---
_id: '2958'
abstract:
- lang: eng
text: 'The activity of hippocampal pyramidal cells reflects both the current position
of the animal and information related to its current behavior. Here we investigated
whether single hippocampal neurons can encode several independent features defining
trials during a memory task. We also tested whether task-related information is
represented by partial remapping of the place cell population or, instead, via
firing rate modulation of spatially stable place cells. To address these two questions,
the activity of hippocampal neurons was recorded in rats performing a conditional
discrimination task on a modified T-maze in which the identity of a food reward
guided behavior. When the rat was on the central arm of the maze, the firing rate
of pyramidal cells changed depending on two independent factors: (1) the identity
of the food reward given to the animal and (2) the previous location of the animal
on the maze. Importantly, some pyramidal cells encoded information relative to
both factors. This trial-type specific and retrospective coding did not interfere
with the spatial representation of the maze: hippocampal cells had stable place
fields and their theta-phase precession profiles were unaltered during the task,
indicating that trial-related information was encoded via rate remapping. During
error trials, encoding of both trial-related information and spatial location
was impaired. Finally, we found that pyramidal cells also encode trial-related
information via rate remapping during the continuous version of the rewarded alternation
task without delays. These results suggest that hippocampal neurons can encode
several task-related cognitive aspects via rate remapping.'
acknowledgement: J.C. was supported by a MRC Intramural Programme Grant (U138197111)
and a European Research Council Starter Grant (281511). K.A. held a Wellcome Trust
PhD studentship and a Humboldt Research Fellowship for Postdoctoral Researchers.
D.M.B. was supported by Wellcome Trust Senior Fellowships (074385 and 087736).
author:
- first_name: Kevin
full_name: Allen, Kevin
last_name: Allen
- first_name: J Nick
full_name: Rawlins, J Nick
last_name: Rawlins
- first_name: David
full_name: Bannerman, David
last_name: Bannerman
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Allen K, Rawlins JN, Bannerman D, Csicsvari JL. Hippocampal place cells can
encode multiple trial-dependent features through rate remapping. Journal of
Neuroscience. 2012;32(42):14752-14766. doi:10.1523/JNEUROSCI.6175-11.2012
apa: Allen, K., Rawlins, J. N., Bannerman, D., & Csicsvari, J. L. (2012). Hippocampal
place cells can encode multiple trial-dependent features through rate remapping.
Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.6175-11.2012
chicago: Allen, Kevin, J Nick Rawlins, David Bannerman, and Jozsef L Csicsvari.
“Hippocampal Place Cells Can Encode Multiple Trial-Dependent Features through
Rate Remapping.” Journal of Neuroscience. Society for Neuroscience, 2012.
https://doi.org/10.1523/JNEUROSCI.6175-11.2012.
ieee: K. Allen, J. N. Rawlins, D. Bannerman, and J. L. Csicsvari, “Hippocampal place
cells can encode multiple trial-dependent features through rate remapping,” Journal
of Neuroscience, vol. 32, no. 42. Society for Neuroscience, pp. 14752–14766,
2012.
ista: Allen K, Rawlins JN, Bannerman D, Csicsvari JL. 2012. Hippocampal place cells
can encode multiple trial-dependent features through rate remapping. Journal of
Neuroscience. 32(42), 14752–14766.
mla: Allen, Kevin, et al. “Hippocampal Place Cells Can Encode Multiple Trial-Dependent
Features through Rate Remapping.” Journal of Neuroscience, vol. 32, no.
42, Society for Neuroscience, 2012, pp. 14752–66, doi:10.1523/JNEUROSCI.6175-11.2012.
short: K. Allen, J.N. Rawlins, D. Bannerman, J.L. Csicsvari, Journal of Neuroscience
32 (2012) 14752–14766.
date_created: 2018-12-11T12:00:33Z
date_published: 2012-10-17T00:00:00Z
date_updated: 2021-01-12T07:40:03Z
day: '17'
department:
- _id: JoCs
doi: 10.1523/JNEUROSCI.6175-11.2012
ec_funded: 1
external_id:
pmid:
- '23077060'
intvolume: ' 32'
issue: '42'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531717/
month: '10'
oa: 1
oa_version: Submitted Version
page: 14752 - 14766
pmid: 1
project:
- _id: 257A4776-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281511'
name: Memory-related information processing in neuronal circuits of the hippocampus
and entorhinal cortex
publication: Journal of Neuroscience
publication_status: published
publisher: Society for Neuroscience
publist_id: '3768'
quality_controlled: '1'
scopus_import: 1
status: public
title: Hippocampal place cells can encode multiple trial-dependent features through
rate remapping
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 32
year: '2012'
...