873F7A1
  - foaf_Person:
      foaf_givenName: Ulrich
      foaf_name: Fröbe, Ulrich
      foaf_surname: Fröbe
  - foaf_Person:
      foaf_givenName: Alois
      foaf_name: Schlögl, Alois
      foaf_surname: Schlögl
      foaf_workInfoHomepage: http://www.librecat.org/personId=45BF87EE-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-5621-8100
  - foaf_Person:
      foaf_givenName: Peter M
      foaf_name: Jonas, Peter M
      foaf_surname: Jonas
      foaf_workInfoHomepage: http://www.librecat.org/personId=353C1B58-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-5001-4804
  bibo_doi: 10.1016/j.bpj.2012.08.039
  bibo_issue: '7'
  bibo_volume: 103
  dct_date: 2012^xs_gYear
  dct_identifier:
  - UT:000309571400005
  dct_language: eng
  dct_publisher: Biophysical Society@
  dct_title: A deconvolution based method with high sensitivity and temporal resolution
    for detection of spontaneous synaptic currents in vitro and in vivo@
  fabio_hasPubmedId: '23062335'
...