{"date_published":"2002-02-19T00:00:00Z","publication":"Current Biology","publication_status":"published","day":"19","doi":"10.1016/S0960-9822(02)00654-1","author":[{"full_name":"Grebe, Markus","last_name":"Grebe","first_name":"Markus"},{"first_name":"Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596","full_name":"Friml, Jirí","last_name":"Friml"},{"first_name":"Ranjan","last_name":"Swarup","full_name":"Swarup, Ranjan"},{"full_name":"Ljung, Karin","last_name":"Ljung","first_name":"Karin"},{"first_name":"Göran","full_name":"Sandberg, Göran","last_name":"Sandberg"},{"full_name":"Terlou, Maarten","last_name":"Terlou","first_name":"Maarten"},{"last_name":"Palme","full_name":"Palme, Klaus","first_name":"Klaus"},{"last_name":"Bennett","full_name":"Bennett, Malcolm","first_name":"Malcolm"},{"full_name":"Scheres, Ben","last_name":"Scheres","first_name":"Ben"}],"pmid":1,"volume":12,"_id":"2988","external_id":{"pmid":["11864575"]},"intvolume":"        12","quality_controlled":"1","language":[{"iso":"eng"}],"publist_id":"3714","page":"329 - 334","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_created":"2018-12-11T12:00:43Z","citation":{"chicago":"Grebe, Markus, Jiří Friml, Ranjan Swarup, Karin Ljung, Göran Sandberg, Maarten Terlou, Klaus Palme, Malcolm Bennett, and Ben Scheres. “Cell Polarity Signaling in Arabidopsis Involves a BFA Sensitive Auxin Influx Pathway.” <i>Current Biology</i>. Cell Press, 2002. <a href=\"https://doi.org/10.1016/S0960-9822(02)00654-1\">https://doi.org/10.1016/S0960-9822(02)00654-1</a>.","apa":"Grebe, M., Friml, J., Swarup, R., Ljung, K., Sandberg, G., Terlou, M., … Scheres, B. (2002). Cell polarity signaling in Arabidopsis involves a BFA sensitive auxin influx pathway. <i>Current Biology</i>. Cell Press. <a href=\"https://doi.org/10.1016/S0960-9822(02)00654-1\">https://doi.org/10.1016/S0960-9822(02)00654-1</a>","short":"M. Grebe, J. Friml, R. Swarup, K. Ljung, G. Sandberg, M. Terlou, K. Palme, M. Bennett, B. Scheres, Current Biology 12 (2002) 329–334.","ista":"Grebe M, Friml J, Swarup R, Ljung K, Sandberg G, Terlou M, Palme K, Bennett M, Scheres B. 2002. Cell polarity signaling in Arabidopsis involves a BFA sensitive auxin influx pathway. Current Biology. 12(4), 329–334.","ama":"Grebe M, Friml J, Swarup R, et al. Cell polarity signaling in Arabidopsis involves a BFA sensitive auxin influx pathway. <i>Current Biology</i>. 2002;12(4):329-334. doi:<a href=\"https://doi.org/10.1016/S0960-9822(02)00654-1\">10.1016/S0960-9822(02)00654-1</a>","ieee":"M. Grebe <i>et al.</i>, “Cell polarity signaling in Arabidopsis involves a BFA sensitive auxin influx pathway,” <i>Current Biology</i>, vol. 12, no. 4. Cell Press, pp. 329–334, 2002.","mla":"Grebe, Markus, et al. “Cell Polarity Signaling in Arabidopsis Involves a BFA Sensitive Auxin Influx Pathway.” <i>Current Biology</i>, vol. 12, no. 4, Cell Press, 2002, pp. 329–34, doi:<a href=\"https://doi.org/10.1016/S0960-9822(02)00654-1\">10.1016/S0960-9822(02)00654-1</a>."},"type":"journal_article","title":"Cell polarity signaling in Arabidopsis involves a BFA sensitive auxin influx pathway","date_updated":"2023-07-17T12:15:28Z","month":"02","article_processing_charge":"No","scopus_import":"1","publisher":"Cell Press","issue":"4","year":"2002","abstract":[{"text":"Coordination of cell and tissue polarity commonly involves directional signaling [1]. In the Arabidopsis root epidermis, cell polarity is revealed by basal, root tip-oriented, hair outgrowth from hair-forming cells (trichoblasts) [2]. The plant hormone auxin displays polar movements [1, 3] and accumulates at maximum concentration in the root tip [4, 5]. The application of polar auxin transport inhibitors [3] evokes changes in trichoblast polarity only at high concentrations and after long-term application [2, 4]. Thus, it remains open whether components of the auxin transport machinery mediate establishment of trichoblast polarity. Here we report that the presumptive auxin influx carrier AUX1 [6, 7] contributes to apical-basal hair cell polarity. AUX1 function is required for polarity changes induced by exogenous application of the auxin 2,4-D, a preferential influx carrier substrate. Similar to aux1 mutants, the vesicle trafficking inhibitor brefeldin A (BFA) interferes with polar hair initiation, and AUX1 function is required for BFA-mediated polarity changes. Consistently, BFA inhibits membrane trafficking of AUX1, trichoblast hyperpolarization induced by 2,4-D, and alters the distal auxin maximum. Our results identify AUX1 as one component of a novel BFA-sensitive auxin transport pathway polarizing cells toward a hormone maximum.","lang":"eng"}],"publication_identifier":{"issn":["0960-9822"]},"oa_version":"None","article_type":"original","extern":"1","status":"public"}