---
res:
  bibo_abstract:
  - SETD5 gene mutations have been identified as a frequent cause of idiopathic intellectual
    disability. Here we show that Setd5-haploinsufficient mice present developmental
    defects such as abnormal brain-to-body weight ratios and neural crest defect-associated
    phenotypes. Furthermore, Setd5-mutant mice show impairments in cognitive tasks,
    enhanced long-term potentiation, delayed ontogenetic profile of ultrasonic vocalization,
    and behavioral inflexibility. Behavioral issues are accompanied by abnormal expression
    of postsynaptic density proteins previously associated with cognition. Our data
    additionally indicate that Setd5 regulates RNA polymerase II dynamics and gene
    transcription via its interaction with the Hdac3 and Paf1 complexes, findings
    potentially explaining the gene expression defects observed in Setd5-haploinsufficient
    mice. Our results emphasize the decisive role of Setd5 in a biological pathway
    found to be disrupted in humans with intellectual disability and autism spectrum
    disorder.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Elena
      foaf_name: Deliu, Elena
      foaf_surname: Deliu
      foaf_workInfoHomepage: http://www.librecat.org/personId=37A40D7E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-7370-5293
  - foaf_Person:
      foaf_givenName: Niccoló
      foaf_name: Arecco, Niccoló
      foaf_surname: Arecco
  - foaf_Person:
      foaf_givenName: Jasmin
      foaf_name: Morandell, Jasmin
      foaf_surname: Morandell
      foaf_workInfoHomepage: http://www.librecat.org/personId=4739D480-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Christoph
      foaf_name: Dotter, Christoph
      foaf_surname: Dotter
      foaf_workInfoHomepage: http://www.librecat.org/personId=4C66542E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-9033-9096
  - foaf_Person:
      foaf_givenName: Ximena
      foaf_name: Contreras, Ximena
      foaf_surname: Contreras
      foaf_workInfoHomepage: http://www.librecat.org/personId=475990FE-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Charles
      foaf_name: Girardot, Charles
      foaf_surname: Girardot
  - foaf_Person:
      foaf_givenName: Eva
      foaf_name: Käsper, Eva
      foaf_surname: Käsper
  - foaf_Person:
      foaf_givenName: Alena
      foaf_name: Kozlova, Alena
      foaf_surname: Kozlova
      foaf_workInfoHomepage: http://www.librecat.org/personId=C50A9596-02D0-11E9-976E-E38CFE5CBC1D
  - foaf_Person:
      foaf_givenName: Kasumi
      foaf_name: Kishi, Kasumi
      foaf_surname: Kishi
      foaf_workInfoHomepage: http://www.librecat.org/personId=3065DFC4-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-6060-4795
  - foaf_Person:
      foaf_givenName: Ilaria
      foaf_name: Chiaradia, Ilaria
      foaf_surname: Chiaradia
      foaf_workInfoHomepage: http://www.librecat.org/personId=B6467F20-02D0-11E9-BDA5-E960C241894A
    orcid: 0000-0002-9529-4464
  - foaf_Person:
      foaf_givenName: Kyung
      foaf_name: Noh, Kyung
      foaf_surname: Noh
  - foaf_Person:
      foaf_givenName: Gaia
      foaf_name: Novarino, Gaia
      foaf_surname: Novarino
      foaf_workInfoHomepage: http://www.librecat.org/personId=3E57A680-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-7673-7178
  bibo_doi: 10.1038/s41593-018-0266-2
  bibo_issue: '12'
  bibo_volume: 21
  dct_date: 2018^xs_gYear
  dct_identifier:
  - UT:000451324700010
  dct_language: eng
  dct_publisher: Nature Publishing Group@
  dct_title: Haploinsufficiency of the intellectual disability gene SETD5 disturbs
    developmental gene expression and cognition@
...