article published yes Jirí Friml author 4159519E-F248-11E8-B48F-1D18A9856A870000-0002-8302-7596 Eva Benková author 38F4F166-F248-11E8-B48F-1D18A9856A870000-0002-8510-9739 Ikram Blilou author Justyna Wiśniewska author Thorsten Hamann author Karin Ljung author Scott Woody author Göran Sandberg author Ben Scheres author Gerd Jürgens author Klaus Palme author In contrast to animals, little is known about pattern formation in plants. Physiological and genetic data suggest the involvement of the phytohormone auxin in this process. Here, we characterize a novel member of the PIN family of putative auxin efflux carriers, Arabidopsis PIN4, that is localized in developing and mature root meristems. Atpin4 mutants are defective in establishment and maintenance of endogenous auxin gradients, fail to canalize externally applied auxin, and display various patterning defects in both embryonic and seedling roots. We propose a role for AtPIN4 in generating a sink for auxin below the quiescent center of the root meristem that is essential for auxin distribution and patterning. Cell Press2002 eng 0092-8674 1189333710.1016/S0092-8674(02)00656-6 1085661 - 673 yes J. Friml, E. Benková, I. Blilou, J. Wiśniewska, T. Hamann, K. Ljung, S. Woody, G. Sandberg, B. Scheres, G. Jürgens, K. Palme, Cell 108 (2002) 661–673. Friml J, Benková E, Blilou I, Wiśniewska J, Hamann T, Ljung K, Woody S, Sandberg G, Scheres B, Jürgens G, Palme K. 2002. AtPIN4 mediates sink-driven auxin gradients and root patterning in Arabidopsis. Cell. 108(5), 661–673. Friml, Jiří, et al. “AtPIN4 Mediates Sink-Driven Auxin Gradients and Root Patterning in Arabidopsis.” <i>Cell</i>, vol. 108, no. 5, Cell Press, 2002, pp. 661–73, doi:<a href="https://doi.org/10.1016/S0092-8674(02)00656-6">10.1016/S0092-8674(02)00656-6</a>. J. Friml <i>et al.</i>, “AtPIN4 mediates sink-driven auxin gradients and root patterning in Arabidopsis,” <i>Cell</i>, vol. 108, no. 5. Cell Press, pp. 661–673, 2002. Friml J, Benková E, Blilou I, et al. AtPIN4 mediates sink-driven auxin gradients and root patterning in Arabidopsis. <i>Cell</i>. 2002;108(5):661-673. doi:<a href="https://doi.org/10.1016/S0092-8674(02)00656-6">10.1016/S0092-8674(02)00656-6</a> Friml, Jiří, Eva Benková, Ikram Blilou, Justyna Wiśniewska, Thorsten Hamann, Karin Ljung, Scott Woody, et al. “AtPIN4 Mediates Sink-Driven Auxin Gradients and Root Patterning in Arabidopsis.” <i>Cell</i>. Cell Press, 2002. <a href="https://doi.org/10.1016/S0092-8674(02)00656-6">https://doi.org/10.1016/S0092-8674(02)00656-6</a>. Friml, J., Benková, E., Blilou, I., Wiśniewska, J., Hamann, T., Ljung, K., … Palme, K. (2002). AtPIN4 mediates sink-driven auxin gradients and root patterning in Arabidopsis. <i>Cell</i>. Cell Press. <a href="https://doi.org/10.1016/S0092-8674(02)00656-6">https://doi.org/10.1016/S0092-8674(02)00656-6</a> 29892018-12-11T12:00:43Z2023-07-17T11:57:40Z