---
_id: '3007'
abstract:
- lang: eng
text: Root gravitropism describes the orientation of root growth along the gravity
vector and is mediated by differential cell elongation in the root meristem. This
response requires the coordinated, asymmetric distribution of the phytohormone
auxin within the root meristem, and depends on the concerted activities of PIN
proteins and AUX1 - members of the auxin transport pathway. Here, we show that
intracellular trafficking and proteasome activity combine to control PIN2 degradation
during root gravitropism. Following gravi-stimulation, proteasome-dependent variations
in PIN2 localization and degradation at the upper and lower sides of the root
result in asymmetric distribution of PIN2. Ubiquitination of PIN2 occurs in a
proteasome-dependent manner, indicating that the proteasome is involved in the
control of PIN2 turnover. Stabilization of PIN2 affects its abundance and distribution,
and leads to defects in auxin distribution and gravitropic responses. We describe
the effects of auxin on PIN2 localization and protein levels, indicating that
redistribution of auxin during the gravitropic response may be involved in the
regulation of PIN2 protein.
author:
- first_name: Lindy
full_name: Abas, Lindy
last_name: Abas
- first_name: René
full_name: Benjamins, René
last_name: Benjamins
- first_name: Nenad
full_name: Malenica, Nenad
last_name: Malenica
- first_name: Tomasz
full_name: Paciorek, Tomasz
last_name: Paciorek
- first_name: Justyna
full_name: Wiśniewska, Justyna
last_name: Wiśniewska
- first_name: Jeanette
full_name: Moulinier-Anzola, Jeanette C
last_name: Moulinier Anzola
- first_name: Tobias
full_name: Sieberer, Tobias
last_name: Sieberer
- first_name: Jirí
full_name: Jirí Friml
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Christian
full_name: Luschnig, Christian
last_name: Luschnig
citation:
ama: Abas L, Benjamins R, Malenica N, et al. Intracellular trafficking and proteolysis
of the Arabidopsis auxin-efflux facilitator PIN2 are involved in root gravitropism.
Nature Cell Biology. 2006;8(3):249-256. doi:10.1038/ncb1369
apa: Abas, L., Benjamins, R., Malenica, N., Paciorek, T., Wiśniewska, J., Moulinier
Anzola, J., … Luschnig, C. (2006). Intracellular trafficking and proteolysis of
the Arabidopsis auxin-efflux facilitator PIN2 are involved in root gravitropism.
Nature Cell Biology. Nature Publishing Group. https://doi.org/10.1038/ncb1369
chicago: Abas, Lindy, René Benjamins, Nenad Malenica, Tomasz Paciorek, Justyna Wiśniewska,
Jeanette Moulinier Anzola, Tobias Sieberer, Jiří Friml, and Christian Luschnig.
“Intracellular Trafficking and Proteolysis of the Arabidopsis Auxin-Efflux Facilitator
PIN2 Are Involved in Root Gravitropism.” Nature Cell Biology. Nature Publishing
Group, 2006. https://doi.org/10.1038/ncb1369.
ieee: L. Abas et al., “Intracellular trafficking and proteolysis of the Arabidopsis
auxin-efflux facilitator PIN2 are involved in root gravitropism,” Nature Cell
Biology, vol. 8, no. 3. Nature Publishing Group, pp. 249–256, 2006.
ista: Abas L, Benjamins R, Malenica N, Paciorek T, Wiśniewska J, Moulinier Anzola
J, Sieberer T, Friml J, Luschnig C. 2006. Intracellular trafficking and proteolysis
of the Arabidopsis auxin-efflux facilitator PIN2 are involved in root gravitropism.
Nature Cell Biology. 8(3), 249–256.
mla: Abas, Lindy, et al. “Intracellular Trafficking and Proteolysis of the Arabidopsis
Auxin-Efflux Facilitator PIN2 Are Involved in Root Gravitropism.” Nature Cell
Biology, vol. 8, no. 3, Nature Publishing Group, 2006, pp. 249–56, doi:10.1038/ncb1369.
short: L. Abas, R. Benjamins, N. Malenica, T. Paciorek, J. Wiśniewska, J. Moulinier
Anzola, T. Sieberer, J. Friml, C. Luschnig, Nature Cell Biology 8 (2006) 249–256.
date_created: 2018-12-11T12:00:50Z
date_published: 2006-03-01T00:00:00Z
date_updated: 2021-01-12T07:40:25Z
day: '01'
doi: 10.1038/ncb1369
extern: 1
intvolume: ' 8'
issue: '3'
month: '03'
page: 249 - 256
publication: Nature Cell Biology
publication_status: published
publisher: Nature Publishing Group
publist_id: '3694'
quality_controlled: 0
status: public
title: Intracellular trafficking and proteolysis of the Arabidopsis auxin-efflux facilitator
PIN2 are involved in root gravitropism
type: journal_article
volume: 8
year: '2006'
...